2019
DOI: 10.1017/cjn.2018.353
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Abstract: In recent decades, clinical trials in Alzheimer’s disease (AD) have failed at an unprecedented rate. The etiology of AD has since come under renewed scrutiny, both to elucidate the underlying pathologies and to identify novel therapeutic strategies. Here, diet has emerged as a potential causative/protective agent. A variety of nutrients, including lipids, minerals, vitamins, antioxidants and sugars as well as broader dietary patterns and microbiotal interactions have demonstrated associations with AD. Although… Show more

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Cited by 7 publications
(3 citation statements)
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References 188 publications
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“…However, we also recognise that the obese state is associated with the over-consumption of a combination of nutrients, contributing to intracellular stress and activation of an immune response [ 31 ]. As fats are rarely consumed in isolation as part of an obesogenic diet, we must also consider the influence of secondary metabolic perturbations resulting from sugar and cholesterol intake which are known to impact negatively on cognition [ 90 ], and act as primary risk factors for AD [ 91 ]. Replacing SFA for MUFA within the obesogenic diet may indeed convey some protection against cognitive decline.…”
Section: Discussionmentioning
confidence: 99%
“…However, we also recognise that the obese state is associated with the over-consumption of a combination of nutrients, contributing to intracellular stress and activation of an immune response [ 31 ]. As fats are rarely consumed in isolation as part of an obesogenic diet, we must also consider the influence of secondary metabolic perturbations resulting from sugar and cholesterol intake which are known to impact negatively on cognition [ 90 ], and act as primary risk factors for AD [ 91 ]. Replacing SFA for MUFA within the obesogenic diet may indeed convey some protection against cognitive decline.…”
Section: Discussionmentioning
confidence: 99%
“…However, a gradual decline in serum cholesterol is typically seen with dementias which shows the complexity of AD pathogenesis (Mielke et al, 2010;Presečki et al, 2011). Studies on fatty acids have yielded contradicting results, but generally saturated fats, trans-fats, and ω-6 fatty acids offer no benefit or may be detrimental in the context of AD while ω-3 fatty acids have demonstrated some potential benefits (Liyanage et al, 2019).…”
Section: Diet Alzheimer's Disease and Agingmentioning
confidence: 99%
“…The association between a diet rich in carbohydrates and AD progression is strong and there is speculation as to whether altered glucose metabolism may be causative in AD. Consistently high levels of dietary sugars is linked with insulin resistance, which has been proposed as a contributive factor for AD development (Liyanage et al, 2019). Interestingly, brains of AD patients have shown decreased levels of the glucose transporters GLUT1 and GLUT3, which allow glucose to cross the blood brain barrier and provide energy to the CNS (Szablewski, 2017).…”
Section: Diet Alzheimer's Disease and Agingmentioning
confidence: 99%