Alzheimer??s Disease in India

Arumugam, Shabari

doi:10.1097/00002093-198802030-00077

Cited by 3 publications

(4 citation statements)

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“…The accuracy of GRT from 4.2 K to 40 K was 20mK and from 40K to 100 K was 100 mK. The accuracy of PRT from 40 K to 300K was 100 mK [3].…”

Section: Data Collection and Pressure Calibration At Low Temperaturementioning

confidence: 89%

“…l shows the normalized susceptibility versus temperature for Pb and the inset shows the normalized resistance versus temperature for Nb -Zr sample from 4.2K to 300 K. The EPMA results show that the homogeneity was very good and the error was found to be less than 2%. The authors have reported the experimental details of high pressure low temperature resistivity measurements elsewhere [3]. …”

Section: Experimental Techniquesmentioning

confidence: 99%

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Pressure Effect on Tc in Nb-Zr Alloy.

Arumugam¹,

Sastry

Radhakrishnan

1998

THE REVIEW OF HIGH PRESSURE SCIENCE AND TECHNOLOGY

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“…The accuracy of GRT from 4.2 K to 40 K was 20mK and from 40K to 100 K was 100 mK. The accuracy of PRT from 40 K to 300K was 100 mK [3].…”

Section: Data Collection and Pressure Calibration At Low Temperaturementioning

confidence: 89%

Section: Experimental Techniquesmentioning

confidence: 99%

Pressure Effect on Tc in Nb-Zr Alloy.

Arumugam¹,

Sastry

Radhakrishnan

1998

THE REVIEW OF HIGH PRESSURE SCIENCE AND TECHNOLOGY

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“…It remains unresolved why this phase separation is easily observed in isolated PMs, but not in vivo. One possibility, supported by experimental [23][24][25] and theoretical [26][27][28] studies is that the cytoskeleton and transmembrane proteins prevent macroscopic phase separation by pinning/scaffolding membrane components. Another possibility is that macroscopic phase separation is manifested in nanodomains 29 , due to critical fluctuations 30,31 or other mechanisms 32,33 .…”

Section: Introductionmentioning

confidence: 99%

Myelin-Associated MAL and PLP Are Unusual among Multipass Transmembrane Proteins in Preferring Ordered Membrane Domains

et al. 2020

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Eukaryotic membranes can be partitioned into lipid-driven membrane microdomains called lipid rafts, which function to sort lipids and proteins in the plane of the membrane. As protein selectivity underlies all functions of lipid rafts, there has been significant interest in understanding the structural and molecular determinants of raft affinity. Such determinants have been described for lipids and single-spanning transmembrane proteins; however, how multi-pass transmembrane proteins (TMPs) partition between ordered and disordered phases has not been widely explored.Here we used cell-derived Giant Plasma Membrane Vesicles (GPMVs) to systematically measure multi-pass TMP partitioning to ordered membrane domains. Across a set of 24 structurally and functionally diverse multi-pass TMPs, the large majority (92%) had minimal raft affinity. The only exceptions were two myelin-associated four pass TMPs, Myelin and Lymphocyte protein (MAL) and ProteoLipid Protein (PLP). We characterized the potential mechanisms for their exceptional raft affinity and observed that PLP requires cholesterol and sphingolipids for optimal association with ordered membrane domains and that PLP and MAL appear to compete for cholesterolmediated raft affinity. These observations suggest broad conclusions about the composition of ordered membrane domains in cells and point to previously unrecognized drivers of raft affinity for multi-pass transmembrane proteins.

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“…Known as the 'prosperity vitamin', vitamin A has tradionally been a very scarce commodity in poor countries [14], Inhabitants of these countries derive most of their vitamin A from carotene precursors which do not carry the risk of vitamin A toxic ity [6]. Exposure to toxic levels of vitamin A does not occur, and Alzheimer's disease is accordingly rare or nonexistent [15][16][17], (5) The hypothesis might explain the im pression, if not the reality, that patients with early-onset Alzheimer's disease deteriorate faster than patients with late-onset disease. The latter group, more likely to be suffering from the usual aches and pains of old age, are more apt to be chronically medicated with aspirin or other anti-inflammtory agents, which may slow or halt the progression of the disease.…”

mentioning

confidence: 99%