Alzheimer’s disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes

Mustapić, Maja; Hadžija, Mirko; Pavlović, Mladen; Pavković, Pajica; Presečki, Paola; Mrazovac, Danijela; Mímica, Ninoslav; Korolija, Marina; Pivac, Nela; Mück‐Šeler, Dorotea

doi:10.1007/s11011-012-9310-1

Cited by 19 publications

(11 citation statements)

References 36 publications

(42 reference statements)

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“…The associations with RAVLT were the most consistent across the ethnic groups. Evidence is limited, but these findings support previous studies that have noted an increased percentage of APOE E2 allele carriers in people with diabetes and in African Americans (26,27). Given the increased frequency of the E2 haplotype in the population with diabetes, further efforts are needed to characterize the effects of the component haplogentoypes, E2E2 and E2E3, especially E2E2, which is relatively infrequent in the population (Supplementary Table 1).…”

Section: Discussionsupporting

confidence: 81%

APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND

et al. 2016

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OBJECTIVEDementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D.RESEARCH DESIGN AND METHODSEuropean Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)-DHS MIND (n = 517) were examined. The cognitive battery assessed executive function, memory, and global cognition, and brain MRI was performed.RESULTSIn European Americans and African Americans, the APOE E4 risk haplotype group was associated with poorer performance on the modified Mini-Mental Status Examination (P < 0.017), a measure of global cognition. In contrast to the literature, the APOE E2 haplotype group, which was overrepresented in these participants with T2D, was associated with poorer Rey Auditory Verbal Learning Test performance (P < 0.032). Nominal associations between APOE haplotype groups and MRI-determined cerebral structure were observed.CONCLUSIONSCompared with APOE E3 carriers, E2 and E4 carriers performed worse in the cognitive domains of memory and global cognition. Identification of genetic contributors remains critical to understanding new pathways to prevent and treat dementia in the setting of T2D.

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Section: Discussionsupporting

confidence: 81%

APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND

et al. 2016

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“…These discrepancies suggest that the genetic effect of TNF- α −308G>A is race-specific. While it imposes a significant risk on Han Chinese population, TNF- α −308G>A polymorphism might not be associated with T2DM risk in other racial populations such as Caucasians [7], [12], [36], [37], Japanese [38], [39] and Indians [40]. In addition to ethnic differences, a list of epidemiological and design factors (e.g., gender, age, life style, study design or limited sample size) may explain the contradictory results obtained in different studies as well.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of the Association between TNF-α −308G>A Polymorphism and Type 2 Diabetes Mellitus in Han Chinese Population

et al. 2013

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ObjectiveA meta-analysis was applied to evaluate the associations between tumor necrosis factor-α (TNF-α) −308G>A (rs1800629) polymorphism and type 2 diabetes mellitus (T2DM).MethodsHardy-Weinberg equilibrium (HWE) was employed to test genetic equilibrium among the genotypes of the selected literature. Power analysis was performed with the Power and Sample Size Calculation (PS) program. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with the Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed with Review Manager 5.1 and Stata 11.0.ResultsThere were 10 studies including 1425 T2DM patients and 1116 healthy control subjects involved in this meta-analysis. No significant publication bias was found in the studies. The pooled ORs (95% CIs) for TNF-α −308G>A of A vs. G allele and GA+AA vs. GG genotype were 1.63 (1.17–2.25) and 1.47 (1.17–1.85), respectively.ConclusionThis meta-analysis result suggested that TNF-α −308G>A polymorphism was strongly associated with T2DM risk, and A allele at this locus might be a susceptibility allele for the development of T2DM in Han Chinese population.

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“…Cytokines, such as IL‐1β, IL‐6 and TNF‐α, have been clearly involved in the inflammatory process located close to amyloid plaques, and are suggested to be cytotoxic when chronically produced . TNF‐α also has an important role in the pathophysiology of several disorders, such as obesity, DM and AD, as a pro‐inflammatory cytokine regulating inflammatory and immune responses . CRP is the key molecule of the acute phase of inflammation, and has been found in association with senile plaques and extracellular neurofibrillary tangles in AD .…”

Section: Discussionmentioning

confidence: 99%

“…Population‐based longitudinal studies have shown a higher risk of AD in patients with DM . Besides environmental factors, such as birthweight and childhood socioeconomic level and insulin resistance, ApoE protein and inflammation were suggested as common pathogenic components in these two progressive, disability‐inducing disorders with a high prevalence worldwide . Both insulin resistance and hyperglycemia are involved in disturbed synaptic plasticity, learning and memory functions .…”

Section: Introductionmentioning

confidence: 99%

Inflammatory hypothesis as a link between Alzheimer's disease and diabetes mellitus

Bozluolçay

Andican

Fırtına

et al. 2015

Geriatrics Gerontology Int

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Alzheimer’s disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes

Cited by 19 publications

References 36 publications

APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND

APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND

A Meta-Analysis of the Association between TNF-α −308G>A Polymorphism and Type 2 Diabetes Mellitus in Han Chinese Population

Inflammatory hypothesis as a link between Alzheimer's disease and diabetes mellitus

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