A Meta-Analysis of the Association between TNF-α −308G&gt;A Polymorphism and Type 2 Diabetes Mellitus in Han Chinese Population

Liu, Zhenghui; Ding, Yuanlin; Xiu, Liangchang; Pan, Haiyan; Liang, Yan; Zhong, Shouqiang; Liu, Weiwei; Rao, Shaoqi; Kong, Danli

doi:10.1371/journal.pone.0059421

Cited by 46 publications

(35 citation statements)

References 30 publications

(24 reference statements)

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“…Sensitivity analysis was performed by omitting each study in turn to assess the stability of the outcomes. 17 Funnel plot was used to perform the publication bias. In addition, a subgroup analysis by region was performed.…”

Section: Efficacy Of Surgical Treatment For Ldh S Ji Et Almentioning

confidence: 99%

Efficacy comparison between minimally invasive and conventional surgery for lumbar disc herniation in Chinese Han population: a meta-analysis

Shao

Wang

et al. 2014

Spinal Cord

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Study design: The pooled data were analyzed using RevMan 5.2 software. Objectives: The aim was to compare the efficacy of minimally invasive and conventional surgery for lumbar disc herniation (LDH) in Chinese Han population. Setting: China. Methods: An electronic search up to November 2013 was performed to retrieve all relevant articles. The overall standardized mean difference (SMD) for continuous outcomes and odds ratio (OR) for dichotomous variables as well as their 95% confidence intervals (CIs) were calculated to compare the efficacy of minimally invasive and conventional surgery. Results: A total of 23 studies involving 1913 patients treated by minimally invasive surgery and 2295 patients treated by conversational surgery were included in this meta-analysis. The overall estimate indicated that minimally invasive surgery could significantly decrease the hospitalization time (SMD ¼ À2.03, 95% CI, À2.49 to 1.56, Po0.0001), blood loss (SMD ¼ À2.65, 95% CI À3.33 to 1.97, Po0.0001), incision length (SMD ¼ À3.57, 95% CI, À4.39 to 2.75, Po0.0001), recurrence rate (odds ratio (OR) ¼ 0.22, 95 CI: 0.08-0.60, P ¼ 0.003) and complications (OR ¼ 0.47, 95% CI: 0.25-0.92, P ¼ 0.03) and increase the postoperative excellent rate (OR ¼ 1.82, 95% CI, 1.44-2.31, Po0.0001) compared with conventional surgery. In addition, the pooled data showed that there was no statistically significant difference in the operative time (SMD ¼ À0.58, 95% CI, À1.32 to 0.15, P ¼ 0.12) between LDH patients treated by minimally invasive and conventional surgery. Conclusion: In conclusion, minimally invasive surgery was a more safe and effective treatment for treating LDH in Chinese Han population when compared with conventional surgery.

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Section: Efficacy Of Surgical Treatment For Ldh S Ji Et Almentioning

confidence: 99%

Efficacy comparison between minimally invasive and conventional surgery for lumbar disc herniation in Chinese Han population: a meta-analysis

Shao

Wang

et al. 2014

Spinal Cord

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“…At the functional level, it has been reported that the A allele of rs1800629 increases the transcriptional rate of the gene [10,23,24]; additionally, this same polymorphism has been associated with different diseases, such as hepatic cirrhosis [25], gastritis, gastric cancer [26], Type 2 diabetes mellitus [27] and inflammatory-autoimmune diseases, such as ankylosing spondylitis [28], systemic lupus erythematosus [29] and rheumatoid arthritis [30]. With regard to respiratory diseases, Kumar et al found an association between the same polymorphism and bronchial asthma in an Indian population [31].…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in TNF are Associated with Susceptibility to Aspirin-exacerbated Respiratory Disease but not to Cytokine Levels: a Study in Mexican Mestizo Population

et al. 2017

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Aim:To evaluate the association of three single nucleotide polymorphisms in TNF and one in LTA in Mexican patients with aspirin-exacerbated respiratory disease (AERD) and the correlation of those single nucleotide polymorphisms with serum levels of TNF-α. Patients & methods: Case-control study including 133 patients with AERD, 135 patients with asthma (aspirin-tolerant asthmatics) and 182 healthy subjects. Results: GA genotype of rs1800629 in TNF was found to be associated with the risk of developing AERD (p < 0.05; odds ratio = 2.36) and by dominant model (p < 0.05; odds ratio = 2.51). Furthermore, there was a difference in the serum levels between the aspirin-tolerant asthmatics group and the other groups (p < 0.001). Conclusion: The GA genotype of rs1800629 is associated with genetic susceptibility to AERD, but it does not correlate to protein serum levels. Aspirin-exacerbated respiratory disease (AERD) is a clinical disease characterized by hypersensitivity to aspirin, asthma and chronic rhinosinusitis with nasal polyps. It affects 10% of the population with asthma; however, its prevalence increases to 21% when provocation tests are used [1]. AERD is a disease characterized by restructuring of the airway [2] and the presence of extensive hyperplastic eosinophilic sinusitis with the formation of nasal polyps [3]. The most important clinical characteristic is bronchoconstriction after the administration of aspirin (ASA) or other nonsteroidal anti-inflammatory drugs (NSAIDs) [2,4]. The physiopathology involves a block in the cyclooxygenase pathway that promotes a diversion of arachidonic acid metabolism toward the lipoxygenase pathway, inducing the synthesis of leukotrienes such as LTC4, LTD4 and LTE4 [5,6], proteins that induce inflammatory cell chemotaxis, and the release of cytokines such as TNF-α [7] and lymphotoxin. TNF-α is a critical molecule in the regulation of inflammation because it induces a cascade of other inflammatory cytokines, chemokines and growth factors [8]. The results of various in vivo and in vitro studies indicate that the increase in their production is involved in the severity of the inflammation, due to their participation in restructuring the airway and in the pro-oxidative response [9]. In relation to single nucleotide polymorphisms (SNPs), it has been reported that rs1800629 (G→A change in position -308) increases transcriptional activity [10,11], in addition to being associated with different pulmonary pathological diseases such as chronic obstructive pulmonary disease and asthma [9,12,13]. However, no SNPs have been reported in TNF or LTA that are associated with AERD.

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“…Patients with T2DM are at increased risk of other diseases including cardiovascular disease, kidney failure, blindness, neuropathy, and peripheral circulatory disease. T2DM thus has a significant impact on the quality of life of the patient, and increases the morbidity and mortality of other diseases (Liu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

Yang¹,

Yj²,

Liu³

2015

Genet. Mol. Res.

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ABSTRACT. Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated. Polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis and allelic specific PCR were employed for examining the TCF7L2 gene rs12255372 (G>T) and rs290487 (C>T), and rs7901695 (T>C) polymorphisms, respectively, in 109 healthy individuals and 111 subjects with T2DM who were of Chinese Hui descent and lived in the Ningxia Hui Autonomous Region of China. The results showed that the genotypic frequency of rs290487 and the allelic frequency distributions of the rs7901695 and rs290487 loci were not significantly different between patients and controls in this population. However, both the genotypic and the allelic frequencies at rs12255372 exhibited statistical 10065 TCF7L2 gene polymorphisms and T2DM©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 10064-10071 (2015) differences between the patients with T2DM and the unaffected cohort (P < 0.01). In addition, the frequency of the G allele at the rs12255372 locus in the patients was higher than that in healthy individuals (OR = 1.198, 95%CI = 1.097-1.307). These findings suggest that the TCF7L2 rs12255372 (G>T) polymorphism might be one of the most important genetic factors associated with T2DM susceptibility, and that individuals in the Chinese Hui population who carry a G allele at this locus might be at risk to develop T2DM.

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A Meta-Analysis of the Association between TNF-α −308G>A Polymorphism and Type 2 Diabetes Mellitus in Han Chinese Population

Cited by 46 publications

References 30 publications

Efficacy comparison between minimally invasive and conventional surgery for lumbar disc herniation in Chinese Han population: a meta-analysis

Efficacy comparison between minimally invasive and conventional surgery for lumbar disc herniation in Chinese Han population: a meta-analysis

Single Nucleotide Polymorphisms in TNF are Associated with Susceptibility to Aspirin-exacerbated Respiratory Disease but not to Cytokine Levels: a Study in Mexican Mestizo Population

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

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