Alzheimer Research Forum Live Discussion: Now you see them, now you don't: The amyloid channel hypothesis1

Fagan, Tom; Kagan, Bruce L.; Corbin, David R.; Hwang, Wonmuk; Glabe, C.G.; Nault, Larry; Lal, Ratnesh; Teplow, Dave; Albensi, Ben; Sokolov, Yuri

doi:10.3233/jad-2006-9213

Cited by 5 publications

(1 citation statement)

References 12 publications

(16 reference statements)

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“…Figure is reprinted with permission fromSperling et al, 2011 Aβ accumulation, indicating the onset of synaptic dysfunction (fluorodeoxyglucose PET)(Mosconi et al, 2008). Synaptic dysfunction gives way to tau phosphorylation, detected via changes in the CSF(Karikari et al, 2020), neurofibrillary tangle tau pathology (PET), hippocampal atrophy (structural MRI), and finally cognitive impairment(Bateman et al, 2012;T. Fagan et al, 2006;Gordon et al, 2016); (A. M.…”

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confidence: 99%

Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates

Shively

Lacreuse

Frye

et al. 2021

American J Primatol

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Aging across the Primate Order is poorly understood because ages of individuals are often unknown, there is a dearth of aged animals available for study, and because aging is best characterized by longitudinal studies which are difficult to carry out in long-lived species. The human population is aging rapidly, and advanced age is a primary risk factor for several chronic diseases and conditions that impact healthspan. As lifespan has increased, diseases and disorders of the central nervous system (CNS) have become more prevalent, and Alzheimer's disease and related dementias have become epidemic. Nonhuman primate (NHP) models are key to understanding the aging primate CNS. This Special Issue presents a review of current knowledge about NHP CNS aging across the Primate Order. Similarities and differences to human aging, and their implications for the validity of NHP models of aging are considered.Topics include aging-related brain structure and function, neuropathologies, cognitive performance, social behavior and social network characteristics, and physical, sensory, and motor function. Challenges to primate CNS aging research are discussed. Together, this collection of articles demonstrates the value of studying aging in a breadth of NHP models to advance our understanding of human and nonhuman primate aging and healthspan.

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