Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms

Babiloni, Claudio; Lizio, Roberta; Marzano, Nicola; Capotosto, Paolo; Soricelli, Andrea; Triggiani, Antonio Ivano; Cordone, Susanna; Gesualdo, Loreto; Percio, Claudio Del

doi:10.1016/j.ijpsycho.2015.02.008

Cited by 294 publications

(307 citation statements)

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“…Our results expand previous findings at channel level [22], confirm the relevance of the Theta band in neurodegenerative process and the functional differences between Alpha-1 and Alpha-2 rhythms. Previous findings in sporadic AD helped to speculate that posterior Delta/Theta increase of power density and Alpha power density decrease, during eyes-closed resting-state, reflect the neurodegenerative processes along the time course of the disease [23], that in the case of the Theta and Alpha rhythms could be due to failures to the thalamocortical circuitry [57]. Our results confirm the possibility of tracking the changes from asymptomatic to symptomatic in E280A mutation carriers in a posterior region of brain, as is the Precuneus.…”

Section: Discussionmentioning

confidence: 95%

“…On the contrary, the main changes in resting EEG spectral power density for sporadic AD are: widespread increases of delta and theta rhythms and decreases of posterior alpha and/or beta rhythms [23,24]. The lack of consistence between sporadic AD and asymptomatic E280A findings confirms the importance of spectral studies, particularly, in these frequency bands.…”

Section: Introductionmentioning

confidence: 82%

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Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

Villa-Ochoa

Alonso

Duque

et al. 2017

JAD

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Background: Presenilin-1 (PSEN1) mutations are the most common cause of familial early onset Alzheimer's Disease (AD). The PSEN1 E280A (E280A) mutation has an autosomal dominant inheritance and is involved in the production of amyloid-β. In Antioquia, Colombia, there is the largest family group of carriers with E280A mutation. The study of mutation carriers provides an unique opportunity to identify brain changes in stages previous to AD. Electroencephalography (EEG) is a low cost and minimally invasiveness technique that enables the following of brain changes in AD.Objective: To examine how previous reported differences in EEG for Theta and Alpha-2 rhythms in E280A subjects are related to specific regions in cortex and could be tracked across different ages. Methods: EEG signals were acquired during resting state from non-carriers and carriers, asymptomatic and symptomatic, subjects from E280A kindred from Antioquia, Colombia. Independent Component Analysis and inverse solution methods were used to locate brain regions related to differences in Theta and Alpha-2 bands.Results: Independent Component Analysis helps to identify two components, mainly related to the Precuneus, were the differences in Theta and Alpha-2 exist simultaneously at asymptomatic and symptomatic stage. When a ratio between Theta and Alpha-2 is used significant correlations exist with age and a composite cognitive scale. Conclusion:Theta and Alpha-2 rhythms are altered in E280A subjects. The alterations are possible to track at Precuneus regions using EEG, ICA and inverse solution methods.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 82%

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

Villa-Ochoa

Alonso

Duque

et al. 2017

JAD

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“…Candidate topographic neurophysiological (neurodynamic) biomarkers of AD can be derived from resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in subjects relaxed in quiet wakefulness (eyes closed, no sleep) with their mind freely wandering [310]. These rsEEG markers are non-invasive, cost-effective, available worldwide, and repeatable even in severe dementia.…”

Section: Contribution and Role Of Electroencephalography (Eeg)mentioning

confidence: 99%

“…They may probe the neurophysiological “reserve” in AD patients, as one of the dimensions of the brain reserve [311]. This neurophysiological “reserve” may reflect residual mechanisms for 1) “synchronization” of neural activity in a given cortical region and 2) the coupling of activity between nodes of a given brain neural networks as a sign of functional cortical “connectivity” [310, 312]. …”

Section: Contribution and Role Of Electroencephalography (Eeg)mentioning

confidence: 99%

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Hampel

Toschi

Babiloni

et al. 2018

JAD

Self Cite

126

113

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The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an “omics”-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND. The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems-based intermediate endophenotypes and candidate surrogate markers. Achieving these goals is key to the ultimate development of early and effective individualized treatment of ND, such as Alzheimer’s disease (AD). The Alzheimer Precision Medicine Initiative (APMI) and cohort program (APMI-CP), as well as the Paris based core of the Sorbonne University Clinical Research Group “Alzheimer Precision Medicine” (GRC-APM) were recently launched to facilitate the passageway from conventional clinical diagnostic and drug development towards breakthrough innovation based on the investigation of the comprehensive biological nature of aging individuals. The APMI movement is gaining momentum to systematically apply both systems neurophysiology and systems biology in exploratory translational neuroscience research on ND.

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“…Furthermore, EEG topography helped to reintroduce EEG by means of theta cordance as a diagnostic marker for depression [9] and as a personalized treatment-response biomarker for antidepressants [10,11]. EEG has also become important as a research and clinical tool in the diagnosis and treatment of developmental disorders such as attention deficit hyperactivity disorder [12] and for monitoring the functional (cognitive) decline in Alzheimer's disease (AD), also being both a preclinical and clinical functional readout of brain substrates such as loss of synaptic plasticity and impaired neuronal connectivity [13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Drinkenburg

Ruigt²,

Ahnaou

2015

Neuropsychobiology

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The contemporary value of animal pharmaco-electroencephalography (p-EEG)-based applications are strongly interlinked with progress in recording and neuroscience analysis methodology. While p-EEG in humans and animals has been shown to be closely related in terms of underlying neuronal substrates, both translational and back-translational approaches are being used to address extrapolation issues and optimize the translational validity of preclinical animal p-EEG paradigms and data. Present applications build further on animal p-EEG and pharmaco-sleep EEG findings, but also on stimulation protocols, more specifically pharmaco-event-related potentials. Pharmaceutical research into novel treatments for neurological and psychiatric diseases has employed an increasing number of pharmacological as well as transgenic models to assess the potential therapeutic involvement of different neurochemical systems and novel drug targets as well as underlying neuronal connectivity and synaptic function. Consequently, p-EEG studies, now also readily applied in modeled animals, continue to have an important role in drug discovery and development, with progressively more emphasis on its potential as a central readout for target engagement and as a (translational) functional marker of neuronal circuit processes underlying normal and pathological brain functioning. In a similar vein as was done for human p-EEG studies, the contribution of animal p-EEG studies can further benefit by adherence to guidelines for methodological standardization, which are presently under construction by the International Pharmaco-EEG Society (IPEG).

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Brain neural synchronization and functional coupling in Alzheimer's disease as revealed by resting state EEG rhythms

Cited by 294 publications

References 204 publications

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

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