Alveolar bone science: Structural characteristics and pathological changes

Ramalingam, Sundar; Sundar, Chalini; Jansen, John A.; Alghamdi, Hamdan S.

doi:10.1016/b978-0-08-102478-2.00001-5

Cited by 13 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trabecular bone is highly porous (40-95%) and more metabolically active than the cortical layer of bone. Overall, the density of bone increases from the inside out 10 . Some recent advancements in the tissue engineering eld have opened many new perspectives for research, but designing a novel scaffold that closely mimics the gradient structure of human alveolar bone, to achieve the seamless integration of multiple layers is still a major challenge to address 10,11 .…”

Section: Introductionmentioning

confidence: 96%

“…Overall, the density of bone increases from the inside out 10 . Some recent advancements in the tissue engineering eld have opened many new perspectives for research, but designing a novel scaffold that closely mimics the gradient structure of human alveolar bone, to achieve the seamless integration of multiple layers is still a major challenge to address 10,11 . Levingstone et al designed a multi-layered composite structure that failed to fully achieve the biomimetic function 12 .…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

WITHDRAWN: Biomimetic dual layered keratin/ hydroxyapatite scaffolds for alveolar bone regeneration

Feroz

Muhammad

Cathro

et al. 2022

Preprint

View full text Add to dashboard Cite

A new biomimetic dual layered keratin/hydroxyapatite scaffold was designed using the iterative freeze-drying technique. The physical, structural, and chemical properties of the keratin/hydroxyapatite (HA) scaffolds were studied using several analytical techniques. The developed multilayered, interconnected, porous keratin scaffold with different HA content in the outer and inner layer, mimics the inherent gradient structure of alveolar bone. The FT-IR analysis confirmed that the secondary structure of keratin was not destroyed with the successful incorporation of hydroxyapatite particles during the process of scaffold fabrication. X-ray diffraction analysis showed that the keratin and hydroxyapatite retained their crystalline structures in the prepared keratin/HA scaffolds. SEM studies showed an interconnected porous architecture of the prepared scaffolds with seamless integration between the upper and lower layers. EDX analysis showed that the inorganic phases of both the upper and lower layers of the keratin/HA scaffold mainly consist of calcium and phosphorous ions. EDX mapping confirmed the even distribution of calcium (Ca) and phosphorous (P) in both the upper and lower layers of the scaffold. The prepared scaffolds showed a gradual degradation during the 28-day incubation period in PBS. The incorporation of HA improved the mechanical properties of keratin/HA scaffolds. The keratin/HA scaffolds exhibited superior mechanical properties in terms of Young’s modulus and compressive strength in comparison to pure keratin scaffolds. The biocompatibility studies suggested that both keratin and keratin/HA scaffolds were cytocompatible, in terms of cell viability and proliferation. Furthermore, it showed that both the tested materials can be served as an ideal substrate for the differentiation of Saos-2 cells, leading to mineralization of the extracellular matrix. In summary, the development of a non-toxic green method was investigated for keratin extraction to fabricate keratin/HA scaffolds and our results showed great potential for the use of these scaffolds to regenerate alveolar bone due to their structural similarity and excellent in vitro biocompatibility.

show abstract

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

WITHDRAWN: Biomimetic dual layered keratin/ hydroxyapatite scaffolds for alveolar bone regeneration

Feroz

Muhammad

Cathro

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Although there is inadequate evidence to support routine extraction of primary maxillary canines to facilitate eruption of impacted permanent canines in children, early extraction of the deciduous canine has been advocated in many studies ( Alfaleh and Al Thobiani,2020 ). To maintain the alveolar bone for future implant placement ( Ramalingam et al, 2020 ) the canine maintains the width and depth of the alveolar bone for insertion of future dental implants ( Ramalingam et al, 2015 ). When the canine is then orthodonticaly moved distally to create space for the implants, the width and depth of the alveolar bone in the lateral incisor region is maintained( Scher,1990 ).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment modalities for missing lateral incisors– A systematic review

Alqahtani

2021

The Saudi Dental Journal

View full text Add to dashboard Cite

Background Effective management of Missing lateral incisor has remained a challenge for the clinicians. A multi-disciplinary approach involving orthodontist, restorative dental specialist, pediatric dental specialist, periodontist, oral surgeon and general dentist has proved ideal. Our aim is to review the ultimate esthetic success, and long term survival results between the orthodontic and restorative management of missing lateral incisor. Materials and methods Following the PRISMA guidelines, a systematic review of the published articles pertaining to the topic of interest was done. Searches were carried out in four different databases since February 2021 to April 2021. Results A total of 580 references were found from searches conducted in PubMed, Scopus, Cochrane and Web of Science, and 19 articles were selected and analyzed fully, after screening the title and abstract, 6 articles were included for the study. Conclusion An essential orthodontic space closure in combination with modern aesthetic prosthetic tooth replacement techniques has been reported to achieve greater success.

show abstract

“…After extraction, the tooth is considered a useless material and is eliminated, and for this reason, the use of this material has a low cost. The dental matrix contains HA and type 1, type 3 and type 5 collagen, and proteins are very similar to alveolar bone as they are both derived from the cells of the neural crest [ 55 , 96 , 97 , 98 ]. The hydroxyapatite present in the dental matrix has the same composition of HA as that present in bone, and for this reason, it is similar to the synthetic one [ 99 ].…”

Section: Bone Substitutes and Graftmentioning

confidence: 99%

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

et al. 2022

View full text Add to dashboard Cite

Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications. Methods: A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines. Results: After the initial screening, a total of 304 papers were considered eligible for the qualitative synthesis. The articles included were categorized according to the main topics: alloplastic bone substitutes, autologous teeth derived substitutes, xenografts, platelet-derived concentrates, laser therapy, microbiota and bone metabolism and mesenchymal cells construct. Conclusions: The effectiveness of the present investigation showed that the use of biocompatible and bio-resorbable bone substitutes are related to the high-predictability of the bone regeneration protocols, while the oral microbiota and systemic health of the patient produce a clinical advantage for the long-term success of the regeneration procedures and implant-supported restorations. The use of growth factors is able to reduce the co-morbidity of the regenerative procedure ameliorating the post-operative healing phase. The LLLT is an adjuvant protocol to improve the soft and hard tissues response for bone regeneration treatment protocols.

show abstract

Alveolar bone science: Structural characteristics and pathological changes

Cited by 13 publications

References 28 publications

WITHDRAWN: Biomimetic dual layered keratin/ hydroxyapatite scaffolds for alveolar bone regeneration

WITHDRAWN: Biomimetic dual layered keratin/ hydroxyapatite scaffolds for alveolar bone regeneration

Successful treatment modalities for missing lateral incisors– A systematic review

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

Contact Info

Product

Resources

About