Alveolar Bone Regeneration by Transplantation of Periodontal Ligament Stem Cells and Bone Marrow Stem Cells in a Canine Peri‐Implant Defect Model: A Pilot Study

Abstract

This study demonstrated the feasibility of using stem cell-mediated bone regeneration to treat peri-implant defects.

Rat dental pulp stem cells: isolation and phenotypic characterization method aiming bone tissue bioengineering

“…The differentiation of stem cells in osteoblasts may represent a breakthrough for tissue bioengineering. Studies have been demonstrating the DPSC potential to induce regeneration of critical-sized calvarial defects in mice (Moshaverinia et al 2014;Menicanin et al 2014); in canine and swine models, local implantation of DPSC, associated with β-TCP and HA/TCP scaffolds, successfully induced bone regeneration in critical-sized orofacial bone defects (Zheng et al 2009;Kim et al 2009). …”

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

“…However, in another group using a canine peri-implant defect model, BMSC showed superior alveolar bone regeneration [40] . Furthermore, PDLSC microencapsulation in RGD-coupled alginate enhanced MSC viability, proliferation and osteogenic differentiation both in vitro and in vivo [41] .…”

Dental Stem Cells: Sources and Potential Applications

“…PDL regeneration was detected on titanium implant surfaces in a rat molar implant model [64]. When PDLSCs loaded HA/TCP were implanted in a canine saddlelike peri-implant defect model, newly formed bone was found to fill in defects [65]. In addition, one human clinical study has demonstrated cell-coated implant placement in the mandible and PDL formation around the implant surface.…”