Alveolar bone healing accompanied by severe swelling in cleft children treated with bone morphogenetic protein-2 delivered by hydrogel

Neovius, Erik; Lemberger, Mathias; Skogh, Ac. Docherty; Hilborn, Jöns; Engstrand, Thomas

doi:10.1016/j.bjps.2012.08.015

Cited by 87 publications

(72 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the ability of rhBMP-2 to repair bone defects in orthopedic surgery has been known for some time, its use in craniofacial surgery (sinus elevation, alveolar cleft) has only been recently contemplated [30]. Although rhBMP-2 has shown promising results when compared to standard BG [2,4,5] it has also led to severe side effects, such as wound breakdown and acute respiratory failure, when used in the immature skeleton of young patients or close to airways [61,74,84].…”

Section: Discussionmentioning

confidence: 95%

Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – A preclinical study

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – A preclinical study

et al. 2015

View full text Add to dashboard Cite

“…Recently, a novel polymer hydrogel of sugarcane molasses appeared to be a good candidate to treat calvarial bone defects in rats, in association with Bone Morphogenetic Proteins (BMPs) [43]. In patients, hyaluronan-based hydrogels associated with BMP-2 greatly enhanced the healing of critical-size cranial defects [44] or alveolar cleft defects [45], and alginate-agarose hydrogels combined with autologous chondrocytes significantly improved clinical outcome in patients suffering from chondral or osteochondral defects over a 2-year follow-up [46]. …”

Section: Discussionmentioning

confidence: 99%

Calcium-phosphate ceramics and polysaccharide-based hydrogel scaffolds combined with mesenchymal stem cell differently support bone repair in rats

Frasca¹,

Norol

Visage

et al. 2017

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Research in bone tissue engineering is focused on the development of alternatives to autologous bone grafts for bone reconstruction. Although multiple stem cell-based products and biomaterials are currently being investigated, comparative studies are rarely achieved to evaluate the most appropriate approach in this context. Here, we aimed to compare different clinically relevant bone tissue engineering methods and evaluated the kinetic repair and the bone healing efficiency supported by mesenchymal stem cells and two different biomaterials, a new hydrogel scaffold and a commercial hydroxyapatite/tricalcium phosphate ceramic, alone or in combination.Syngeneic mesenchymal stem cells (5 × 105) and macroporous biphasic calcium phosphate ceramic granules (Calciresorb C35®, Ceraver) or porous pullulan/dextran-based hydrogel scaffold were implanted alone or combined in a drilled-hole bone defect in rats. Using quantitative microtomography measurements and qualitative histological examinations, their osteogenic properties were evaluated 7, 30, and 90 days after implantation. Three months after surgery, only minimal repair was evidenced in control rats while newly mineralized bone was massively observed in animals treated with either hydrogels (bone volume/tissue volume = 20%) or ceramics (bone volume/tissue volume = 26%). Repair mechanism and resorption kinetics were strikingly different: rapidly-resorbed hydrogels induced a dense bone mineralization from the edges of the defect while ceramics triggered newly woven bone formation in close contact with the ceramic surface that remained unresorbed. Delivery of mesenchymal stem cells in combination with these biomaterials enhanced both bone healing (>20%) and neovascularization after 1 month, mainly in hydrogel.Osteogenic and angiogenic properties combined with rapid resorption make hydrogels a promising alternative to ceramics for bone repair by cell therapy.

show abstract

“…1 HA is extensively used in the biomedical field, for example, in ophthalmic surgery, 2,3 arthritic treatment, 4,5 and dermal fillers, 6 as well as tissue engineering. 6,7 However, many applications show that hyaluronan is unable to give sufficient efficacy if used without chemical crosslinking owing to its incapability of forming physical gels over a wide pH range 8 Depending on pH, HA carries a negative charge on every second monomer. The conformation of HA in solution is stabilized by intramolecular H bonds, 9 resulting in a relatively stiff polymer conformation.…”

Section: Introductionmentioning

confidence: 99%

Preparation and physical properties of hyaluronic acid‐based cryogels

Ström

Larsson

Okay

2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

Macroporous hydrogels based on hyaluronan (HA), a natural polysaccharide occurring in extracellular matrix, have attracted interest over many years owing to their numerous applications in the biomedical area. However, HA hydrogels produced so far suffer from low mechanical strength and slow rate of response against external stimuli, which limit their applications. Here, we prepared macroporous HA cryogels of high mechanical stability and fast responsivity from aqueous HA solutions at subzero temperatures using ethylene glycol diglycidyl ether as a crosslinking agent. HA cryogels are squeezable and no crack development was exhibited when compressed up to 80% strain. Depending on the synthesis parameters, the cryogels exhibit an elastic modulus between 0.2 and 2 kPa, and show fast swelling/deswelling behavior. The microstructure of the cryogels consists of large, interconnected pores on the order of 100 mm separated by thick pore walls, as observed by scanning electron microscopy and confocal scanning laser microscopy.

show abstract

Alveolar bone healing accompanied by severe swelling in cleft children treated with bone morphogenetic protein-2 delivered by hydrogel

Cited by 87 publications

References 91 publications

Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – A preclinical study

Direct comparison of current cell-based and cell-free approaches towards the repair of craniofacial bone defects – A preclinical study

Calcium-phosphate ceramics and polysaccharide-based hydrogel scaffolds combined with mesenchymal stem cell differently support bone repair in rats

Preparation and physical properties of hyaluronic acid‐based cryogels

Contact Info

Product

Resources

About