Alveolar Bone Grafting in Cleft Patients: from Bone Defect to Dental Implants

Vuletić, Marko; Knežević, Predrag; Jokić, Dražen; Rebić, Jerko; Žabarović, Domagoj; Macan, Darko

doi:10.15644/asc48/4/2

Cited by 15 publications

(10 citation statements)

References 35 publications

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“…Cleft lip, alveolus, and palate are often associated with dental anomalies and malocclusions [45][46][47]. Many dental disturbances can be created by the cleft area including impacted teeth, supernumerary teeth, microdontia, and hypodontia [46,47]. The maxillary lateral incisor is the most affected tooth by the cleft defect [46].…”

Section: Cleftsmentioning

confidence: 99%

Unusual Indications of Teeth Transplantation: A Literature Review

Al‐Khanati¹,

Albassal²,

Beit³

2022

Cureus

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Dental implants are one of the best valid tooth replacement options, though these are not always appropriate in growing young patients. Tooth autotransplantation can be indicated then. However, this is not the only scenario where dental transplantation can be indicated. This comprehensive literature review discusses a wide range of unusual indications of dental transplantation as reported throughout the medical literature. Surprisingly, these indications include management of some developmental dental anomalies, hypodontia, oroantral communications, alveolar clefts, deficient alveolar ridges, ectopic teeth, and maxillofacial injuries. Limited high-quality evidence in this field regarding most of these unusual indications warrants further research of high-quality design.

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Section: Cleftsmentioning

confidence: 99%

Unusual Indications of Teeth Transplantation: A Literature Review

Al‐Khanati¹,

Albassal²,

Beit³

2022

Cureus

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“…The definitive timing of alveolar cleft repair is controversial as it can be applied primarily during infancy, or secondarily later on [9] . However, the alveolar cleft is usually treated between 7 and 11 years of age and is often connected to the development of the maxillary canine root [10] . Bone grafting materials are variable including autografts, isografts, allografts, alloplastic grafts, xenografts along with bone graft substitute.…”

Section: Introductionmentioning

confidence: 99%

Early Versus Late Alveolar Cleft Repair Using Cancellous Iliac Bone Grafts in A developing country

Makharita

Sayouh

Amin

2021

International Journal of Medical Arts

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Background: Orofacial clefts are common congenital malformations, with alveolar cleft as the most common [75%] of all anomalies.Many treatment modalities are available. However, our clinical experience with bone graft modality is not well addressed. The aim of the work:To evaluate the effectiveness of early [2 to 12 years; before complete eruption of the cleft canine] versus late [> 12 years; after complete eruption of the cleft canine] cancellous anterior iliac bone grafting for alveolar cleft reconstruction.Patients and Methods: Twenty-three patients with alveolar clefts who were admitted for alveolar cleft reconstruction surgery were included. They were categorized into early and late secondary grafting groups. All patients inquired about their history. Submitted to full clinical examination, laboratory and radiological examinations. The imaging studies include two-dimensional orthopantomogram for all patients, while 3-D fascial computed tomography and cone-beam computed tomography were done for selected patients. Both intraoperative and postoperative data were collected, any complications were registered and patients followed up regularly up to 6 months.Results: Both groups were comparable as regarding patient characteristics except younger age in early group, and there was a statistically significant difference between early and late groups regarding cleft side and cleft permanent canine full eruption. Males represented 69.9%. The cleft was on the left side in 56.4%. Seven patients [30.4%] had maternal risk factor [five in early and two in late group]. Blood loss was less than 80 ml in all patients in both groups. All oronasal fistulas were sealed off successfully in all patients [100%] and all had normal healthy gingival contour with vital teeth adjacent to the cleft. All showed evidence of good bone filling in the alveolar defect after 6 months postoperatively. Only one patient developed hypertrophic scars at each group. Conclusion:Alveolar cleft reconstruction is preferred to perform autologous cancellous bone grafting harvested from the iliac crest bone to repair the cleft with excellent outcome on short-term follow-up.

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“…The loss of bone tissue attributed to cancer, trauma, or infections significantly disrupts the patients' quality of life 1,2) . The functionalization of natural polymers is considered a seminal way to provide ideal materials applicable for bone diseases in advanced bone regenerative medicine 3) .…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria

Honda

Huang

Zhao

et al. 2020

J. Hard Tissue Biology.

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The potential of plant-derived polyphenols in bone tissue engineering has not been fully realized owing to difficulties in maintaining their stability in affected parts. Catechins, such as epigallocatechin gallate (EGCG), are not fully utilized in bone regenerative medicine. Here, we demonstrated that chemical and non-chemical modifications of gelatin with EGCG resulted in distinct bone-forming abilities in critical-sized bone defects (9 mm) in rat calvaria. We prepared two EG-CG-containing gelatin sponges: vacuum-heated gelatin sponges modified chemically with EGCG (AC-vhEGCG-GS) and vacuum-heated gelatin sponges with EGCG (no chemical modification; NC-vhEGCG-GS). Both sponges were characterized using scanning electron microscopy and degradability and EGCG-retention tests. The bone-forming ability of the sponges were estimated using micro-computed tomography and hematoxylin-eosin staining; the quality of newly formed bone (collagen maturation) was determined using picrosirius red staining and polarized microscopy. Both sponges had a spongy and soft texture with macropores ranging 50-150 µm with negligible differences in degradability. The NC-vhEG-CG-GSs released all their EGCG content within 1 h, whereas AC-vhEGCG-GSs retained 75% of the EGCG for up to 24 h. In addition, AC-vhEGCG-GSs resulted in a significantly greater bone formation than NC-vhEGCG-GSs 4 w after implantation, with negligible differences in collagen maturation. These results suggest that the chemical modification of gelatin with EGCG might be a promising strategy to fully utilize the pharmacological effects of EGCG for natural polymer-based sponges. Moreover, the release rate of EGCG from gelatin is possibly a screening parameter affecting the function of EGCG in vivo.

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Alveolar Bone Grafting in Cleft Patients: from Bone Defect to Dental Implants

Abstract: Adresa za dopisivanje doc. dr. sc. Predrag Knežević Sveučilište u Zagrebu Stomatološki fakultet Klinika za kirurgiju lica, čeljusti i usta Klinička bolnica Dubrava,

Cited by 15 publications

References 35 publications

Unusual Indications of Teeth Transplantation: A Literature Review

Unusual Indications of Teeth Transplantation: A Literature Review

Early Versus Late Alveolar Cleft Repair Using Cancellous Iliac Bone Grafts in A developing country

Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria

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