Alveolar-Arterial O2 and CO2 Differences in the Dog Breathing Air and Low O2 Mixtures

Suskind, Mitzi

doi:10.1152/ajplegacy.1954.177.2.227

Cited by 10 publications

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“…The alveolar-arterial O2 and CO2 pressure differences in our dogs during spontaneous breathing at high ventilation were not much different from values reported at normal ventilation [Haab el al., 1964;Suskind, 1954], Transition from spontaneous breathing to pump ventila tion has been shown not to increase distribution inequalities per se [Aoyagi and Piiper, 1965]. This is not in agreement with the present experiments, where important rises in the alveolar-arterial pressure differences for O* and CO2 during body box ventilation was found, and should be attributed to the simultaneously decreased lung volume.…”

Section: Functional Inhomogeneitiescontrasting

confidence: 96%

Comparison of Rebreathing and Steady-State Pulmonary Do2 in Dogs Ventilated by Body Respirator

Adaro¹,

Teichmann²,

Lüdtke-Handjery³

et al. 1974

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Alveolar gas exchange was studied com-paratively in anaesthetised dogs during spontaneous breathing and during artificial ventilation produced by a body respirator. The pulmonary O₂ diffusing capac- ity, D O₂, in particular, was measured, employing two different methods: the conventional steady-state method, using ideal alveolar P O₂ (D O₂SS) and a rebreathing method (Do_2RB). A considerable decrease (by a factor of 3) in both D o_2SS and D_O2RB was observed on transition from spontaneous breathing to artificial ventilation. Distributional inhomogeneities were found to be considerably increased during artificial ventilation as indicated by increased values of both alveolar dead space ventilation and venous admixture. The increased inhomogeneity was probably due to considerably decreased end-expiratory lung volume during artificial ventilation at mean intrapulmonary pressure zero. The observed reduction in D_O2 should, at least in part, be attributed to the enhanced distributional inhomogeneity during artificial ventilation at low lung volume. Apparently, D_O2SS and D_O2RB are affected about equally by distributional inequalities in the lung