Aluminum‐mediated metabolic changes in rat serum and urine: A proton nuclear magnetic resonance study

Tripathi, Sandeep; Somashekar, Bagganahalli S.; Mahdi, Abbas Ali; Gupta, Ashish; Mahdi, Farzana; Hasan, Mahdi; Roy, Raja; Khetrapal, C. L.

doi:10.1002/jbt.20219

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…The results also agree with Kielczykowska M, et al who reported that lithium carbonate and L-ascorbic acid in co administration, in treated rats, in the form of water solution by stomach tube for 6 weeks caused slight increase in serum creatinine this agreed with group C in this study but different than groups (D and E) [22]. Tripathi S, et al explained this to be attributed to the fact that, the increment of creatinine in blood could be related to the reabsorption of creatinine in the glomerular filtrate, lower rates of glomerular filtration, which might be expected due to perturbation of the renin-angiotensin system [25]. This could cause reduction of renal cortical blood flow; which was evident in the present study by histopathological findings of the kidneyes.…”

Section: Discussionsupporting

confidence: 82%

“…This suggested that, the increase of uric acid in blood could be related to the lower rates of glomerular filtration, which might be expected due to perturbation of the renin-angiotensin system. As it could cause reduction of renal cortical blood flow as stated by Tripathi S, et al [25]. This was evident in the present study by the histopathological findings of the kidneys.…”

Section: Discussionsupporting

confidence: 81%

“…The increase of serum creatinine, can be attributed to the fact that, the increment of creatinine in blood could be related to the reabsorption of creatinine in the glomerular filtrate, lower rates of glomerular filtration, which might be expected due to perturbation of the renin-angiotensin system. This could cause reduction of renal cortical blood flow [25]. Which was evident in the present study by histopathological findings of the renal damage.…”

Section: Discussionsupporting

confidence: 72%

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Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats

Modawe¹

2018

IJBP

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Backgrounds: Lithium carbonate is drug has been used for prolonged treatment of psychiatric disorders. But was known to be accompanied by side effects and highly toxicity especially to renal tissue.Objectives: this study aimed to investigate the influence of lithium carbonate and ascorbic acid on the kidney tissue in Wistar albino rats.Methodology: Ninety rats were used in two experiments. The experiment was performed in three months and blood samples were collected monthly, then specimen of the kidney, was used for histopathological examination. In experiment 1, forty rats were used and divided to four groups, three groups were subjected to different oral doses of drug (9, 17 and 34 mg/kg/BW) daily and the fourth was kept as control group. In experiment 2, fifty rats were used and divided to five groups, ascorbic acid, (7mg/kg BW) as antioxidant was added to the different doses of drug during the experimental period.Results: Urea and creatinine showed significantly (P≤0.005) higher levels in the groups used different doses of the lithium therapy compared to the control group. Only the uric acid showed significantly (P≤0.003) lower level compared to the control group. Tubular necrosis, congestion and infiltration of inflammatory cells were the common pathological lesions observed in the kidney and congestion of capillaries was the common pathological lesion at different doses of lithium carbonate. The serum levels of urea and uric acid were significantly (p≤0.004) increased in all groups of the treated rats compared to the control group. The serum creatinine was significantly (P≤0.000) higher in rats treated with 9mg/kg BW, and ascorbic acid but other groups treated with higher doses and ascorbic acid showed significantly (p≤0.000) lower levels compared to the control group. For histopatholgical changes, when drug was accompanied by Lascorbic acid, the infiltration of inflammatory cells was less in kidney compared to the groups treated with lithium carbonate alone.Modawe GA and ElBagir NM. Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats. Int J Biochem Physiol 2018, 3(3): 000129.Copyright© Modawe GA and ElBagir NM.2 Conclusions: The use of L-ascorbic acid alone also reduced infiltration of inflammatory cells. The study recommended that patients on drug should be periodically evaluated for renal dysfunction and also advised to be supplied with ascorbic acid, to reduce the toxicity of lithium therapy. Future studies should investigate the effect of different doses of the ascorbic acid on responses to lithium therapy. Also the effects of other antioxidants on drug responses should be tested.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 72%

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Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats

Modawe¹

2018

IJBP

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“…The spontaneous motor activity (SMA), righting reflex, catalepsy, muscle coordination, active avoidance and passive avoidance were in accordance with a previously described method [19].…”

Section: Behavioral Studiesmentioning

confidence: 99%

Correlation of Age-Related Metabonomic Changes in 1H NMR Serum and Urine Profiles of Rats with Cognitive Function

Mahdi¹,

Annarao²,

Tripathi³

et al. 2008

TOMRJ

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Age related metabonomic changes in young and aged male albino rats have been investigated using Proton Nuclear Magnetic Resonance ( 1 H NMR) spectroscopy. The studies were performed using 'in vivo' behavioral and metabonomic assessment in serum and urine of the rats. Significant changes (p<0.05) were obtained in the concentration of creatinine, allantoin and hippurate in urine. Also significant (p<0.05) alterations were also discernible in acetate, pyruvate, lactate, creatine and glucose in serum. Attempts have been made to correlate these changes with the cognitive impairment and perturbed energy metabolism in aged rats. The metabonomic evaluation of age related changes in serum and urine showed altered concentrations of many Krebs cycle intermediates in old rats. Likewise it was associated with diminished mitochondrial functioning. On the basis of our results it is suggested that the observed changes may be an early clinical indication of cognitive decline related to dementia.

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“…Proton NMR spectroscopy provides enriched information about identification of metabolites in body fluids such as serum and urine [1]. Metabonomics is a powerful and emerging technology that characterizes the complex time-dependent metabolic profiles within biofluids and tissues.…”

Section: Introductionmentioning

confidence: 99%

Metabolite characterization in serum samples from normal healthy human subjects by 1H and 13C NMR spectroscopy

Misra¹,

Bajpai²

2009

Bull. Chem. Soc. Eth.

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ABSTRACT. ABSTRACT. ABSTRACT. ABSTRACT. One and two dimensional NMR spectroscopy has been employed to characterize the various metabolites of serum control healthy samples. Two dimensional heteronuclear experiment has been included to take advantage of larger chemical shift spread of 13 C resonances allowing a more detailed identification of metabolites not possible in one dimensional spectra. This methodology has successfully allowed the assignment of ninety four resonances of various metabolites. The importance of the work lies in the fact that characteristic fingerprints of various metabolites of serum samples of normal healthy control have been obtained which can identify and distinguish metabolic differences from other diseased specimens or non-diseased/healthy serum samples. This study will help enhance the literature of metabolite identification in serum samples. KEY WORDS: KEY WORDS: KEY WORDS:

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Aluminum‐mediated metabolic changes in rat serum and urine: A proton nuclear magnetic resonance study

Cited by 17 publications

References 40 publications

Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats

Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats

Correlation of Age-Related Metabonomic Changes in 1H NMR Serum and Urine Profiles of Rats with Cognitive Function

Metabolite characterization in serum samples from normal healthy human subjects by 1H and 13C NMR spectroscopy

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