Aluminum accumulation in serum liver and spleen of fe-depleted and fe-adequate rats

Ts, Brown; Schwartz, Ruth

doi:10.1007/bf02783892

Cited by 17 publications

(4 citation statements)

References 21 publications

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“…Based on the similar chemistry of A1 and Fe(III), it was postulated that A1 might share with Fe some mechanisms of intestinal absorption, and that this might be affected by the individual's efficiency of the Fe-absorptive mechanism (Cannata et al 1993;Powell & Thompson 1993). Although it was hypothesized that A1 absorption and accumulation in the body would be inversely related to Fe status (Brown & Schwartz 1992), recent investigations have suggested that the interaction between Al and Fe would be less particularly significant than predicted by others (Greger et al 1995).…”

Section: Discussionmentioning

confidence: 99%

Effects of Aluminium on the Mineral Metabolism of Rats in Relation to Age

Sánchez

Gómez

Llobet

et al. 1997

Pharmacology & Toxicology

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The present study was conducted to assess in rats the effects of chronic aluminium (Al) exposure on calcium (Ca), magnesium (Mg), manganese (Mn), copper (Cu), zinc (Zn) and iron (Fe) accumulation and urinary excretion in relation to the age of the animals. Male young (21 day old), adult (8 months), and old (16 months) rats were orally exposed to 0, 50, or 100 mg AVkg/day for a period of 6.5 months. Urinary levels of essential elements were determined after 3 and 6.5 months of exposure, whereas tissue Ca, Mg, Mn, Cu, Zn and Fe concentrations were examined after 6.5 months of A1 administration. A number of age-related changes in tissue accumulation and urinary excretion of essential elements following chronic exposure to A1 were found. Concentrations of essential elements in most tissues of young Al-exposed rats were generally lower than those of adult and old rats. The highest levels of essential elements were found in old animals. Liver, testes and spleen were the tissues that showed the most remarkable increases in relation to the levels found in those tissues of young rats. Adult rats showed a pattern comparable to that of old animals for mineral metabolism in brain, whereas in bone and testes the pattern of accumulation was closer to that of young rats. While the urinary levels of Ca were generally reduced in the Al-exposed groups, no Al-associated changes were noted for Mg, Mn, Cu and Zn. In turn, after 6.5 months of A1 administration Fe excretion was increased in Al-treated adult and old rats. The results of this study suggest that early stages of life cycle should be of special concern for Al-induced changes in the metabolism of essential elements.

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Section: Discussionmentioning

confidence: 99%

Effects of Aluminium on the Mineral Metabolism of Rats in Relation to Age

Sánchez

Gómez

Llobet

et al. 1997

Pharmacology & Toxicology

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“…Aluminum decreased in cataractous lenses in the present study. Decreased aluminum and increased iron in the lens remind us of the existing competitive interrelationships between these elements for absorption, transport and cellular distribution described previously [19].…”

Section: Discussionmentioning

confidence: 99%

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Çekıç

Bardak²,

Totan³

et al. 1999

Ophthalmic Res

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Atomic absorption spectrophotometry was used to detect lenticular nickel, chromium, manganese, iron and aluminum levels in 37 senile cataractous and 9 normal human lenses. The nuclear parts of the lenses were used for the study in both groups. It was found that the concentrations of nickel and iron were significantly higher, and those of chromium, manganese and aluminum were significantly lower in human cataractous lenses than those in normal human lenses. None of the elements showed a significant difference according to sex in both groups. As remarkable differences in chromium, manganese, iron, aluminum and nickel levels exist in cataractous lenses, all the five elements may play some roles in cataractogenesis.

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“…Brown & Schwartz (1992) assumed that aluminium binds with ligands at the same sites as Fe 3π , and they observed significant Al increase in the liver and spleen of rats fed iron-deficient diet. Golub et al (1996) did not to observe the effect of dietary aluminium excess (doses about 100 mg) on Fe level in the brain and liver, nor did Oteiza et al (1993) observe any change in Fe concentration in the cerebrospinal fluid, brain, liver and bones, in mice given about 300 mg Al.…”

Section: Discussionmentioning

confidence: 99%

Effects of Various Aluminium Compounds Given Orally to Mice on Al Tissue Distribution and Tissue Concentrations of Essential Elements

Długaszek

Fiejka

Graczyk

et al. 2000

Pharmacology & Toxicology

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To evaluate the risk of gastrointestinal long-term aluminium (Al) exposure, aluminium distribution and the levels of the following essential elements: Ca, Mg, Zn, Cu, and Fe in tissue were studied. Aluminium was administered in drinking water as aluminium chloride, dihydroxyaluminium sodium carbonate or aluminium hydroxide. Mice (strain Pzh:SFIS) were exposed to a total dose of 700 mg Al in long-term treatment (for each Al compound nΩ15). Concentrations of Al, Ca, Mg, Zn, Cu, and Fe in stomach, kidneys, bone and liver were analyzed by atomic absorption spectrometry. After AlCl 3 treatment, aluminium was found to accumulate in all tested tissues. A significant decrease in Fe concentration in liver and Zn in kidneys was observed in comparison to concentrations of these elements in the control group. In the Al(OH) 3 -treated group, accumulation of aluminium was observed in bone only and decline of Fe concentration in stomach and Cu in liver and kidney. In the NaAl(OH) 2 CO 3 -treated group the increase in Al concentration was significant in bone; there was no change in concentration of essential elements in the examined tissues. The observed aluminium accumulation was not accompanied by changes in Ca and Mg concentration except for bone. This study showed that oral administration as a route of Al exposure can result in diverging accumulation of aluminium in tissues, the concentration depending on the chemical form.

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Aluminum accumulation in serum liver and spleen of fe-depleted and fe-adequate rats

Cited by 17 publications

References 21 publications

Effects of Aluminium on the Mineral Metabolism of Rats in Relation to Age

Effects of Aluminium on the Mineral Metabolism of Rats in Relation to Age

Nickel, Chromium, Manganese, Iron and Aluminum Levels in Human Cataractous and Normal Lenses

Effects of Various Aluminium Compounds Given Orally to Mice on Al Tissue Distribution and Tissue Concentrations of Essential Elements

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