Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin

Afolabi, Olusegun K.; Wusu, Adedoja Dorcas; Ugbaja, Regina Ngozi; Fatoki, John Olabode

doi:10.1177/2397847318812794

Cited by 27 publications

(34 citation statements)

References 74 publications

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“…It is suggested that ROS has a higher affinity for the thiol groups in the biomolecules, leading to the depletion of thiols intracellularly; consequently resulting in reduced GSH concentrations (Irvine, ). Mohamed and El‐Moneim () and Afolabi, Wusu, Ugbaja, & Fatoki () showed in their study, Al administration reduced the activity level of antioxidant enzymes. In our study, AlCl 3 administration led to an increase in MDA levels, decreased levels of GSH and diminished CAT activity.…”

Section: Discussionmentioning

confidence: 91%

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

et al. 2019

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Aluminium is a ubiquitous element that occurs naturally in the soil making human exposure to it is unavoidable. Tyrosol is present in olive oil and is known to have antioxidant effects. Therefore, the present study explores the toxic effects of aluminium chloride (AlCl3) and evaluates the possible protection by tyrosol in male rats. Testicular injury was induced by the administration of AlCl3 (34 mg kg−1 day−1). Rats were treated with either tyrosol (20 mg kg−1 day−1) or AlCl3 (34 mg kg−1 day−1). The experiment lasted for 10 weeks. Biochemical, histopathological and protein expression profiles were determined to decipher the role of tyrosol in protecting the cellular damage. Further, histomorphometric analyses of testes showed deranged architecture along with other noted abnormalities. AlCl3 group rats' testes showed decreased GSH levels, CAT activities, Nrf‐2, HO‐1, bcl‐2 expressions and sperm motility whereas increased caspase‐3 expressions, MDA levels, abnormal and dead/live sperm ratio. However, tyrosol treatment attenuated these changes. The present results demonstrate the beneficial role of tyrosol treatment in AlCl3 induced testicular toxicity alterations of rat.

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Section: Discussionmentioning

confidence: 91%

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

et al. 2019

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“…The unsaturated fatty acids undergo oxidation which is detrimental to sperm cell, germ cell membrane, eventually inducing cell death (Proudfoot, 2007). Excess ROS can also damage biomolecules (DNA, lipids and proteins) thus, altering the morphology and functions of the testes (Uzunhisarcikli et al, 2007;Afolabi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Toxicological Effects of Ethanolic Stem Bark Extract of Xylopia Aethiopica on Testicular Oxidative Stress Markers and Histology of Male Rats

Adikwu

Ehigiator²

2020

BIOMEDNATPROCH

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Impairment in testicular function can occur through perturbations in testicular oxidative stress markers and histology. Xylopia aethiopica (XE) is used to enhance fertility in males, but with information gap on its effect on testicular oxidative stress markers and histology. The present study assessed the effects of ethanolic stem bark extract of Xylopia aethiopica (EEXA) on testicular oxidative stress markers and histology of male albino rats. Sixty adult male albino rats (200g-250g) were randomly grouped into 4 (A-D) of 15 rats per group. The rats in the control group A (A1-A3) were administered per oral (p.o) with water (0.2 mL/day) for 15, 30 and 60 days respectively. The rats in groups B (B1-B3), C(C1-C3) and D (D1-D3) were administered p.o with EEXA (200, 400 and 800 mg/kg/day) for 15, 30 and 60 days respectively. The rats were anesthetized at the termination of EEXA administration and were dissected and testes removed. The testes were weighed and evaluated for oxidative stress markers and histology. Testicular weights were decreased in a dose and-time dependent fashion in EEXA-treated rats. Significant decreases in testicular superoxide dismutase, glutathione, catalase, and glutathione peroxidase levels with significant increases in malondialdehyde levels in a dose and time-dependent fashion were observed in rats administered with EEXA. Testicular histology showed cellular necrosis, degeneration and loss of interstitial tissues in rats administered with EEXA. This study observed that EEXA perturbed testicular oxidative markers and histology. Its use may impair testicular function.

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“…The observed decrease in both SOD and CAT activities indicated a breakdown of enzymatic system due to Zn-P-induced oxidative stress. A reduction in SOD activity usually leads to an increased level of superoxide anion, which can subsequently inactivate CAT activity [31]. Conversely the inability of CAT to prevent H 2 O 2 accumulation in the cell could lead to inactivation of SOD.…”

Section: Discussionmentioning

confidence: 99%

Zinc Phosphide-Induced Hepato-Nephrotoxicity in Wistar Rats: The Ameliorative Role of Curcumin from Curcuma longa Rhizome

Akinwunmi

Ofeniforo

Fasunle

2021

EJMP

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Globally used pesticides contains zinc phosphide (ZnP) which are toxic. This present study was carried out to investigate the potency of bioactive curcumin in ameliorating the toxicity of zinc phosphide on biochemical enzymes present in kidney and liver of Wistar rats. A total of 30 (120–150 g) male adult Wistar rats were used. Experimental animals were divided into five groups and treated as follows for a period of 21 days: Group I rats, serving as the control, orally received 1 ml/kg body weight of corn oil with administration of same volume of saline. Group II rats were orally administered Zinc phosphide at a dose of 4.57 mg/kg body weight (one-tenth LD50) in corn oil. Group III rats orally received curcumin at a dose of 100 mg/kg body weight. Groups IV and V rats were orally administered curcumin at graded doses of 100 and 200 mg/kg body weight respectively, 2 hours before administration of Zinc phosphide. At the end of the time interval, experimental animals were anesthesized with diethylether and organs (kidney and liver) were harvested for biochemical assays. The oral administration of Zinc phosphide at 4.57 mg/kg body weight for 21 days resulted in a significant increase in hepatic and nephridial malondialdehyde. This index of lipid peroxidation, was accompanied by decreased activity of the antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) followed by a drastic reduction in the non-enzymatic antioxidant indices of reduced glutathione when compared to control. Pre-administration of Curcumin significantly ameliorated zinc phosphide-induced hepatic and nephrotic effects by subduing oxidative stress indices and improving antioxidant status. The result of the present study shows that curcumin has a protective effect against zinc phosphide induced liver and kidney damage in male Wistar rats.

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Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin

Cited by 27 publications

References 74 publications

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

Toxicological Effects of Ethanolic Stem Bark Extract of Xylopia Aethiopica on Testicular Oxidative Stress Markers and Histology of Male Rats

Zinc Phosphide-Induced Hepato-Nephrotoxicity in Wistar Rats: The Ameliorative Role of Curcumin from Curcuma longa Rhizome

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Aluminium phosphide-induced testicular toxicity through oxidative stress in Wistar rats: Ameliorative role of hesperidin

Cited by 27 publications

References 74 publications

Tyrosol prevents AlCl3induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

Tyrosol prevents AlCl3induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

Toxicological Effects of Ethanolic Stem Bark Extract of Xylopia Aethiopica on Testicular Oxidative Stress Markers and Histology of Male Rats

Zinc Phosphide-Induced Hepato-Nephrotoxicity in Wistar Rats: The Ameliorative Role of Curcumin from Curcuma longa Rhizome

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Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway

Tyrosol prevents AlCl₃induced male reproductive damage by suppressing apoptosis and activating the Nrf‐2/HO‐1 pathway