Aluminium Induced Disease in Subjects with and without Renal Failure—Does It Help Us Understand the Role of Aluminium in Alzheimer’s Disease?

Altmann, Paul

doi:10.1016/b978-044450811-9/50026-4

Aluminium and Alzheimer's Disease 2001

DOI: 10.1016/b978-044450811-9/50026-4

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Aluminium Induced Disease in Subjects with and without Renal Failure—Does It Help Us Understand the Role of Aluminium in Alzheimer’s Disease?

Paul Altmann

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Cited by 3 publications

References 197 publications

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Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

2013

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We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.

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Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

2013

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New insights on the picosecond time-resolved fluorescence signatures of metal cation-Morin complexes

Smortsova

Gaillard

Cornard

et al. 2023

Journal of Molecular Liquids

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Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?

Tomljenovic

2011

JAD

336

197

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The brain is a highly compartmentalized organ exceptionally susceptible to accumulation of metabolic errors. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of the elderly and is characterized by regional specificity of neural aberrations associated with higher cognitive functions. Aluminum (Al) is the most abundant neurotoxic metal on earth, widely bioavailable to humans and repeatedly shown to accumulate in AD-susceptible neuronal foci. In spite of this, the role of Al in AD has been heavily disputed based on the following claims: 1) bioavailable Al cannot enter the brain in sufficient amounts to cause damage, 2) excess Al is efficiently excreted from the body, and 3) Al accumulation in neurons is a consequence rather than a cause of neuronal loss. Research, however, reveals that: 1) very small amounts of Al are needed to produce neurotoxicity and this criterion is satisfied through dietary Al intake, 2) Al sequesters different transport mechanisms to actively traverse brain barriers, 3) incremental acquisition of small amounts of Al over a lifetime favors its selective accumulation in brain tissues, and 4) since 1911, experimental evidence has repeatedly demonstrated that chronic Al intoxication reproduces neuropathological hallmarks of AD. Misconceptions about Al bioavailability may have misled scientists regarding the significance of Al in the pathogenesis of AD. The hypothesis that Al significantly contributes to AD is built upon very solid experimental evidence and should not be dismissed. Immediate steps should be taken to lessen human exposure to Al, which may be the single most aggravating and avoidable factor related to AD.

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Aluminium Induced Disease in Subjects with and without Renal Failure—Does It Help Us Understand the Role of Aluminium in Alzheimer’s Disease?

Cited by 3 publications

References 197 publications

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity

New insights on the picosecond time-resolved fluorescence signatures of metal cation-Morin complexes

Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?

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