Aluminium in Alzheimer?s disease: are we still at a crossroad?

Gupta, Veer; Anitha, S; Hegde, Muralidhar L.; Zecca, Luigi; Garruto, Ralph M.; Ravid, Rivka; Shankar, S K; Stein, Reuven; Shanmugavelu, P.; Rao, K. S.

doi:10.1007/s00018-004-4317-3

Cited by 275 publications

(149 citation statements)

References 143 publications

(132 reference statements)

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“…28,29 Although it was mentioned that aluminum might play a role in the pathogenesis of Alzheimer's disease, 30,31 some recent investigations denied this relationship. 32,33 On the other hand, there are few reports about aluminum hypersensitivity.…”

Section: Biocompatibility Of Ti-nb-al Alloy Composing Elementsmentioning

confidence: 99%

Orthodontic Buccal Tooth Movement by Nickel-Free Titanium-Based Shape Memory and Superelastic Alloy Wire

Suzuki

Kanetaka

Shimizu

et al. 2006

The Angle Orthodontist

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Objective: To examine the mechanical properties and the usefulness of titanium-niobium-aluminum (Ti-Nb-Al) wire in orthodontic tooth movement as compared with nickel-titanium (Ni-Ti) wire. Materials and Methods: The load deflection of expansion springs was gauged with an original jig. The gradient of the superelastic region was measured during the unloading process. Expansion springs comprising the two types of alloy wires were applied to upper first molars of rats. The distance between the first molars was measured with micrometer calipers. Results: The force magnitude of the Ti-Nb-Al expansion spring was lower than that of the Ni-Ti expansion spring over the entire deflection range. The initial force magnitude and the gradient in the superelastic region of the Ti-Nb-Al expansion springs were half those of the Ni-Ti expansion springs. Thus, Ti-Nb-Al expansion springs generated lighter and more continuous force. Tooth movement in the Ni-Ti group proceeded in a stepwise fashion. On the other hand, tooth movement in the Ti-Nb-Al group showed relatively smooth and continuous progression. At 17 days after insertion of expansion springs, there were no significant differences between the Ti-Nb-Al and NiTi groups in the amount of tooth movement. Conclusions:These results indicate that Ti-Nb-Al wire has excellent mechanical properties for smooth, continuous tooth movement and suggest that Ti-Nb-Al wire may be used as a practical nickel-free shape memory and superelastic alloy wire for orthodontic treatment as a substitute for Ni-Ti wire.

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Section: Biocompatibility Of Ti-nb-al Alloy Composing Elementsmentioning

confidence: 99%

Orthodontic Buccal Tooth Movement by Nickel-Free Titanium-Based Shape Memory and Superelastic Alloy Wire

Suzuki

Kanetaka

Shimizu

et al. 2006

The Angle Orthodontist

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“…Al is a possible contributing factor in Alzheimer's disease (Campbell, 2002). Evidence for the contribution of Al to Alzheimer's disease (AD) remains contradictory (Flaten, 2001;Gupta et al, 2005). However, epidemiological studies have indicated a link between Al in drinking water and AD and a variety of human and animal studies have implicated learning and memory deficits after Al exposure.…”

Section: Introductionmentioning

confidence: 99%

Effects of Aluminium Chloride Exposure on the Histology of the Cerebral Cortex of Adult Wistar Rats

Buraimoh

Ojo

Hambolu

et al. 2012

JBLS

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AbstractsAluminium (Al) is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes. Human exposure to Al has been increasing over the last decades. Al exposure and neurological impairments demonstrate mixed findings. The cerebral cortex is a sheet of neural tissue that is outer-most to the cerebrum of the mammalian brain and it plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness.The objectives of this study was to investigate the possible effects that aluminium Chloride could have on the histology of cerebral cortex. Total of twenty adult wistar rats were used for this experiment. The wistar rats were divided into five groups; group I was the control, group II received 475mg/Kg, group III received 950mg/kg, group IV received 1,425mg/kg and group V received 1,900mg/kg via oral intubation for a duration of Eight weeks. The wistar rats were humanly sacrificed and the brain was removed and immediately fixed in bouin fluid. The histological observations of the aluminium treated groups revealed extensive neuronal vacuolation and necrosis (neuro-degeneration) of the cerebral cortex of wistar rats.Based on our observations, we therefore conclude that Aluminium chloride exposure has neurodegenerative effects on the histology of cerebral cortex of adult wistar rats especially at higher dose. Therefore, caution should be taken in its usage.

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“…The elemental aluminium does not occur in its pure state but is always combined with other elements such as chloride, hydroxide, silicate, sulphate and phosphate. The wide distribution of this element ensures the potential for causing human exposure and harm [6][7][8][9].Evidence for contribution of aluminium to Alzheimer's disease remains contradictory [10][11]. Epidemiological studies have indicated a link between aluminium in drinking water and Alzheimer's disease (AD) and a variety of human and animal studies have implicated learning and memory deficits after aluminium exposure [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aluminium Chloride Exposure on the Histology of the Liver of Adult Wistar Rats

Buraimoh¹

2012

iosrphr

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ABSTRACT:Aluminium is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes. It presence has so heavily contaminated the environment that exposure to it is virtually inescapable. The liver is the largest gland of the body that processes blood and breaks down nutrients, drugs into forms that are easier to use for the rest of the body. This study was aimed at evaluating the possible effects that aluminium chloride exposure could have on the histology of the liver. Ten wistar rats were used and were divided into five groups; group I was the control, group II received 475mg kg -1 , group III received 950mgkg -1 , group IV received 1,425mg kg -1 and group V received 1,900mg kg -1 via oral intubation for duration of eight weeks. The liver tissues was fixed, processed, stained in H&E and slides viewed under light microscope. Our observations showed that aluminium chloride exposure was detrimental to the liver of wistar rats, as indicated by congested central vein and distorted sinusoids.

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Aluminium in Alzheimer?s disease: are we still at a crossroad?

Cited by 275 publications

References 143 publications

Orthodontic Buccal Tooth Movement by Nickel-Free Titanium-Based Shape Memory and Superelastic Alloy Wire

Orthodontic Buccal Tooth Movement by Nickel-Free Titanium-Based Shape Memory and Superelastic Alloy Wire

Effects of Aluminium Chloride Exposure on the Histology of the Cerebral Cortex of Adult Wistar Rats

Effects of Aluminium Chloride Exposure on the Histology of the Liver of Adult Wistar Rats

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