Effects of Aluminium Chloride Exposure on the Histology of the Liver of Adult Wistar Rats

Buraimoh, Adebayo Adekunle

doi:10.9790/3013-0230525533

Cited by 13 publications

(14 citation statements)

References 30 publications

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“…In addition to periportal fibroplasia, edema, biliary hyperplasia with infiltration of inflammatory cells and hepatocytic vaculation. The current hepatic lesions were parallel to those reported by Kutlubay et al (2007), El-Sayed (2011), Buraimoh et al (2012), Goma andTohamy (2016) andoda (2016). Aluminum nephrotoxicity can occur when the urinary bladder is irrigated with 1% alum to treat bladder hemorrhage so it occurs in patients who have renal insufficiency Phelps et al (1999).…”

Section: Figure (1)supporting

confidence: 69%

Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Saad¹,

Hassieb²,

Oda³

et al. 2018

AJVS

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Key words:aluminum chloride, rabbits, heart, liver, kidneys, Zenker's degenerationThe present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits. Twenty-four apparently healthy male and female rabbits were randomly assigned to four groups. The two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline. The other two Al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg B.W. S/C five times per week for 3 months. At the 6 th weeks and the 12 th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination. The heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as Zenker's degeneration and necrosis of myocardium. The Liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules. The encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts. An additional lesion of severe interstitial nephritis was also seen in some areas. It was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.

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Section: Figure (1)supporting

confidence: 69%

Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Saad¹,

Hassieb²,

Oda³

et al. 2018

AJVS

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“…However, epidemiological studies have indicated a link between Al in drinking water and AD and a variety of human and animal studies have implicated learning and memory deficits after Al exposure. (Buraimoh et al, 2011a;Exley, 2005;Yokel, 2000).It was also postulated by Buraimoh et al, 2011b: that Aluminium chloride exposure has negative effects on behaviour of adult wistar rats (i.e. alter behaviour).…”

Section: Introductionmentioning

confidence: 99%

Effects of Aluminium Chloride Exposure on the Histology of the Cerebral Cortex of Adult Wistar Rats

Buraimoh

Ojo

Hambolu

et al. 2012

JBLS

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AbstractsAluminium (Al) is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes. Human exposure to Al has been increasing over the last decades. Al exposure and neurological impairments demonstrate mixed findings. The cerebral cortex is a sheet of neural tissue that is outer-most to the cerebrum of the mammalian brain and it plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness.The objectives of this study was to investigate the possible effects that aluminium Chloride could have on the histology of cerebral cortex. Total of twenty adult wistar rats were used for this experiment. The wistar rats were divided into five groups; group I was the control, group II received 475mg/Kg, group III received 950mg/kg, group IV received 1,425mg/kg and group V received 1,900mg/kg via oral intubation for a duration of Eight weeks. The wistar rats were humanly sacrificed and the brain was removed and immediately fixed in bouin fluid. The histological observations of the aluminium treated groups revealed extensive neuronal vacuolation and necrosis (neuro-degeneration) of the cerebral cortex of wistar rats.Based on our observations, we therefore conclude that Aluminium chloride exposure has neurodegenerative effects on the histology of cerebral cortex of adult wistar rats especially at higher dose. Therefore, caution should be taken in its usage.

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“…Studies have reported the beneficial effect of Allium cepa on arsenic acid induced-and cadmium-induced hepatic damage in rats [5][6][7]26]. Exposure of human beings to both Allium cepa and aluminum chloride is insurmountable [2].…”

Section: Discussionmentioning

confidence: 99%

“…During normal breathing, at least 1.4 µg of aluminum in particulate was reported to be inhaled per day [3]. With a significant aluminum load, the excretory capacity of the kidney is exceeded leading to deposition of the minerals in various tissues including the liver and consequently resulting in hepatotoxicity [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Ige¹,

Adeniyi²,

Iyalla³

2017

J Biomedical Sci

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Allium cepa (Common Onion), one of the most widely grown crops in world, is believed to possess medicinal potency. The present study was designed to investigate the effect of Allium cepa (ACE) administration on oxidative stress-mediated hepatotoxicity following aluminum chloride (AlCl3) administration. 24 adult male wistar rats weighing 175 g were randomly divided into vehicle-treated (control), ACE, aluminum chloride (AlCl3) and ACE+AlCl3 groups. Rats were given single oral administrations of 100mg/kg body weight of AlCl3 and 1 mL/0.1 kg body weight of ACE for four weeks. When compared with vehicle-treated, AlCl3 administration caused a significant decrease in serum total protein (TP) and an increase in serum levels of alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin. On the other hand, ACE treatment significantly improved serum TP but depressed serum levels of ALT, AST and total bilirubin. There was no significant change in these biomarkers of liver function in ACE+AlCl3 group compared with the vehicle-treated group. Furthermore, while AlCl3 group was characterized by a significant rise in hepatic malondialdehyde (MDA) and a decrease in hepatic superoxide dismutase (SOD) and catalase activities, ACE group exhibited a significant low hepatic MDA and a high hepatic SOD and catalase activities. However, none of these antioxidant markers changed in ACE+AlCl3 group compared with vehicle-treated. Therefore, we conclude that ACE mitigates hepatotoxic effect of AlCl3 administration through regulation of hepatic oxidant/antioxidant system.

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Effects of Aluminium Chloride Exposure on the Histology of the Liver of Adult Wistar Rats

Cited by 13 publications

References 30 publications

Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Histopathologic Study on The Toxic Effect of Aluminium Chloride on the Heart, Liver and Kidneys of Rabbits

Effects of Aluminium Chloride Exposure on the Histology of the Cerebral Cortex of Adult Wistar Rats

Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

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