Aluminium Distribution and Excretion: A Comparative Study of a Number of Chelating Agents in Rats

Gómez, Mercedes; Esparza, José L.; Domingo, José L.; Corbella, J.; Singh, Pramod K.; Jones, Mark M.

doi:10.1111/j.1600-0773.1998.tb01576.x

Cited by 31 publications

(23 citation statements)

References 26 publications

(5 reference statements)

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“…In aqueous solution, numerous molybdenum species are present, whereas the free metal ion does not exist. As usual, MoO 4 2-is chosen as the metal component (M) in the calculations. In aqueous solution above pH 7, MoO 4 2-predominates, whereas below pH 7 some mononuclear species can exist but polyoxomolybdates are the main species.…”

Section: Resultsmentioning

confidence: 99%

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Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives

Santos¹,

Gama²,

Pessoa³

et al. 2007

Eur J Inorg Chem

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The molybdenum(VI) binding properties of a series of 3‐hydroxy‐2‐methyl‐4‐pyridinones (3,4‐HP), namely bis(3,4‐HP)chelators, were investigated in solution and as solids; in particular, the complexation of MoVI with iminobis{acetyl[1‐(3′‐aminopropyl)‐3‐hydroxy‐2‐methyl‐4‐pyridinone]}, IDAPr(3,4‐HP)2, and ethylenediamino‐N,N′‐bis(methylcarboxyl)‐N,N′‐bis{acetyl[1‐(3′‐aminopropyl)‐3‐hydroxy‐2‐methyl‐4‐pyridinone]}, EDTAPr(3,4‐HP)2, as well as three model compounds: 1,2‐dimethyl‐3‐hydroxy‐4‐pyridinone (DFP), iminodiacetic acid (IDA), and ethylenediaminodiacetic acid (EDDA). Solution studies show that the complexation occurs at low pH values by the coordination modes of the hydroxypyridinone moiety, and with the formation of bischelated MoO22+ species. As the pH is increased, hydrolytic processes start with the formation of monochelated MoO3 complexes and is followed by the total recovery of the free ligand, at pH > 8 for most of the systems, but at pH 10 for EDTAPr(3,4‐HP)2. The obtained solid molybdenum complexes showed evidence for the presence of mononuclear species in solution, whereas the dinuclear species, (MoO2)2EDTAPr(3,4‐HP)2, were only detected for the EDTA derivative. Aqueous solution studies were performed by pH–potentiometry, spectrophotometry, 1H NMR and 17O NMR spectroscopy, and solid complex species were characterized by elemental analysis, IR spectroscopy, and ESI‐MS.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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Section: Resultsmentioning

confidence: 99%

“…They have been identified as the main candidates for medical application, either for the control of metal toxicity situations in the body (e.g. Fe [1][2][3] and Al [4][5][6] ), or for clinical diagnosis (e.g. 67,68 Ga, 111 In).…”

Section: Introductionmentioning

confidence: 99%

Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives

Santos¹,

Gama²,

Pessoa³

et al. 2007

Eur J Inorg Chem

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“…In recent years, it has also been shown that both deferoxamine and deferiprone have a comparable effect on Al removal when used in equimolar doses (Elorriaga et al 1992;Gó mez et al 1994Gó mez et al , 1998aGó mez et al & b, 1999. Notwithstanding, although information concerning the effects of deferiprone on Al mobilization in Al-loaded uraemic rats is very scarce (Elorriaga et al 1992;Gó mez et al 1994), in a previous study a remarkable death rate was observed in uraemic rats given deferiprone (subcutaneously or orally) at 1.35 mmol/kg/day for 5 days (Gó mez et al 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Samples of the following tissues were collected: spleen, brain, liver, kidneys and bone (femur). Aluminium concentrations in tissues and urine were analyzed as described previously (Gó mez et al 1998a).…”

Section: Methodsmentioning

confidence: 99%

Age‐Related Differences on Aluminium Mobilization by Chelating Agents in Aluminium‐Loaded Uraemic Rats

Esparza

Gómez

Domingo

et al. 2000

Pharmacology & Toxicology

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The efficacy of deferoxamine, deferiprone, and a combination of these chelating agents in the mobilization and promotion of aluminium (Al) excretion was compared in two age groups of uraemic rats which had previously received Al nitrate nonahydrate intraperitoneally in a daily dose of 45 mg/kg for 5 weeks. At the end of the period of Al exposure, Al-loaded rats of each age (young and adult) group were given one of the following treatments for 5 days: 0.90 mmol/kg/ day of deferoxamine (subcutaneously), 0.90 mmol/kg/day of deferiprone (orally), and 0.45 mmol/kg/day of deferoxamine (subcutaneously) plus 0.45 mmol/kg/day of deferiprone (orally). Control rats were given 0.9% saline (subcutaneously) and deionized water (orally). Total urines were collected 24 hr after each chelator administration. Although young rats treated with deferoxamine, deferiprone, or deferoxamine plus deferiprone showed significant increases in the total amount of Al excreted into urine during 5 consecutive days, the effect of combined administration of deferoxamine and deferiprone was lower than that caused by deferoxamine or deferiprone only. On the other hand, after administration of deferoxamine and deferiprone, a significant reduction of Al was noted only in the liver of young rats, while no significant effects of the chelators were seen in any of the examined tissues of adult animals. The results of the current study show that a combined therapy with deferoxamine and deferiprone (at half-doses of each drug) can also be effective in mobilizing Al from the body of Al-loaded uraemic rats.

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“…and to remove undesirable metal ions [4,5,[8][9][10][11]. Recently in chelation therapy, many candidate compounds have been screened in animal models [11].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mercury in Iron Metabolism in Rats

Saljooghi¹

2011

J Clin Toxicol

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Aluminium Distribution and Excretion: A Comparative Study of a Number of Chelating Agents in Rats

Cited by 31 publications

References 26 publications

Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives

Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives

Age‐Related Differences on Aluminium Mobilization by Chelating Agents in Aluminium‐Loaded Uraemic Rats

The Effect of Mercury in Iron Metabolism in Rats

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