Alumina/graphene/Cu hybrids as highly selective sensor for simultaneous determination of epinephrine, acetaminophen and tryptophan in human urine

Taleb, Masoud; Ivanov, Roman; Bereznev, Sergei; Kazemi, Sayed Habib; Hussainova, Irina

doi:10.1016/j.jelechem.2018.06.013

Cited by 30 publications

(8 citation statements)

References 39 publications

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“…Thus, the amperometric sensor can sense the analyte with superior sensitivity with enhanced current many orders of magnitude greater than DPV. , The performance of the present sensor with the recently reported sensors against ACAP is compared and summarized in Table . When compared to the reported methods, the present sensor offered inspiring sensitivity and LOD with a linear range of detection of 0.1–1900 μM. − ,− …”

Section: Resultsmentioning

confidence: 99%

“…These methods are relatively expensive and time-consuming, require presample preparation, and have very complicated handling procedures. Notwithstanding the above-mentioned analytical techniques, an electrochemical approach is economically viable, portable, quick responding, time-saving, more efficient, of higher sensitivity, excellent selectivity, simplicity, and good practicability for the accurate determination of ACAP. − Moreover, electrochemical sensing devices and chemically modified electrodes have several advantages in vast of areas including proteomic detections, biological sensors, molecular biology, nanotechnology and nanoscience, food and pharmaceutical drug analysis, and agricultural and environmental inspections.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Gowthaman

Lim

Shankar

2019

ACS Appl. Nano Mater.

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Herein, we present the electrochemical scaffold for the quantification of acetaminophen (ACAP) using a silver phosphate nanoparticle (Ag−P NP) fabricated screen-printed carbon electrode (SPCE). The Ag−P NPs were synthesized by a facile method through simply refluxing the reaction mixture of AgNO 3 and Na 2 HPO 4 at 120 °C in the presence of citric acid followed by calcination. The obtained Ag−P NPs were characterized by Fourier transform infrared (FT-IR) and UV− vis diffused reflectance spectroscopies, X-ray diffraction (XRD), and electron microscopic tools. The as-prepared Ag−P NPs exhibited the bandgap energy of 2.2 eV, and the prepared Ag−P NPs have a sphere-like morphology with 13 nm average size. The main strategy of this study lies in providing the electrocatalytic oxidation of ACAP at the surface of the Ag−P NPs modified electrode. The developed sensor was applied to determine ACAP from commercial drugs and human fluids. The Ag-P NPs modified electrode detects ACAP in the linear concentration of 0.1−1900 μM with the lowest detection limit of 0.39 nM (S/N = 3) with the superior sensitivity of 2244.4 μA/μM•cm 2 . Further, the developed sensor showed excellent specificity, sensitivity, reproducibility, and stability compared to the previously reported sensors. Finally, the developed sensor has been exploited to testify the practicability by determining the concentration of ACAP from pharmaceutical samples and human fluids. The synthesized Ag−P NPs were also utilized for antibacterial studies against Staphylococcus aureus and Aspergillus niger.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Gowthaman

Lim

Shankar

2019

ACS Appl. Nano Mater.

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“…Adrenaline (ADR) is a neurotransmitter, a hormone, and a prescription drug. ADR is a well-known catecholamine secreted by the endocrine system 9 , 10 . ADR content in blood is linked to a slew of physiological activities 11 .…”

Section: Introductionmentioning

confidence: 99%

A novel, extreme low-cost poly (Erythrosine) modified pencil graphite electrode for determination of Adrenaline

Sukanya¹,

Swamy

Shashikumara

et al. 2023

Sci Rep

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A simple, novel, and less cost yellow (Erythrosine) modified pencil graphite electrode (Po-ERY/MGPE) was successfully fabricated via electropolymerization method using cyclic voltammetric techniques. The fabricated Po-ERY/MGPE opted as a sensor for the detection of Adrenaline (ADR) in 0.2 M PBS (7.4 pH). This reported senor displayed excellent electrocatalytic activity, increased sensitivity, high stability, superior electron transfer kinetics in the oxidation of ADR once relative to BGPE. The significance of pH, scan rate, and impact of concentration was assessed at the sensor. As per the pH and scan rate study, redox routes carry the same number of electrons and protons, and electro-oxidation of ADR was adsorption controlled respectively. The LOD of ADR was found to be 0.499 µM. The DPV data indicate that there is a significant peak divergence among ADR and uric acid (UA) which could make it easier to determine them alone and simultaneously on the sensor. The described method has been employed for the determination of ADR in injection sample. Good recovery values indicate the efficacy and applicability of the sensor in detecting ADR.

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“…To mention briefly, Para is a phenolic compound that becomes one of the main drugs in day-to-day human’s life owing to its antipyretic and analgesic activities. , In addition, Para has effective therapeutic capacity in neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases . Nevertheless, if more than the usual therapeutic dose is used, such as more than 20 μg/mL, Para can accumulate in the body and kill the liver, skin, and pancreas .…”

Section: Introductionmentioning

confidence: 99%

“… 12 , 13 In addition, Para has effective therapeutic capacity in neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases. 14 Nevertheless, if more than the usual therapeutic dose is used, such as more than 20 μg/mL, Para can accumulate in the body and kill the liver, skin, and pancreas. 15 Moreover, after administration of this drug, a major portion is used to treat diseases but little amount is excreted in urine, 16 and thus, it becomes a pollutant to soils and waters.…”

Section: Introductionmentioning

confidence: 99%

Design of an Efficient Tin Selenide-Based Ternary Nanocomposite Electrode for Simultaneous Determination of Paracetamol, Tryptophan, and Caffeine

Murugan

Kumar²

2022

ACS Omega

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Electrochemical sensors play an essential role in the medical arena through assessing the drug quality and diagnosing diseases. The design of sensors relies on the electroactive properties of the material meticulously chosen to modify the electrode. Here in this work, a facile ternary SnSe/TiO 2 @GO electroactive nanocomposite was prepared using tin selenide (SnSe) in combination with titanium dioxide (TiO 2 ) embedded on graphene oxide (GO). The ternary nanocomposite was characterized by X-ray diffraction, Raman, FT-IR, and X-ray photoelectron spectroscopy, energy dispersive analysis, and scanning electron microscopy. The ternary nanocomposite was then drop-coated on the GC electrode to form the SnSe/TiO 2 @ GO-GC electrode. Its electrochemical activity was demonstrated for simultaneous determination of paracetamol, tryptophan, and caffeine. The synergetic interaction of the components and their innate virtue showed enriched electrocatalytic activity such as a decrease in overpotential, enhancement in electron transfer, greater sensing ability and selectivity, wide linear range, and low detection limit toward the chosen analytes. Broad linear ranges of concentrations, 0.0089−410, 0.0136−87.66, and 0.0160−355 μM, with detection limits of 0.0030, 0.0053, and 0.0065 μM for paracetamol, tryptophan, and caffeine, respectively, were noticed. The electrode also displayed high selectivity, stability, repeatability, and reproducibility. Importantly, the study was successful for detection and quantification of the above components in real samples of blood serum, pharmaceutical formulations, and beverages.

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Alumina/graphene/Cu hybrids as highly selective sensor for simultaneous determination of epinephrine, acetaminophen and tryptophan in human urine

Cited by 30 publications

References 39 publications

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

A novel, extreme low-cost poly (Erythrosine) modified pencil graphite electrode for determination of Adrenaline

Design of an Efficient Tin Selenide-Based Ternary Nanocomposite Electrode for Simultaneous Determination of Paracetamol, Tryptophan, and Caffeine

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