Altersabhängigkeit des alveolo-arteriellen O&lt;sub&gt;2&lt;/sub&gt;-Partialdruckgradienten bei Schwerarbeit in Normoxie, Hypoxie und Hyperoxie

Scherrer, M; Birchler, A.

doi:10.1159/000192518

Cited by 2 publications

(5 citation statements)

References 18 publications

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“…value lower in the young than in the middle-aged group. The tendency to a decreasing PaOt and increasing PA-aOI with age is in agreement with the findings of other authors (15,27,45,47,54,65). In our series the difference between the two groups can be explained by greater ventilatory maldistribution and veno-arterial shunting, possibly including a higher avo% difference (not measured) in the middle-aged group, which was observed during 100% 0, breathing in the same body posture.…”

Section: Discussionsupporting

confidence: 93%

“…Finally the blood sampling period might not be representative for steady state conditions During hyperoxia (100% 0,) signs of greater ventilatory inhomogeneity were seen in the older group. Assuming that the avo% difference is the same in both groups, veno-arterial shunting is more prominent in the older group, as has also been found by other authors (15,27,45) but not under conditions of exercise by Scherrer & Birchler (54). k0…”

Section: Discussionsupporting

confidence: 62%

“…The mean P..-ao2 increased in the young and decreased in the middle-aged group with change in posture. Several other authors have found a larger decrease in PaO, and increase in PA-aOz in the sitting posture than we did (45,54). As the increases in VE, VA and PA^^ were about the same in both groups, the differences are due to PaO, values.…”

Section: Discussioncontrasting

confidence: 48%

“…Simultaneously with increased VA in both groups the increase of VD and V,/VT in the young group is smaller than in the middle-aged group, where the simultaneous H R and BP increases are slight. It has been suggested by Scherrer et al (54) that the higher ventilatory increase in the old might be due to a higher sensitivity of the respiratory centre to hypoxia on account of cerebral arteriosclerotic changes. As our middle-aged group is considerably younger than the "old" group of Scherrer et al (54) we consider several mechanisms to be involved, but an analysis of this question was beyond the scope of the present study.…”

Section: Discussionmentioning

confidence: 96%

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Gas Exchange in Two Male Age Groups in Relation to Inspiratory Oxygen Fraction, Physical Exercise and Body Posture

Bäcklund¹,

Tammivaara-Hilty²

1972

Upsala Journal of Medical Sciences

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Two groups of male subjects, mean age 25 and 50 years, were studied at rest supine during air breathing, 15-11 and 100% Oa breathing, sitting at rest and during exercise up to maximal work load, and supine during a constant submaximal work load combined with D L~~ measurements. At rest supine, the mean and range of PaoI was 90.2 (79-97) in the young and 78.2 (68-88) mmHg in the middle-aged. PA-^^^ was 4.3 (-1-14) and 23.4 (15-33) mmHg, respectively. Corresponding SaOp values were 97.3 (95.7-99.0) and 94.5 (91.7-98.6) per cent. During hypoxia, the Pao, and PA-aOl values were lower in the young than the middle-aged. During hyperoxia the PaOI and PA-aol were 611 (574-644) and 48(31-60) in the young and 573 (492-612) and 93 (60-108) mmHg in the middle-aged, respectively. VD and VD/VT were constantly higher in the middle-aged. At max. work load, no great difference in Paoz (87.5 and 85.8 mmHg) or SaOI (95.8 and 94.2 %) was found. The mean D L~~ values were 39.2 (young) and 36.8 (middleaged) ml/mmHg.min, as measured at VO, 1490 and 1 656 ml/min, and at VE 35.9 and 43.6 Ijmin, respectively.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 62%

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 96%

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Gas Exchange in Two Male Age Groups in Relation to Inspiratory Oxygen Fraction, Physical Exercise and Body Posture

Bäcklund¹,

Tammivaara-Hilty²

1972

Upsala Journal of Medical Sciences

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“…Turino et al [1959] found no significant increase of Dlco in a lung in which the blood flow was increased by ligature of the contralateral pulmonary artery; and Ross et al [1959] [Scherrer and Birchler, 1967]. In point of fact, during physical exercise, we did find in our subjects a linear correlation between the increase of D lco and the reduction of Pvo2 (fig.…”

Section: Discussionsupporting

confidence: 50%

Correlations between Lung-Transfer Factor, Ventilation, and Cardiac Output during Exercise

Rampulla¹,

Marconi²,

Beulcke³

et al. 1976

Respiration

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In nine healthy and young subject of either sex, undergoing three or four rounds of muscular exercise of increasing severity on a bicycle ergometer, the authors investigated the behavior of the lung transfer factor (DL_CO), pulmonary ventilation (V), alveolar ventilation (Va), and cardiac output (Q). In all instances they found a positive linear correlation between DL_CO and oxygen consumption (VO₂), at least up to 70 % of maximum oxygen consumption (VO_2max) (r = 0.935; p < 0.001). Dl_CO was found to increase linearly as a function of increasing V (r = 0.898; p < 0.001) and even more so of increasing Va (r = 0.919; p < 0.001). Also the relationship between Dl_CO and Q appeared linear in all subjects (r = 0.926; p < 0.001). On the other hand, individual DL_CO values showed considerable scatter at equal VO₂, V, V_A, and Q values. Among the factors responsible for the increase of DL_CO during muscular exercise, in addition to increased ventilation and cardiac output, the authors suggest the possible role of the greater desaturation of mixed venous blood and variations of hemoglobin affinity for CO.

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Altersabhängigkeit des alveolo-arteriellen O<sub>2</sub>-Partialdruckgradienten bei Schwerarbeit in Normoxie, Hypoxie und Hyperoxie

Cited by 2 publications

References 18 publications

Gas Exchange in Two Male Age Groups in Relation to Inspiratory Oxygen Fraction, Physical Exercise and Body Posture

Gas Exchange in Two Male Age Groups in Relation to Inspiratory Oxygen Fraction, Physical Exercise and Body Posture

Correlations between Lung-Transfer Factor, Ventilation, and Cardiac Output during Exercise

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