volume 11, issue 11, Pe0166433 2016
DOI: 10.1371/journal.pone.0166433
View full text
Has correction Has correction 2017-03-30Has erratum

Abstract: BackgroundAlternatively activated (M2) macrophages are phenotypically characterized by the expression of specific markers, mainly macrophage scavenger receptors (CD204 and CD163) and mannose receptor-1 (CD206), and participate in the fibrotic process by over-producing pro-fibrotic molecules, such as transforming growth factor-beta1 (TGFbeta1) and metalloproteinase (MMP)-9. Endothelin-1 (ET-1) is implicated in the fibrotic process, exerting its pro-fibrotic effects through the interaction with its receptors (ET…

Expand abstract
Editorial notices