Alternative treatment of gluteofemoral fistulas using honey: a case report

Vlcekova, Paulina; Krutakova, Barbora; Takáč, Peter; Kozánek, Milan; Salus, Juraj; Majtán, Juraj

doi:10.1111/j.1742-481x.2011.00844.x

Cited by 12 publications

(6 citation statements)

References 12 publications

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“…However, in other study, FHH of the same origin enhanced viability of breast cancer (MCF‐7) cells and did not show significant effect on prostate cancer (PC‐3) cells . On the other hand, in clinical conditions, FHH has been successfully applied to treat infected gluteo‐femoral fistulas and in prophylaxis of endophthalmitis …”

Section: Introductionmentioning

confidence: 95%

“…[4] However, in other study, FHH of the same origin enhanced viability of breast cancer (MCF-7) cells and did not show significant effect on prostate cancer (PC-3) cells. [15] On the other hand, in clinical conditions, FHH has been successfully applied to treat infected gluteo-femoral fistulas [16] and in prophylaxis of endophthalmitis. [17] Since physical-chemical properties and activity of the honey types depends mostly on the botanical origin, correct classification and methods allowing confirmation and standardization of different varieties are very important, especially for the potential medicalgrade honeys.…”

Section: Introductionmentioning

confidence: 99%

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Screening of Polish Fir Honeydew Honey Using GC/MS, HPLC‐DAD, and Physical‐Chemical Parameters: Benzene Derivatives and Terpenes as Chemical Markers

Kuś

Jerković

Marijanović

et al. 2017

Chemistry & Biodiversity

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GC/MS of headspace solid phase micro extraction (HS-SPME) and solvent extractives along with targeted HPLC-DAD of Polish fir (Abies alba Mill.) honeydew honey (FHH), were used to determine the chemical profiles and potential markers of botanical origin. Additionally, typical physical-chemical parameters were also assigned. The values determined for FHH were: conductivity (1.2 mS/cm), water content (16.7 g/100 g), pH (4.5), and CIE chromaticity coordinates (L* = 48.4, a* = 20.6, b* = 69.7, C* = 72.9, and h° = 73.5). FHH contained moderate-high total phenolic content (533.2 mg GAE/kg) and antioxidant activity (1.1 mmol TEAC/kg) and (3.2 mmol Fe /kg) in DPPH and FRAP assays. The chemical profiles were dominated by source plant-originated benzene derivatives: 3,4-dihydroxybenzoic acid (up to 8.7 mg/kg, HPLC/honey solution), methyl syringate (up to 14.5%, GC/solvent extracts) or benzaldehyde (up to 43.7%, GC/headspace). Other markers were terpenes including norisoprenoid (4-hydroxy-3,5,6-trimethyl-4-(3-oxobut-1-enyl)cyclohex-2-en-1-one, up to 20.3%, GC/solvent extracts) and monoterpenes, mainly linalool derivatives (up to 49%, GC/headspace) as well as borneol (up to 5.9%, GC/headspace). The application of various techniques allowed comprehensive characterisation of FHH. 4-Hydroxy-3,5,6-trimethyl-4-(3-oxobut-1-enyl)cyclohex-2-en-1-one, coniferyl alcohol, borneol, and benzaldehyde were first time proposed for FHH screening. Protocatechuic acid may be a potential marker of FFH regardless of the geographical origin.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Screening of Polish Fir Honeydew Honey Using GC/MS, HPLC‐DAD, and Physical‐Chemical Parameters: Benzene Derivatives and Terpenes as Chemical Markers

Kuś

Jerković

Marijanović

et al. 2017

Chemistry & Biodiversity

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“…107 Recent studies 108 compared the clinical and mycological cure rates of a novel mixture consisting of honey and yogurt with local antifungal agents for treating patients with vulvo-vaginal candidiasis during pregnancy, and obtained very promising results. 107 Recent studies 108 compared the clinical and mycological cure rates of a novel mixture consisting of honey and yogurt with local antifungal agents for treating patients with vulvo-vaginal candidiasis during pregnancy, and obtained very promising results.…”

Section: Other Applications Of Honey and Propolis In Human Health Honeymentioning

confidence: 99%

The Role of Honey and Propolis in the Treatment of Infected Wounds

Pascoal

Feás

Dias

et al. 2014

Microbiology for Surgical Infections

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PropolisPropolis (bee glue) is a beehive product prepared by bees of the Apis mellifera species, using resinous substances collected from various plants. 15,16 These substances are mixed with the β-glycosidase enzyme of their saliva, partially digested, and added to bee wax to form the final product.This product, commonly referred as a "natural antibiotic", has an important role in protecting, reinforcing and repairing the hives. In addition, any invaders are wrapped in propolis and die by asphyxia, then the bodies are preserved, which prevents the putrefaction of the honeycomb. 17À19 It is also a barrier to molds and yeasts, bacteria, viruses, and rain. Propolis is mainly composed of resins (50%), waxes (30%), essential oils (10%), pollen (5%), and other organic compounds (5%), among which are phenolic compounds, esters, flavonoids, terpenes, aromatic aldeydes and alcohols. 20À23 However, it is worth mentioning that this composition differs significantly with botanical and geographical origin and depends on climatic conditions, terrain, water availability and other environmental factors. 18,24À28 It has been reported that this product has several pharmacological properties, such as antibiotic, anti-neoplastic, anti-inflammatory, 26 anti-diarrheatic, antimicrobial, 29,30 antiviral, 31 antioxidant, 32 hepatoprotective, cardiostatic, 33 antitumoral, 23,34 anti-ulcerus and immunostimulatory activity. 35,36 Other studies highlight its efficiency as an anti-HIV-1, 37 anti-neurodegenerative 38 and anti-tuberculosis agent. 39 Due to these medicinal properties, propolis is generating increasing interest from the pharmaceutical, food and cosmetic industries, and it is currently being introduced in products for human consumption, such as drinks and food additives. 32,40 PHENOLIC AND FLAVONOID COMPOUNDS HoneyPhenolic compounds are one of the most important groups of plant secondary metabolites, comprising at least 8000 different known structures. Their chemical structures range from simple phenolic molecules to high molecular weight polymers of approximately 30000 Da. 41 These compounds are reported to exhibit anticarcinogenic, anti-inflammatory, anti-atherogenic, anti-thrombotic, immune modulating, analgesic, antineoplatic behavior, antiviral activity, antiulcer properties, hormone, antibiotic and cardiovascular activities, among others, and exert these functions as antioxidant activities. 42,43 In addition, flavonoids inhibit lipid peroxidation, platelet aggregation, capillary permeability and the activity of enzyme systems including cyclo-oxygenase and lipoxygenase. 10,44 The honey phenolics and the flavonoids present in honey are divided into three classes with similar structure; flavonols, flavones and flavanones. These are important due to their contribution to honey color, taste and flavor and also due to their beneficial effects on health. In honey, propolis and royal jelly, most of the phenolic compounds are present in the form of flavonoids, whose concentration depends on various factors, including the plant spe...

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“…The antibacterial and antibiofilm activity of honeydew honey is comparable to manuka honey, which is currently used as medical-grade honey in clinical applications. Furthermore, a Slovak fir honeydew honey has been successfully clinically tested for the treatment of infected gluteo-femoral fistulas 9 , lower leg ulcers 10 , contact lens-induced corneal ulcers 11 , and as a prophylactic agent for endophthalmitis 12 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals-mediated production of hydrogen peroxide is crucial for high antibacterial activity of honeydew honey

Bucekova

Buriova

Pekárik

et al. 2018

Sci Rep

Self Cite

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Honeydew honey is increasingly valued due to its pronounced antibacterial potential; however, the underlying mechanism and compounds responsible for the strong antibacterial activity of honeydew honey are still unknown. The aim of this study was to investigate the inhibition of bacterial growth of 23 honeydew honey samples. Activity of bee-derived glucose oxidase (GOX) enzyme, the content of defensin-1 (Def-1) and hydrogen peroxide (H2O2), and total polyphenol content were determined in the 23 honey samples. Our results demonstrated that antibacterial activity of honeydew honey was equivalent to medical-grade manuka and kanuka honey and was abolished by catalase. Although H2O2 is an important factor in the inhibition of bacterial growth, polyphenolic compounds and their interaction with H2O2 are the key factors responsible for high antibacterial activity of honeydew honey. In addition, our results indicated that the antibacterial activity of honeydew honey is not dependent on GOX-mediated production of H2O2 or the presence of Def-1.

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Alternative treatment of gluteofemoral fistulas using honey: a case report

Cited by 12 publications

References 12 publications

Screening of Polish Fir Honeydew Honey Using GC/MS, HPLC‐DAD, and Physical‐Chemical Parameters: Benzene Derivatives and Terpenes as Chemical Markers

Screening of Polish Fir Honeydew Honey Using GC/MS, HPLC‐DAD, and Physical‐Chemical Parameters: Benzene Derivatives and Terpenes as Chemical Markers

The Role of Honey and Propolis in the Treatment of Infected Wounds

Phytochemicals-mediated production of hydrogen peroxide is crucial for high antibacterial activity of honeydew honey

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