Alternative sugars as potential carriers for dry powder inhalations

Steckel, Hartwig; Bolzen, Nina

doi:10.1016/j.ijpharm.2003.10.039

Cited by 145 publications

(67 citation statements)

References 9 publications

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“…152,153 A disadvantage of lactose monohydrate, a reducing sugar, as a sugar carrier and/or excipient in the solid-state is that it participates in Maillard decomposition reactions with certain small molecular weight pulmonary drugs (eg, budesonide, formoterol), proteins and peptides. 154 Recently, D-mannitol, a nonreducing sugar alcohol, whose molecular structure is shown in Figure 4c, has …”

Section: Spray-dryingmentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

401

269

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Section: Spray-dryingmentioning

confidence: 99%

Nanomedicine in pulmonary delivery

Mansour¹,

Rhee²,

Wu³

2009

IJN

401

269

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“…In a recent study, several carriers such as mannitol, sorbitol, maltitol, and xylitol, were assessed and it was concluded that mannitol is the best candidate for dry powder inhaler formulation, given that the others showed limited dispersability. 168 Techniques used to produce a respirable formulation are: supercritical fluid technology, spray-freeze drying, freeze-drying, and lyophilizing followed by milling/jet milling or spray-drying. [169][170][171][172][173] Moreover, it has been observed that lactose enhances the uptake of polylysine into airway cells, and this has been shown to be a method of increasing intracellular localization of proteins and peptides.…”

Section: Carbohydratesmentioning

confidence: 99%

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Zarogoulidis

Chatzaki²,

Porpodis³

et al. 2012

IJN

166

160

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Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy and its advantages and disadvantages are presented. Regional chemotherapy to the lung parenchyma for lung cancer is feasible and efficient. Safety depends on the chemotherapy agent delivered to the lungs and is dose-dependent and time-dependent. Further evaluation is needed to provide data regarding early lung cancer stages, and whether regional chemotherapy can be used as neoadjuvant or adjuvant treatment. Finally, inhaled chemotherapy could one day be administered at home with fewer systemic adverse effects.

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“…The particle-particle interaction forces have to be sufficiently strong that fine API particles can adhere with the carriers or form large agglomerates to be transported, but weak enough that they can be detached or dispersed by a deagglomeration process and thus allow the delivery of the API particles into the respiratory tracts and lungs. Therefore, particle-particle interactions play a significant role in controlling the performance of DPIs and hence many studies have been performed to explore the dependency of these interactions on particle size [7,8], material properties [9,10], particle concentration [11,12], particle morphology [13,14], particle surface roughness [15,16], storage conditions [17,18], surface area [19], density and porosity [20], and crystal form [21]. For example, Kaialy et al [7] experimentally examined the influence of the particle size of lactose carrier on the DPI performance and demonstrated that the DPI performance improved with decreasing carrier particle size.…”

Section: Introductionmentioning

confidence: 99%

DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development

Yang

Adams

2013

Granular Matter

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Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method (DEM), which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criterion is proposed to determine the lowest impact velocity at which two elastic autoadhesive spherical particles will rebound from each other during impact. Furthermore, the process of fine API particles adhering to a large carrier in a vibrating container is investigated. It was found that there is an optimal amplitude and frequency for the vibration velocity that can maximise the number of particles contacting with the carrier (i.e. the contact number). The impact number and detachment number during the vibration process both increase with increasing vibration amplitude and frequency while the sticking efficiency decreases as the amplitude and frequency is increased.

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Alternative sugars as potential carriers for dry powder inhalations

Cited by 145 publications

References 9 publications

Nanomedicine in pulmonary delivery

Nanomedicine in pulmonary delivery

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

DEM analysis of particle adhesion during powder mixing for dry powder inhaler formulation development

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