Alternative splicing at exon 28 of the <i> acetyl‐coenzyme A carboxylase α</i> gene in adult pigs and embryos

Gallardo, David; Cánovas, E.; López‐Béjar, Manel; Ramírez, Óscar; Pena, Ramona N.; Quintanilla, Raquel; Amills, Marcel

doi:10.1111/j.1365-2052.2008.01709.x

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…As previously reported by Gallardo et al . 35,36 , a total of 345 Duroc barrows belonging to 5 half-sib families and distributed in 4 fattening batches were selected from a commercial pig line, devoted to high quality meat production. This line is characterized by its high content of intramuscular fat, a feature that results in the improvement of meat juiciness and taste, hence conferring a better consumer acceptance 37 .…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs

Mármol-Sánchez

Quintanilla

Cardoso

et al. 2019

Sci Rep

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The genetic factors determining the phenotypic variation of porcine fatness phenotypes are still largely unknown. We investigated whether the polymorphism of eight genes ( MIGA2 , CRY2 , NPAS2 , CIART , ARNTL2 , PER1 , PER2 and PCK1 ), which display differential expression in the skeletal muscle of fasted and fed sows, is associated with the variation of lipid and mRNA expression phenotypes in Duroc pigs. The performance of an association analysis with the GEMMA software demonstrated that the rs330779504 SNP in the MIGA2 gene is associated with LDL concentration at 190 days (LDL 2 , corrected P -value = 0.057). Moreover, the rs320439526 SNP of the CRY2 gene displayed a significant association with stearic acid content in the longissimus dorsi muscle (LD C18:0, corrected P -value = 0.015). Both SNPs were also associated with the mRNA levels of the corresponding genes in the gluteus medius skeletal muscle. From a biological perspective these results are meaningful because MIGA2 protein plays an essential role in mitochondrial fusion, a process tightly connected with the energy status of the cell, while CRY2 is a fundamental component of the circadian clock. However, inclusion of these two SNPs in chromosome-wide association analyses demonstrated that they are not located at the peaks of significance for the two traits under study (LDL 2 for rs330779504 and LD C18:0 for rs320439526), thus implying that these two SNPs do not have causal effects.

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Section: Methodsmentioning

confidence: 99%

Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs

Mármol-Sánchez

Quintanilla

Cardoso

et al. 2019

Sci Rep

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Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism

Cui¹,

Shen²,

GaoWang³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The ratio of Bacteroidetes and Firmicutes bacterial groups in the gut can affect the ability to absorb nutrients. We investigated the effect of probiotic Bacillus subtilis supplementation of diets on growth performance, fat deposition, blood lipids, copy numbers, and percentage of Bacteroidetes and Firmicutes in cecal contents, as well as mRNA expression of key lipid metabolism enzymes in the liver and adipose tissue of finishing pigs. Twenty-four Duroc x Meishan crossbreed 8-week-old pigs (10.28 ± 0.59 kg) were randomly allocated to two dietary treatments: maize-soybean mealbased diets with B. subtilis (probiotic group) and without B. subtilis (control group). The probiotic diet led to a significant increase in the average daily gain and feed conversion ratio of pigs weighing 10 to 110 kg. The mean backfat depth was increased while leaf lard weights were decreased by probiotic supplementation. Ingestion of probiotics decreased the serum triglyceride and glucose concentrations, but did not change the levels of total cholesterol and free fatty acids in the serum. The mRNA expressions of fatty acid synthase (FAS) and acetylCoA carboxylase α (ACCα) in the liver were down-regulated by the dietary probiotic supplement. Conversely, the gene expressions of FAS and ACCα in the adipose tissue increased. The probiotic diet decreased the copy numbers and percentage of Bacteroidetes, while it increased the percentage of Firmicutes in the cecal contents. We conclude that the addition of B. subtilis improves growth performance and up-regulates lipid metabolism in subcutaneous fat of finishing pigs. We conclude that B. subtilis affects lipid metabolism through regulation of the proportion of Bacteroidetes and Firmicutes in the gut.

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Alternative splicing at exon 28 of the acetyl‐coenzyme A carboxylase α gene in adult pigs and embryos

Cited by 2 publications

References 3 publications

Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs

Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs

Effect of dietary Bacillus subtilis on proportion of Bacteroidetes and Firmicutes in swine intestine and lipid metabolism

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