Alternative sampling strategies for the assessment of biomarkers of exposure

Delahaye, Lisa; Janssens, Bram; Stove, Christophe

doi:10.1016/j.cotox.2017.05.003

Cited by 12 publications

(13 citation statements)

References 67 publications

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“…DBS have been applied in a wide range of applications in toxicology, covering fields as toxicokinetics, epidemiology, environmental, and forensic toxicology [7][8][9]13]. Analytes measured in this context comprise (markers of) substances of abuse, environmental contaminants, and (trace) elements [7][8][9].…”

Section: Toxicologymentioning

confidence: 99%

Section: Toxicologymentioning

confidence: 99%

“…DBS offer the potential to study biomarkers of exposure, including DNA adducts and protein adducts [13]. Several protein adductsprimarily with albumin and hemoglobinhave already been quantified using DBS [13]. The features associated with DBS sampling and handling make DBS-based adduct monitoring particularly attractive for large-scale epidemiological studies, an application field that will likely continue to grow in future [13].…”

Section: Toxicologymentioning

confidence: 99%

“…Examples include the follow-up of problematic drinkers (via direct alcohol markers) or drug users, where supervised sampling may be done, as well as follow-up of trace elements (e.g. in prosthesis patients) or of biomarkers of exposure in epidemiological surveys [7][8][9]13,14]. Although the sensitivity offered by the newest generation of analytical instrumentation is in many cases sufficient, for some applications an extra level may be warranted.…”

Section: Expert Opinionmentioning

confidence: 99%

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Dried blood spots in therapeutic drug monitoring and toxicology

Velghe

Troyer

Stove

2017

Expert Opinion on Drug Metabolism & Toxicology

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Section: Toxicologymentioning

confidence: 99%

Section: Toxicologymentioning

confidence: 99%

Section: Toxicologymentioning

confidence: 99%

Section: Expert Opinionmentioning

confidence: 99%

See 2 more Smart Citations

Dried blood spots in therapeutic drug monitoring and toxicology

Velghe

Troyer

Stove

2017

Expert Opinion on Drug Metabolism & Toxicology

Self Cite

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“…For a more extended historical window, segmental hair analysis could be used or, alternatively, adducts in blood could be monitored. 134,135 Many of the toxicants listed in Table 1 will be converted to reactive intermediates in the liver, which will form covalent adducts with macromolecules such as DNA and proteins. As both haemoglobin and albumin are highly abundant proteins, many groups have focused on adducts with these proteins to document exposure to toxicants, even when these toxicants or their metabolites are no longer detectable in blood or urine.…”

Section: Assessment Of Exposurementioning

confidence: 99%

EASL Clinical Practice Guideline: Occupational liver diseases

Colombo¹,

Vecchia²,

Lotti³

et al. 2019

Journal of Hepatology

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A variety of chemicals have been linked to occupational liver diseases, including several solvents and mixtures thereof, pesticides, and metals. Workplace exposures have been associated with virtually the entire spectrum of acute and chronic liver diseases. However, their prevalence is inadequately quantified and their epidemiology limited. Occupational liver diseases may result from high accidental or from prolonged lower level exposures. Whereas the former is uncommon and easily recognised, the latter are relatively more frequent but often overlooked because they may display normal values of conventional markers, have an insidious onset and be asymptomatic or be obfuscated and confounded by concurrent conditions. In addition, specific tests of toxicity are not available, histopathology may not be revealing and the assessment of internal dose of chemicals is usually not decisive. Given these circumstances, the diagnosis of these liver disorders is challenging, one of exclusion and often requires an interdisciplinary approach. These recommendations offer a classification of the type of liver injuries associated with occupational exposures-based in part on the criteria for drug-induced liver injury-a grading of their severity, and the diagnostic and preventive criteria for chemically induced occupational liver disease.

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Is the hematocrit still an issue in quantitative dried blood spot analysis?

Velghe

Delahaye

Stove

2019

Journal of Pharmaceutical and Biomedical Analysis

Self Cite

158

107

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Hematocrit-related issues remain a major barrier for (regulatory) acceptance of the classical dried blood spot (DBS) analysis in the bioanalytical and clinical field. Lately, many attempts to cope with these issues have been made. Throughout this review, an overview is provided on new strategies that try to cope with this hematocrit effect (going from avoiding to minimizing), on methods estimating a DBS volume, and on methods estimating or measuring the hematocrit of a DBS. Although many successful strategies have been put forward, a combination of different technologies still provides the most complete solution. Therefore, further efforts and the availability of a straightforward guideline for analytical and clinical method validation should help to overcome the hurdles still associated with DBS sampling.

show abstract

Alternative sampling strategies for the assessment of biomarkers of exposure

Cited by 12 publications

References 67 publications

Dried blood spots in therapeutic drug monitoring and toxicology

Dried blood spots in therapeutic drug monitoring and toxicology

EASL Clinical Practice Guideline: Occupational liver diseases

Is the hematocrit still an issue in quantitative dried blood spot analysis?

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