Alternative Pharmaceutical Formulation for Oral Administration of Rifampicin

Halicki, Priscila Cristina Bartolomeu; Hädrich, Gabriela; Boschero, Raphael Aparecido; Ferreira, Laís A.; Groll, Andréa von; Silva, Pedro Eduardo Almeida da; Dora, Cristiana Lima; Ramos, Daniela Fernandes

doi:10.1089/adt.2018.874

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…Various nanotechnology-based strategies have been proposed to develop more effective and patient-compliant medicines for TB treatment, including targeting infection reservoirs and overcoming drug resistance [ 37 ]. A child-friendly nanoemulsion containing rifampicin has shown promise in increasing drug bioavailability and reducing treatment failure in pediatric TB patients [ 39 ]. With increased institutional support, the integration of nanomedicine and genomic research holds the potential to achieve TB elimination by 2050 [ 38 ].…”

Section: Infectious Disease Management and Treatmentmentioning

confidence: 99%

“…Nanofabricated biosensors show high sensitivity in detecting bacterial infections, contributing to innovative approaches in combatting pediatric infectious diseases [ 29 ]. Furthermore, nanotechnology has contributed in the diagnosis and treatment of tuberculosis (TB) and human immunodeficiency virus (HIV) infections, improving targeted drug delivery, diagnostics, and treatment outcomes [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Potential of Nanotechnology in Pediatric Healthcare: Advances, Challenges, and Future Directions

Omidian

Mfoafo

2023

Pharmaceutics

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The utilization of nanotechnology has brought about notable advancements in the field of pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and tissue engineering. Nanotechnology involves the manipulation of materials at the nanoscale, resulting in improved drug effectiveness and decreased toxicity. Numerous nanosystems, including nanoparticles, nanocapsules, and nanotubes, have been explored for their therapeutic potential in addressing pediatric diseases such as HIV, leukemia, and neuroblastoma. Nanotechnology has also shown promise in enhancing disease diagnosis accuracy, drug availability, and overcoming the blood–brain barrier obstacle in treating medulloblastoma. It is important to acknowledge that while nanotechnology offers significant opportunities, there are inherent risks and limitations associated with the use of nanoparticles. This review provides a comprehensive summary of the existing literature on nanotechnology in pediatric medicine, highlighting its potential to revolutionize pediatric healthcare while also recognizing the challenges and limitations that need to be addressed.

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Section: Infectious Disease Management and Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Nanotechnology in Pediatric Healthcare: Advances, Challenges, and Future Directions

Omidian

Mfoafo

2023

Pharmaceutics

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“…The MIC value for the developed NE was 7.8 μg/mL, while the free drug was 1024 μg/mL. The incorporation of the drug within the lipidic framework of NE led to a decline in drug degradation, whereby improving the pharmacological drug profile [64]. Shobo and associates developed NE of pretomanid, which was to be administered intranasally.…”

Section: Nanoemulsionmentioning

confidence: 99%

Nano-based anti-tubercular drug delivery: an emerging paradigm for improved therapeutic intervention

Nabi

Rehman

Aggarwal

et al. 2020

Drug Deliv. and Transl. Res.

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Tuberculosis (TB) classified as one of the most fatal contagious diseases is of prime concern globally. Mycobacterium tuberculosis is the causative agent that ingresses within the host cells. The approved conventional regimen, though the only viable option available, is unfavorably impacting the quality of life of the affected individual. Despite newer antibiotics gaining light, there is an unending demand for more therapeutic alternatives. Therefore, substantial continuous endeavors are been undertaken to come up with novel strategies to curb the disease, the stepping stone being nanotechnology. This approach is instrumental in overcoming the anomalies associated with conventional therapy owing to their intriguing attributes and leads to optimization of the therapeutic effect to a certain extent. This review focusses on the different types of nanocarrier systems that are being currently explored by the researchers for the delivery of anti-tubercular drugs, the outcomes achieved by them, and their prospects.

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