Alternative Method of Visceral Obesity Assessment in the Diagnostics of Metabolic Syndrome

Веселовская, Н. Г.; Чумакова, Г. А.; Отт, А. В.; Гриценко, О. В.; Шенкова, Н. Н.

doi:10.15829/1560-4071-2014-3-82-86

Cited by 7 publications

(2 citation statements)

References 11 publications

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“…Two groups of patients were identified, patients with EO (Group I) and patients without EO (Group II). EO was defined as an increase in the epicardial adipose tissue (tEAT) of ≥7 mm, which in clinical research is associated with a higher risk of insulin resistance, dyslipidemia, and other metabolic disorders [15]. The mean tEAT was 8.39 (7.0, 9.0) mm in group I and 4.74 (4.0, 6.0) mm in group II (p < 0.001).…”

Section: Clinical and Anamnestic Characteristics Of The Study Patientsmentioning

confidence: 99%

Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity

Чумакова¹,

Гриценко²,

Груздева³

et al. 2021

aging

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Myocardial fibrosis is considered a key pathological process in the development of cardiovascular diseases. In epicardial obesity (EO), the main cause of fibrosis development is lipotoxic myocardial damage. It is important to detect myocardial fibrosis at an early stage, using non-invasive diagnostic methods. According to the results of echocardiography (ECG), 110 men with general obesity were divided into the following two groups: Group I with epicardial fat thickness (tEAT) ≥ 7 mm (n = 70) and Group II with tEAT < 7 mm (n = 40) without diastolic dysfunction. The levels of metabolic factors, pro-inflammatory cytokines, adipokines, and free fatty acids (FFA), profibrotic markers were determined in both groups. In Group I, the level of interleukin (IL)-6, C-reactive protein, and tumor necrosis factor (TNF)-α increased and that of leptin and adiponectin decreased compared with those in Group II. There was an increase in the level of all studied profibrotic factors in Group I. The level of TNF-α and IL-6 showed a positive correlation with the level of leptin and FFA and a negative correlation with the level of adiponectin. We also observed a relationship between the level of collagen, transforming growth factor (TGF)-β, and metalloproteinase (MMP)-3 and EO. Our results showed that confirmed EO correlates with not only disadipocytosis and increased levels of pro-inflammatory cytokines, but also increased levels of profibrotic factors. This suggests that the studied markers of fibrosis may be used to determine preclinical cardiac fibrosis with lipotoxic myocardial damage in patients with EO.

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Section: Clinical and Anamnestic Characteristics Of The Study Patientsmentioning

confidence: 99%

Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity

Чумакова¹,

Гриценко²,

Груздева³

et al. 2021

aging

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“…показано, что тЭЖТ ≥7 мм является более точным неинвазивным марке-ром инсулинорезистентности, нейрогумораль-ных и провоспалительных нарушений, связан-ных с висцеральным ожирением. Авторы счи-тают, что показатель тЭЖТ ≥7 мм можно ис-пользовать как уточняющий критерий висце-рального ожирения [25].…”

Section: рис 2 схема и сонограмма ультразвукового исследования препunclassified

Ultrasound Possibilities in the Diagnosis of Obesity in Pregnant Women

Чабанова¹,

Dorodneva²,

Baklaeva³

2017

Rejr

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Early diagnosis of myocardial fibrosis in patients with epicardial obesity

2021

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It has been proven that about half of patients with heart failure (HF) have a preserved the left ventricle (LV) ejection fraction (EF), which complicates early detection of HF. Currently, there is a search for non-invasive methods for diagnosing myocardial fibrosis at the preclinical heart failure to prevent its progression and the appearance of clinical symptoms.Aim. To study the relationship of LV mechanics with the level of serum myocardial fibrosis markers in patients with epicardial obesity (EO).Material and methods. The study included 110 men with general obesity. Depending on echocardiographic data, the patients were divided into 2 groups: EO (+) with epicardial fat thickness (EFT) ≥7 mm (n=70); EO (-) with EFT <7 mm (n=40). All patients were studied for serum profibrotic markers (MMP-3, collagen I, collagen III, TGF-β, VEGFA, PICP) using enzyme-linked immunosorbent assay. Speckle-tracking echocardiography was used to study LV mechanics (LV twisting, LV twisting rate, time to peak twist, LV untwisting rate, time to peak untwist). The exclusion criteria were the presence of coronary artery disease, hypertension, type 2 diabetes.Results. In the group of patients with EO (+), a significant increase in the level of all studied profibrotic markers was revealed. According to the results of speckletracking echocardiography in the EO (+) group, an increase in the LV untwisting rate to -128,31 (-142,0; -118,0) deg/s-1 (p=0,002) and an increase in the time to peak untwist to 476,44 (510,0; 411,0) ms compared to the EO (-) group (p=0,03). A weak significant effect of EFT on LV untwisting rate was revealed in the EO (+) group (r=0,24; p=0,04). In addition, a significant relationship was found between the LV untwisting rate and markers of myocardial fibrosis: MMP-3 (r=0,21; p=0,04) and type III collagen (r=0,26; p=0,03).Conclusion. Thus, the obtained data suggest that patients with EO have signs of preclinical LV diastolic dysfunction, which are characterized by an increase in LV untwisting rate and level of serum profibrotic factors.

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Alternative Method of Visceral Obesity Assessment in the Diagnostics of Metabolic Syndrome

Cited by 7 publications

References 11 publications

Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity

Analysis of probable lipotoxic damage and myocardial fibrosis in epicardial obesity

Ultrasound Possibilities in the Diagnosis of Obesity in Pregnant Women

Early diagnosis of myocardial fibrosis in patients with epicardial obesity

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