Alternative HPV vaccination schedules in Latin America

Robles, Claudia; Hernández, María de la Luz; Almonte, Maribel

doi:10.21149/9810

Cited by 6 publications

(9 citation statements)

References 38 publications

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“…The HPV vaccination in Mexico began in 2009 [57]. The bivalent vaccine (Cervarix) was implemented with a three-dose schedule (0, 6, and 60 months) [57].…”

Section: Discussionmentioning

confidence: 99%

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Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Oyervides-Muñoz

Pérez-Maya

Sánchez‐Domínguez

et al. 2020

Viruses

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Persistent high-risk human papillomavirus (HR-HPV) infections play a major role in the development of invasive cervical cancer (CC), and screening for such infections is in many countries the primary method of detecting and preventing CC. HPV typing can be used for triage and risk stratification of women with atypical squamous cells of undetermined significance (ASC-US)/low-grade cervical lesions (LSIL), though the current clinical practice in Mexico is to diagnose CC or its preceding conditions mainly via histology and HR-HPV detection. Additional information regarding these HPV infections, such as viral load and co-infecting agents, might also be useful for diagnosing, predicting, and evaluating the possible consequences of the infection and of its prevention by vaccination. The goal of this follow-up hospital case study was to determine if HPV types, multiple HPV infections, and viral loads were associated with infection persistence and the cervical lesion grade. A total of 294 cervical cytology samples drawn from patients with gynecological alterations were used in this study. HPV types were identified by real-time PCR DNA analysis. A subset of HPV-positive patients was reevaluated to identify persistent infections. We identified HPV types 16, 18, and 39 as the most prevalent. One hundred five of the patients (59%) were infected with more than one type of HPV. The types of HPV associated with multiple HPV infections were 16, 18, and 39. In the follow-up samples, 38% of patients had not cleared the initially detected HPV infection, and these were considered persistent. We found here an association between multiple HPV infections and high viral loads with and infection persistence. Our findings suggest there are benefits in ascertaining viral load and multiple HPV infections status of HR-HPV infections for predicting the risk of persistence, a requirement for developing CC. These findings contribute to our understanding of HPV epidemiology and may allow screening programs to better assess the cancer-developing risks associated with individual HR-HPV infections.

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“…The HPV vaccination in Mexico began in 2009 [57]. The bivalent vaccine (Cervarix) was implemented with a three-dose schedule (0, 6, and 60 months) [57].…”

Section: Discussionmentioning

confidence: 99%

“…The HPV vaccination in Mexico began in 2009 [57]. The bivalent vaccine (Cervarix) was implemented with a three-dose schedule (0, 6, and 60 months) [57]. At present, a scenario of universal vaccination coverage against HPV in Mexico is not viable, given the high costs of the vaccine [58].…”

Section: Discussionmentioning

confidence: 99%

Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Oyervides-Muñoz

Pérez-Maya

Sánchez‐Domínguez

et al. 2020

Viruses

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“…Tres vacunas anti-VPH disponen de licencia para su comercialización en el mundo: una bivalente (VPH 16 y 18), una cuadrivalente (los anteriores + VPH 6 y 11) y una nonavalente (los anteriores + VPH 31, 33, 45, 52 y 58). 18,19 La gran heterogeneidad del VPH en México puede impactar en la eficacia de la vacunación como método de prevención primaria. Actualmente, la cobertura de vacunación en México es de 40 %; 20 el objetivo es alcanzar una cobertura nacional superior a 70 %, en el que se incluyan niñas de 12 a 16 años.…”

Section: Figura 2 Distribución De Los Genotipos Del Virus Del Papilom...unclassified

HPV infection profile in cervical lesions

González-Yebra¹,

Mojica-Larrea²,

Alonso³

et al. 2022

GMM

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Introducción: La prevalencia de los diferentes genotipos de virus del papiloma humano (VPH) varía dependiendo de la severidad de la lesión y región geográfica. Objetivo: Identificar infecciones múltiples de VPH en lesiones cervicales de bajo y alto grado en un grupo de mujeres del Bajío mexicano referidas con citología no concluyente. Métodos: Estudio piloto de mujeres referidas de unidades del primer nivel de atención de Guanajuato, México, por citología sugerente de lesión cervical. Los raspados cervicales fueron sujetos a extracción de ADN y genotipificación del VPH mediante microarreglos. Resultados: Se colectaron 100 casos consecutivos y fueron analizados 90; se observó 26 % de positividad a VPH en mujeres sanas y 62 % presentó algún grado de lesión. Los genotipos de VPH más frecuentes fueron 59, 31, 16 y 51. En la mayoría de las muestras se encontró infección múltiple. Conclusiones: Se identificó heterogeneidad de VPH en las muestras de la población estudiada en contraste con los reportes internacionales; además, son comunes las infecciones múltiples en lesiones precursoras y disminuyen en las lesiones de alto grado. Estos datos podrían influir en los actuales programas de vacunación anti-VPH.

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“…Three HPV vaccines have commercialization regulatory approval in the world: a bivalent (HPV 16 and 18), a quadrivalent (the latter + HPV 6 and 11) and a 9-valent vaccine (the latter + HPV 31, 33, 45, 52 and 58). 18,19 HPV high heterogeneity in Mexico may impact vaccination efficacy as a primary prevention method. Currently, vaccination coverage in Mexico is 40%; 20 the goal is to achieve a national coverage higher than 70%, with girls between 12 and 16 years of age being included.…”

Section: Discussionmentioning

confidence: 99%

Perfil de infecciones por VPH en lesiones cervicales

González-Yebra¹,

Mojica-Larrea²,

Alonso³

et al. 2022

GMM

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Introduction: The prevalence of the different genotypes of human papillomavirus (HPV) varies depending on lesion severity and geographic region Objective:To identify multiple HPV infections in low-and high-grade cervical lesions in a group of women from the Mexican Bajío region referred with inconclusive cytology. Methods: Pilot study of women referred from primary care units of Guanajuato, Mexico, with cytology suggestive of cervical lesion. Cervical smears were subjected to DNA extraction and HPV genotyping using microarrays. Results: 100 consecutive cases were collected and 90 were analyzed; HPV positivity was observed in 26% of healthy women, and 62% had some degree of cervical lesion. The most common HPV genotypes were 59, 31, 16 and 51. Multiple infections were found in most samples. Conclusions: HPV heterogeneity was identified in the samples of the study population in contrast to worldwide reports; furthermore, multiple infections are common in precursor lesions and decrease in high-grade lesions. These data could have an impact on current HPV vaccination programs.

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Alternative HPV vaccination schedules in Latin America

Cited by 6 publications

References 38 publications

Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

HPV infection profile in cervical lesions

Perfil de infecciones por VPH en lesiones cervicales

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