Emission characteristics of a turbocharged, intercooled, heavy-duty diesel engine operating on neat gas-toliquids (GTL) and blends of GTL with conventional diesel were investigated and a comparison was made with those of diesel fuel. The results show that nitrogen oxides (NO x ), smoke, and particulate matter (PM) emissions can be decreased when operating on GTL and diesel-GTL blends. Engine emissions decrease with an increase of GTL fraction in the blends. Compared with diesel fuel, an engine operating on GTL can reduce NO x , PM, carbon monoxide (CO), and hydrocarbon (HC) by 23.7%, 27.6%, 16.6% and 12.9% in ECE R49 13-mode procedure, respectively. Engine speed and load have great influences on emissions when operating on diesel-GTL blends and diesel fuel in the turbocharged diesel engine. The study indicates that GTL is a promising alternative fuel for diesel engines to reduce emissions.