Alternative Definitions of Cerebral Aneurysm Morphologic Parameters Have an Impact on Rupture Risk Determination

Kocur, Damian; Przybyłko, Nikodem; Niedbała, Marcin; Rudnik, Adam

doi:10.1016/j.wneu.2019.01.283

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Aneurysm size is one of the most common morphologic parameters; larger aneurysms tend to rupture more easily [6]. The aspect ratio (aneurysm dome / neck width) or bottleneck factor (aneurysm height / neck width) are also frequently referred to as rupture indices [7,8]. Aneurysm morphology is considerably affected by the IA flow and IA embolization.…”

Section: Introductionmentioning

confidence: 99%

In vitro hydrodynamical study on aneurysmal morphology for treating intracranial aneurysms using particle imaging velocimetry

2020

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Section: Introductionmentioning

confidence: 99%

In vitro hydrodynamical study on aneurysmal morphology for treating intracranial aneurysms using particle imaging velocimetry

2020

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“…Previous studies focused only on the “linear” relationship and yielded conflicting results. Twelve studies (sample size ranging from 8 to 425) and two systematic reviews (19 studies, 1553 cases) found a positive correlation between AR and IA rupture ( 23 – 36 ). Eight studies (sample size ranging from 45 to 713) found AR was not associated with ruptured IA ( 17 , 20 , 37 – 42 ).…”

Section: Discussionmentioning

confidence: 99%

U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study

Yin

Zhang

et al. 2021

Front. Neurol.

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Background: Previous studies have analyzed the association of aspect ratio (AR) on the ruptured intracranial aneurysm (IA), but the findings are inconclusive and controversial. Therefore, the study aimed to derive a more detailed estimation of this association between AR and ruptured IA in Chinese IA patients.Methods: The present work was a cross-sectional study. We retrospectively collected 1,588 Chinese patients with a single IA from January 2010 to November 2017. The relationship was examined between AR at diagnosis and ruptured IA. Covariates included data of demographics, morphological parameters, lifestyle habits, clinical features, and comorbidities. Binary logistic regression and two-piecewise linear models were used to analyze independent associations of AR with ruptured IA.Results: The results suggest that the association between AR and IA rupture was U-shaped. In the AR range of 1.08–1.99, the prevalence of IA rupture was 13% lower for each 0.1-unit increment in AR [odds ratio 0.87, 95% confidence interval (CI) 0.80–0.98]. Conversely, for every 0.1-unit increase in AR, the prevalence of IA rupture increased by ~3% (odds ratio 1.03, 95% CI 1.01–1.06) in the AR range of 3.42–4.08.Conclusion: The relationship between AR and ruptured IA was U-shaped, with the negative association at AR of 1.08–1.99 and positive association at AR of 3.42–4.08.

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“…2019; Kocur et al. 2019). A recent meta-analysis revealed that aneurysm size and aspect ratio were the parameters with the strongest correlation with aneurysm rupture (Liang et al.…”

Section: Introductionmentioning

confidence: 99%

“…The outcome of the treatment with FDS depends on numerous parameters such as location (Sunohara et al 2021), aneurysm size or shape (Daou et al 2019) and neck size (Cebral et al 2014;Su et al 2020). These geometrical parameters also play a very important role in predicting aneurysm rupture (Fung et al 2019;Kocur et al 2019). A recent meta-analysis revealed that aneurysm size and aspect ratio were the parameters with the strongest correlation with aneurysm rupture (Liang et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters

Chassagne,

Barbour,

Levitt

et al. 2023

J. Fluid Mech.

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Characterizing the haemodynamics in intracranial aneurysms is of high interest as it impacts aneurysm growth, rupture and treatment, especially with flow-diverting stents (FDS). Flow in these geometries is known to depend on the Dean, Reynolds and Womersley numbers, $De$ , $Re$ , $Wo$ , but is also influenced by geometrical parameters such as the sac shape or the size of the opening. Via particle image velocimetry, this parametric study aimed at evaluating the combined effects of $Re$ , $De$ , $Wo$ and the geometry of the aneurysmal sac on the haemodynamics before and after treatment with FDS. Eight ellipsoidal idealized aneurysm models were created with two curvatures of the parent vessel, two aspect ratios of the sac and two neck sizes. Before treatment, a single counter-rotating vortex, whose strength increases with $Re$ and $De$ , as well as with the neck size and the aspect ratio, was observed in the sac for all but one geometry. After treatment with FDS, four different flow topologies were observed, depending on the geometry: no separation, separation for part of the cycle, two opposing vortices or a single counter-rotating vortex. A linear model with interaction revealed the predominant effect of $De$ and the curvature of the parent vessel on the haemodynamics before and after treatment. This work once more demonstrated the primary role of haemodynamics in the treatment of intracranial aneurysms with FDS. Future work will consider the complexity of patient-specific geometries, and their effects on both the haemodynamics in the sac and the porosity of the FDS.

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Alternative Definitions of Cerebral Aneurysm Morphologic Parameters Have an Impact on Rupture Risk Determination

Cited by 8 publications

References 27 publications

In vitro hydrodynamical study on aneurysmal morphology for treating intracranial aneurysms using particle imaging velocimetry

In vitro hydrodynamical study on aneurysmal morphology for treating intracranial aneurysms using particle imaging velocimetry

U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study

Fluid dynamics in intracranial aneurysms treated with flow-diverting stents: effect of multiple geometrical parameters

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