U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study

Abstract

Background: Previous studies have analyzed the association of aspect ratio (AR) on the ruptured intracranial aneurysm (IA), but the findings are inconclusive and controversial. Therefore, the study aimed to derive a more detailed estimation of this association between AR and ruptured IA in Chinese IA patients.Methods: The present work was a cross-sectional study. We retrospectively collected 1,588 Chinese patients with a single IA from January 2010 to November 2017. The relationship was examined between AR at diagnosis and ruptured IA. Covariates included data of demographics, morphological parameters, lifestyle habits, clinical features, and comorbidities. Binary logistic regression and two-piecewise linear models were used to analyze independent associations of AR with ruptured IA.Results: The results suggest that the association between AR and IA rupture was U-shaped. In the AR range of 1.08–1.99, the prevalence of IA rupture was 13% lower for each 0.1-unit increment in AR [odds ratio 0.87, 95% confidence interval (CI) 0.80–0.98]. Conversely, for every 0.1-unit increase in AR, the prevalence of IA rupture increased by ~3% (odds ratio 1.03, 95% CI 1.01–1.06) in the AR range of 3.42–4.08.Conclusion: The relationship between AR and ruptured IA was U-shaped, with the negative association at AR of 1.08–1.99 and positive association at AR of 3.42–4.08.

Different Hemodynamic Characteristics and Resulting in Different Risks of Rupture Between Wide-Neck and Narrow-Neck Aneurysms

“…By comparing the results of most studies, we found that the mean AR value of ruptured aneurysms was mostly about 1.6, all in the range of wide-neck ( 33 , 36 ). Yin et al latest research found that non-linearity relationship of AR correlation to IA rupture, in the AR range of 1.08–1.99, the prevalence of IA rupture was lower for increment in AR, the prevalence of IA rupture increased in the AR range of 3.42–4.08, no association between AR and the prevalence of IA rupture in the AR range of 1.99–3.42 ( 37 ). In clinical practice, the AR of narrow-necked aneurysms with size <10 mm is rarely >3.42.…”

Assessing the risk of intracranial aneurysm rupture using computational fluid dynamics: a pilot study

“…Although our research results differ from previous studies because we analyzed only three aneurysms in two cases, our results cannot deny the predictive value of AR for the risk of IA rupture. Besides, Yin et al (31) believe that there is a U-shaped correlation between AR and the risk of aneurysm rupture, with a negative correlation range of 1.08 < AR ≤ 1.99 and a positive correlation range of 3.42 < AR ≤ 4.08. Further research with a larger sample size is needed to validate the ability of AI to assess the risk of aneurysm rupture.…”