“…188 Although scarce, there is promising evidence that treatments based on existing therapies (CBT, parental training, and pharmacotherapy), adapted to atrisk populations, i.e., highly symptomatic children, but still not meeting criteria for the diagnosis of anxiety disorders, or children with first-degree relatives diagnosed with anxiety disorders, result in preventing and reducing the severity of these disorders. 189 This is a general overview about pediatric anxiety disorders. More specific and comprehensive reviews about the following topics can be found in the literature: prevalence, 15,[18][19][20] behavioral inhibition, [190][191][192] behavioral genetics, 48,52 genetics, 55,56,193,194 gene vs. environment interplay, 52,70 pathophysiology, 31,71 neural substrates, 71 normal development of fears, 195 psychopharmacological treatment, [196][197][198] and CBT.…”