Altered Viscosity of Nasal Secretions in Postnasal Drip

Bucher, Sarina; Schmid‐Grendelmeier, Peter; Soyka, Michael

doi:10.1016/j.chest.2019.04.133

Cited by 9 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 This may be because patients with PND tend to have viscid secretions containing inflammatory cells and neuropeptides that cause inflammation and dysesthesia of the nasopharynx. 6,7 This may also explain the poor specificity of posterior nasal cavity secretions to predict PND. Redness of the nasopharynx was found to be higher among patients with rhinitis only compared with the PND group.…”

Section: Discussionmentioning

confidence: 99%

The Nasal Endoscopic Features of Postnasal Drip: A Cross Sectional Study

Tarmizi

Hamizan

et al. 2023

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction Patients with chronic rhinitis suffer from postnasal drip (PND) but this symptom is not well addressed. Nasal endoscopy may aid in identifying PND. Well described endoscopic features of PND are presence of secretions in the posterior nasal cavity, diffuse erythema, and hemorrhagic spots in the nasopharynx, but these have not been formally studied. Objectives The present study aims to assess the association of nasal endoscopic features with PND among rhinitis patients. This will guide clinicians to interpret the nasal endoscopic findings appropriately. Methods Adults (≥ 18 years old) with chronic rhinitis were consecutively recruited at an Otorhinolaryngology outpatient clinic in a tertiary referral center. The patients were grouped into either “Rhinitis with PND” or “Rhinitis only.” The endoscopic features of PND were scored as: Secretions in the posterior nasal cavity (yes/no), erythema in the nasopharynx (none, roof only, diffuse), hemorrhagic spots (yes/no), then were compared between groups. Results There were 98 patients included (age 32.32 ± 11.33 years old, 61.2% female, 61.2% PND). Presence of secretions in the posterior nasal cavity was associated with PND (“Rhinitis with PND” versus “Rhinitis only,” 78.3 versus 55.3; p = 0.02; Odds ratio: 2.81; 95% confidence interval [CI]: 1.08–7.32). Diffuse erythema of the nasopharynx was more frequent in “rhinitis only” compared with those with PND (76.3 versus 53.3%; p = 0.02). Hemorrhagic spots were equally present in both groups (11.7 versus 18.4%; p = 0.35). Conclusion Presence of secretions in the posterior nasal cavity may indicate bothersome PND among patients with rhinitis. Diffuse erythema of the nasopharynx and hemorrhagic spots are a nonspecific sign of inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

The Nasal Endoscopic Features of Postnasal Drip: A Cross Sectional Study

Tarmizi

Hamizan

et al. 2023

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…All proteins identified in healthy mucus (15) and mucosa (37) samples were also present in CRS mucus and mucosa samples, respectively.…”

Section: Common Proteome In Crs and Healthymentioning

confidence: 96%

“…The overproduction of viscous nasal mucus is commonly reported amongst CRS patients manifested as rhinorrhoea and postnasal drip. This tenacious mucus adversely affects ciliary function, leading to stasis that may result in a nidus for bacterial growth (13)(14)(15) .…”

Section: Introductionmentioning

confidence: 99%

Scoping review of chronic rhinosinusitis proteomics

Kao¹,

Bassiouni²,

Ramezanpour³

et al. 2020

Rhin

View full text Add to dashboard Cite

Background: Progressive advances in proteomic technology has improved our understanding of the chronic rhinosinusitis (CRS) pathogenesis and endotypes. This scoping review aims to present a comprehensive and descriptive analysis of nasal mucosa and mucus proteome of CRS patients.Methodology: Studies investigating the proteome of nasal mucosa and mucus from healthy and CRS patients via mass spectrometry were included. Critical appraisal of methodological quality was conducted with extraction of protein lists. Gene set enrichment analysis (GSEA) was performed on studies including CRS patients.Results: 2962 proteins were identified in the 21 studies included in this review. Eleven studies investigated the nasal mucus proteome and ten studies investigated the nasal mucosa proteome. Studies demonstrated heterogeneity in patients, sampling and mass spectrometry methodology. Samples from CRS patients suggested a trend in enrichment of immune system and programmed cell death pathways. Increased expression of proteins involved in cellular components including the cytoskeleton and adherens junctions was also present in CRS.Conclusions: Alterations in the healthy sinonasal proteome may lead to the increased immunological, metabolic and tissue remodeling processes observed in CRS. However, it is difficult to draw significant conclusions from the GSEA due to the heterogeneity present in the limited literature available. These findings allow us to direct further research to better understand CRS pathogenesis and its endotypes.

show abstract

“…Nasal mucus comprises 95% of water, 2.5% of glycoproteins, 1%–2% of electrolytes, and several kinds of proteins including lysozyme, lactoferrin, and complement. [ 21 ] In the nasal microenvironment, the concentration of lysozyme is about 30 µg mL −1 . [ 6a ] Under acidic conditions, lysozyme is a kind of bacterial enzyme that kills certain microbes, however, the lysozyme is inactive under alkaline conditions, resulting in microbial infection of the nasal mucosa.…”

Section: Nasal Microenvironmentmentioning

confidence: 99%

Hydrogel‐Based Intranasal Delivery Systems for The Treatment of Allergic Rhinitis

Fan

Jia

Huang

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

Allergic rhinitis, as the most common type of rhinitis, has become a global health problem. At present, oral/intranasal administration of H1‐antihistamines and corticosteroids is considered to be the main therapeutic method for allergic rhinitis. However, the local bioavailability of the drug is low due to the systemic effect of drugs and nasal mucociliary clearance. More recently, a hydrogel‐based intranasal delivery system (HIDS) is proposed and gradually developed as an emerging strategy for allergic rhinitis treatment by extending the residence time of drugs in a controlled manner. This review aims to highlight the advances in HIDS for allergic rhinitis treatment. The designs and therapeutic effect of the existing HIDS in the nasal microenvironment are described in detail. This review also provides a perspective on the future opportunities and developments of HIDS. Despite its nascent status, the future clinical and translational applications of HIDS can have a transformative impact on improving the treatment of chronic inflammation in the nasal cavity.

show abstract

Altered Viscosity of Nasal Secretions in Postnasal Drip

Cited by 9 publications

References 21 publications

The Nasal Endoscopic Features of Postnasal Drip: A Cross Sectional Study

The Nasal Endoscopic Features of Postnasal Drip: A Cross Sectional Study

Scoping review of chronic rhinosinusitis proteomics

Hydrogel‐Based Intranasal Delivery Systems for The Treatment of Allergic Rhinitis

Contact Info

Product

Resources

About