Altered topological blueprint of trabecular bone associates with skeletal pathology in humans

Reznikov, Natalie; Alsheghri, Ammar; Piché, Nicolas; Gendron, Mathieu; Desrosiers, Catherine; Морозова, И. М.; Siles, Juan Manuel Sánchez; González-Quevedo, David; Tamimi, Iskandar; Song, Jun; Tamimi, Faleh

doi:10.1016/j.bonr.2020.100264

Cited by 15 publications

(17 citation statements)

References 58 publications

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“…Reznikov et al (2020) found that trabecular 'blueprints' (without considering thickness) differed in OA, and osteoporotic human femora differed from those of normal subjects, with a lower resistance tocompressive stress, higher von Mises stress and more shear-dominant elements (based on FE analysis of skeletonised VOIs). Discovery of the three exciting biomarkers (trabecular anisotropy, cortical volume F I G U R E 6 Trabecular BV/TV depends on strain, and strains show disparate ageing phenotypes.…”

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confidence: 99%

3D profiling of mouse epiphyses across ages reveals new potential imaging biomarkers of early spontaneous osteoarthritis

et al. 2023

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Worldwide research groups and funding bodies have highlighted the need for imaging biomarkers to predict osteoarthritis (OA) progression and treatment effectiveness. Changes in trabecular architecture, which can be detected with non-destructive high-resolution CT imaging, may reveal OA progression before apparent articular surface damage. Here, we analysed the tibial epiphyses of STR/Ort (OA-prone) and CBA (healthy, parental control) mice at different ages to characterise the effects of mouse age and strain on multiple bony parameters. We isolated epiphyseal components using a semi-automated method, and measured the total epiphyseal volume; cortical bone, trabecular bone and marrow space volumes; mean trabecular and cortical bone thicknesses; trabecular volume relative to cortical volume; trabecular volume relative to epiphyseal interior (trabecular BV/TV); and the trabecular degree of anisotropy.Using two-way ANOVA (significance level ≤0.05), we confirmed that all of these parameters change significantly with age, and that the two strains were significantly different in cortical and trabecular bone volumes, and trabecular degree of anisotropy. STR/Ort mice had higher cortical and trabecular volumes and a lower degree of

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confidence: 99%

3D profiling of mouse epiphyses across ages reveals new potential imaging biomarkers of early spontaneous osteoarthritis

et al. 2023

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“…The MIL technique calculates the fabric tensor using the average distance between collinear points that lie on the periphery of segmented struts (Lavg), where varying angular orientations (ω) and a defined number of lines (m) are used to assign a final anisotropy value according to some scalar value as outlined in Equation 1 [40,41].…”

Section: Strut Analysismentioning

confidence: 99%

Selective Voronoi tessellation as a method to design anisotropic and biomimetic implants

Deering

Dowling

DiCecco

et al. 2021

Journal of the Mechanical Behavior of Biomedical Materials

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“…Before 3D image rendering, several steps, including 2D/3D image de-noising, image segmentation, and contrast enhancing, are necessary to produce high-quality visualization of a cellular structure [24]. Using tomographic reconstruction, previous studies have identified skeletonization as an effective way of encoding topological motifs of porous architecture for quantitative investigation of its physical or mechanical properties [25,26]. In these studies, most processes of skeletonization rely on plugins to commercial tomography analysis software [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the topological motifs of the cellular structure of the tri-spine horseshoe crab (Tachypleus tridentatus) and its associated mechanical properties

Ma¹,

Guo²,

Shen³

et al. 2022

Bioinspir. Biomim.

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Topological motifs in pore architecture can profoundly influence the structural properties of that architecture, such as its mass, porosity, modulus, strength, and surface permeability. Taking the irregular cellular structure of the tri-spine horseshoe crab as a research model, we present a new approach to the quantitative description and analysis of structure–property–function relationships. We employ a robust skeletonization method to construct a curve-skeleton that relies on high-resolution 3D tomographic data. The topological motifs and mechanical properties of the long-range cellular structure were investigated using the Grasshopper plugin and uniaxial compression test to identify the variation gradient. Finite element analysis was conducted for the sub-volumes to obtain the variation in effective modulus along the three principal directions. The results show that the branch length and node distribution density varied from the tip to the base of the sharp corner. These node types formed a low-connectivity network, in which the node types 3-N and 4-N tended to follow the motifs of ideal planar triangle and tetrahedral configurations, respectively, with the highest proportion of inter-branch angles in the angle ranges of 115–120° and 105–110°. In addition, mapping the mechanical gradients to topological properties indicated that narrower profiles with a given branch length gradient, preferred branch orientation, and network connectedness degree are the main factors that affect the mechanical properties. These factors suggest significant potential for designing a controllable, irregularly cellular structure in terms of both morphology and function.

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Altered topological blueprint of trabecular bone associates with skeletal pathology in humans

Cited by 15 publications

References 58 publications

3D profiling of mouse epiphyses across ages reveals new potential imaging biomarkers of early spontaneous osteoarthritis

3D profiling of mouse epiphyses across ages reveals new potential imaging biomarkers of early spontaneous osteoarthritis

Selective Voronoi tessellation as a method to design anisotropic and biomimetic implants

Analysis of the topological motifs of the cellular structure of the tri-spine horseshoe crab (Tachypleus tridentatus) and its associated mechanical properties

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