Altered spontaneous brain activity patterns in patients with unilateral acute open globe injury using amplitude of low-frequency fluctuation: a functional magnetic resonance imaging study

Abstract

ObjectiveThe aim of this study was to evaluate altered spontaneous brain activities in patients with unilateral acute open globe injury (OGI) using amplitude of low-frequency fluctuation (ALFF) method and its relationship with their clinical manifestations.Patients and methodsA total of 18 patients with acute OGI (16 males and two females) and 18 healthy controls (HCs, 16 males and two females) closely matched in age, sex, and education were recruited in this study. The ALFF method was used to evaluate the altered spontaneous brain activities. The relationships between the mean ALFF signal values of different brain regions and the clinical features were evaluated by correlation analysis. Acute OGI patients were distinguished from HCs by receiver operating characteristic curve.ResultsCompared with HCs, acute OGI patients had significantly higher ALFF values in the left cuneus, left middle cingulum cortex, and bilateral precuneus. Furthermore, the age of OGI patients showed a negative correlation with the ALFF signal value of the left middle cingulum cortex (r=−0.557, P=0.016) and a negative correlation with the mean ALFF signal value of the bilateral precuneus (r=−0.746, P<0.001). The ALFF signal value of the bilateral precuneus was negatively correlated with the duration of OGI (r=−0.493, P=0.038) and positively correlated with the vision acuity of the injured eye (r=0.583, P=0.011).ConclusionAcute OGI mainly induces dysfunction in the left cuneus, left middle cingulum cortex, and bilateral precuneus, which may reflect the underlying pathologic mechanisms of abnormal brain activities in OGI patients.

Altered spontaneous brain activity patterns in patients with retinal vein occlusion indicated by the amplitude of low‑frequency fluctuation: A functional magnetic resonance imaging study

“…The reduction of ALFF represents the decrease of the BOLD signal in this brain region. To date, ALFF has been applied in ophthalmology research on conditions including glaucoma (14,15), amblyopia (16), strabismus (17), high myopia (18), optic neuritis (19), eye trauma (20), blindness (21), retinal detachment (22), diabetic retinal diseases (23) and acute eye pain (24). To the best of our knowledge, the present study is the first to explore ALFF in different brain regions of patients with RVO.…”

Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity

“…In our study, we also found that the HADS scale scores presented a positive correlation between VMHC values and the cingulum ant (r = 0.907; P < 0.001). The cingulum gyrus belongs to the classic circuits of the limbic system, which is closely related to memory and emotion [ 56 ],potentially indicating that the limbic system is affected in patients with SA [ 57 ]. Strabismus amblyopia influences the visual acuity, deviation of the eye position as well as eye movements and causes aesthetic problems.…”

<p>Resting-state functional magnetic resonance imaging (fMRI) and functional connectivity density mapping in patients with corneal ulcer</p>

“…For example, Myung et al41 showed that patients with adjustment disorder, also had a significant reduction in gray matter volume in the right medial frontal gyrus. Moreover, Tan et al12 demonstrated that the amplitude of low-frequency fluctuation (ALFF) signal values in the bilateral MFG were lower in patients with strabismus, which might indicate alterations in the local synchronization of spontaneous brain activities. In the current study, we found that CU patients had reduced IFCD values in the left MFG.…”

“…This technique has a number of advantages, including precise positioning, the lack of radioactive injury, and the ability to combine functional and anatomic imaging. Thus far, resting-state fMRI has been successfully applied to investigate neurological conditions in certain ocular diseases, such as optic neuritis,10 primary angle-closure glaucoma11 and unilateral acute open globe injury 12…”