Altered spontaneous brain activity pattern in patients with late monocular blindness in middle-age using amplitude of low-frequency fluctuation: a resting-state functional MRI study

Li, Qing; Huang, Xin; Ye, Lei; Wei, Rong; Zhang, Ying; Zhong, Yuan; Jiang, Nan; Shao, Yi

doi:10.2147/cia.s117292

Cited by 37 publications

(27 citation statements)

References 42 publications

(41 reference statements)

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“…Moreover, The V1 is the core part of the visual pathways [ 21 ]. In our previous study, we demonstrated that the MB showed decreased amplitude of low-frequency fluctuation in right cuneus [ 22 ]. Besides, A recent research exhibited that the MB patients showed lower gray matter volume in the bilateral superior lateral occipital cortices compared with health controls [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative study of interhemispheric functional connectivity in left eye monocular blindness versus right eye monocular blindness: a resting-state functional MRI study

et al. 2018

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ObjectiveIn the present study, we investigated the brain interhemispheric functional connectivity changes in left eye MB versus right eye MB patients by voxel-mirrored homotopic connectivity (VMHC) methods.MethodsA total of 31 patients with MB (15 with left eye MB and 16 with right eye MB), and 31 healthy controls (HCs) closely matched for age were recruited. All subjects underwent functional magnetic resonance imaging (fMRI) examinations. The VMHC method was used to evaluate directly functional interactions between the hemispheres. A one-way ANOVA was performed to determine the regions in which the VMHC differs between the three groups. Patients with MB were distinguished from HCs by a receiver operating characteristic (ROC) curve. The relationships between the mean VMHC signal values in many brain regions and clinical features in MB patients were calculated by pearson correlation analysis.ResultsCompared with HCs, MB patients had significantly decreased VMHC values in the cuneus/calcarine/lingual gyrus. Furthermore, left eye MB showed decreased VMHC values in the cuneus/calcarine/lingual gyrus and showed increased VMHC values in the insula and middle frontal gyrus compared with HC. In addition, right eye MB showed decreased VMHC values in the cuneus/calcarine/lingual gyrus, primary motor cortex (M1)/primary somatosensory cortex (S1) and superior parietal lobule.ConclusionMB subjects showed abnormal brain interhemispheric functional connectivity in visual pathways. Furthermore, different patterns of brain interhemispheric functional connectivity occurred in the left eye and right eye MB. These VMHC values provide much useful information to explain the neural mechanism changes in MB.

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Section: Discussionmentioning

confidence: 99%

Comparative study of interhemispheric functional connectivity in left eye monocular blindness versus right eye monocular blindness: a resting-state functional MRI study

et al. 2018

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“…In addition, patients with blindness have shown enhanced SMG functional connectivity (Heine et al, 2015). Li et al (2016) found that patients with MB have elevated SMG amplitude of low-frequency fluctuation (ALFF) values on the left side, and MB was unable to activate the SMG. Therefore, we speculated that the brain coding function of speech coding and processing is a compensatory mechanism for the loss of visual acuity in patients with MB.…”

Section: Ta B L E 2 Gmv Differences Between Mb and Nc Groupsmentioning

confidence: 99%

Central network changes in patients with advanced monocular blindness: A voxel‐based morphometric study

Shi

Tang

et al. 2019

Brain and Behavior

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Objective To study the changes in gray matter volume (GMV) in patients with advanced monocular blindness (MB) using voxel‐based morphometry (VBM). Methods Thirty‐one patients with advanced MB (25 males and six females) and 31 normal controls (25 males and six females) were enrolled. The t test was applied to determine the differences in GMV, white matter volume (WMV), and volume of cerebrospinal fluid in different regions of the brain. The local characteristics of spontaneous concentrations of brain tissue were evaluated by the VBM method. The effects of blindness duration on differences in the GMV were evaluated by correlation and regression analyses. Results Compared with the control group, the GMV was decreased in the upper right margin, bilateral insular cortex, right cingulate gyrus, left occipital gyrus, and right suboccipital lobe, and negatively correlated with blindness duration in the upper right posterior margin, bilateral insular cortex, and right cingulate cortex. Conclusions We found that patients with MB showed abnormal WMV and GMV, as evidenced by local changes in the brain. In addition, reduced GMV in specific parts of the brain was associated with the duration of blindness, which may indicate neuropathological mechanisms of visual loss in patients with MB.

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“… 11 , 12 In our previous studies, the ALFF method was successfully applied to the investigation of spontaneous brain activities in various diseases such as glaucoma and blindness. 13 , 14 Thus, the ALFF method was proven to be a reliable and effective resting-state fMRI technique.…”

Section: Introductionmentioning

confidence: 99%

Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study

Pan¹,

Li²,

Bao³

et al. 2018

NDT

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ObjectiveMany previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic brain activity changes in acute eye pain (EP) patients remain unknown. Using the amplitude of low-frequency fluctuation (ALFF) method, this study aimed to evaluate the spontaneous brain activity alterations and their relationships with clinical features in acute EP patients.Participants and methodsA total of 20 patients with EP (15 males and 5 females) and 20 healthy controls (HCs; 15 males and 5 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was applied to assess spontaneous brain activity changes. The ALFF values of the EP patients were distinguished from those of the HCs using a receiver operating characteristic curve. Pearson’s correlation analysis was used to investigate the relationships between the mean ALFF signal values from many brain regions and the clinical features in EP patients.ResultsCompared with the HCs, acute EP patients had significantly lower ALFF in the left and right precentral/postcentral gyrus and left precuneus. In contrast, acute EP patients showed higher ALFF values in the right and left parahippocampal gyri and left caudate. However, no relationship was observed between the mean ALFF signal values from the different areas and clinical manifestations in the acute EP patients.ConclusionWe demonstrated that acute EP patients showed abnormal intrinsic brain activities in the precentral/postcentral gyrus and limbic system, which might provide useful information for explaining neural mechanisms in EP patients.

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Altered spontaneous brain activity pattern in patients with late monocular blindness in middle-age using amplitude of low-frequency fluctuation: a resting-state functional MRI study

Cited by 37 publications

References 42 publications

Comparative study of interhemispheric functional connectivity in left eye monocular blindness versus right eye monocular blindness: a resting-state functional MRI study

Comparative study of interhemispheric functional connectivity in left eye monocular blindness versus right eye monocular blindness: a resting-state functional MRI study

Central network changes in patients with advanced monocular blindness: A voxel‐based morphometric study

Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study

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