Altered serum and salivary C-reactive protein levels in patients with oral premalignant lesions and oral squamous cell carcinoma

Metgud, Rashmi; Bajaj, Saumya

doi:10.3109/10520295.2015.1077393

Cited by 23 publications

(16 citation statements)

References 28 publications

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“…The mean CRP level was 5.59±9.86 mg/l in group II and 31.72±31.01 mg/l in group III; the difference between the two groups was statistically significant (P<0.001). These results were similar to the findings of a study conducted by Metgud and Bajaj [22] who revealed that mean CRP levels were higher in patients with premalignant oral lesions compared to the controls. CRP levels in OSCC patients were elevated and were associated with advanced tumor stages [22].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study

Vankadara¹,

Padmaja²,

Balmuri³

et al. 2019

JDT

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Objectives: The aim was to evaluate and compare pretreatment serum C-reactive protein (CRP) levels in patients with oral premalignancies and malignancies with that in healthy controls. Materials and Methods: The study sample consisted of 90 patients of both genders. The subjects were divided into three groups. Group I comprised 30 healthy controls, while group II included 30 patients with potential oral malignancies including leukoplakia, oral submucous fibrosis (OSMF), and oral lichen planus (OLP), and group III included 30 squamous cell carcinoma (SCC) patients confirmed by histopathological examination. All samples were subjected to CRP analysis. Serum CRP levels were quantitatively determined using the automated immunoturbidimetric method. Results: In group I, CRP levels were ranging from 0.1 to 18.3 mg/l with the mean ± standard deviation (SD) CRP level of 3.88±4.50 mg/l. In group II, CRP levels were ranging from 0.8 to 53.9 mg/l with the mean ± SD CRP level of 5.59±9.86 mg/l. In group III, CRP levels were ranging from 3.3 to 96 mg/l with the mean ± SD CRP level of 31.72±31.01 mg/l. Conclusions: According to the results, prediagnostic concentrations of CRP are associated with subsequent development of oral cancer and suggest that plasma CRP level is a potential marker of increased risk of cancer

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Section: Discussionsupporting

confidence: 92%

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study

Vankadara¹,

Padmaja²,

Balmuri³

et al. 2019

JDT

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“…CRP levels showed a graded increase according to the severity of the tumour. They suggested that CRP could be regarded as a prognosis marker in OSCC [ 53 ]. Khandavilli et al highlighted that the elevated level of preoperative CRP is an unfavourable prognostic indicator [ 54 ].…”

Section: Markers Of Inflammation In Osccmentioning

confidence: 99%

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Tampa

Mitran

et al. 2018

Journal of Immunology Research

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Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.

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“…Some studies have reported an increase in CRP levels in patients with OSCC and have shown high CRP levels in OSCC patients linked to the advanced tumor stages (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Salivary Lactate Dehydrogenase, C-Reactive Protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma

et al. 2021

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Background: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and oral lichen planus (OLP) is considered a premalignant disease. Objectives: This study aims at comparing the salivary levels of lactate dehydrogenase (LDH), C-reactive protein (CRP), and cancer antigen 125 (CA125) among cases with OSCC, OLP, and healthy persons. Methods: In this case-control study, salivary markers were evaluated in 55 cases (15 patients with OSCC, 20 patients with OLP, and 20 healthy persons); non-stimulated saliva samples were collected from the patients and saliva markers were measured by the enzyme-linked immunosorbent assay (ELISA) method. The data were analyzed, using SPSS 21 software and ANOVA test and P < 0.05 was regarded as significant. Results: Salivary LDH and CA125 levels were significantly higher in OSCC and OLP patients compared to the control group (P < 0.05). Salivary CRP levels were significantly higher in OSCC patients compared to OLP patients (P < 0.05). Besides, salivary CRP levels were higher in OLP subjects than in the control group, but the difference was not significant (P = 0.56). Conclusions: The identification of the salivary LDH, CA125, and CRP may provide a suitable non-invasive predictive tool for malignant changes. However, its use in clinical practice needs further research.

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Altered serum and salivary C-reactive protein levels in patients with oral premalignant lesions and oral squamous cell carcinoma

Cited by 23 publications

References 28 publications

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study

Evaluation of Serum C-Reactive Protein Levels in Oral Premalignancies and Malignancies: A Comparative Study

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Salivary Lactate Dehydrogenase, C-Reactive Protein, and Cancer Antigen 125 Levels in Patients with Oral Lichen Planus and Oral Squamous Cell Carcinoma

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