Altered renal immune complexes deposition in female BWF1 lupus mice following Plasmodium chabaudi infection

Abstract

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that has a mysterious relationship with malaria infection. The current study was designated to compare between the effect of the live and the gamma irradiated Plasmodium chabaudi infection on BWF1 lupus murine model. A total of 30 female BWF1 mice were randomly divided into three groups (10 mice/group) as follows: group (I) lupus group (lupus non infected); group (II) live malaria infected group (lupus + live malaria infection); and group (III) irradiated malaria-infected group (lupus + gamma irradiated malaria infection). Live P. chabaudi infection was accompanied with a decrease in survival rate and food consumption in comparison to the control group of mice while gamma irradiated P. chabaudi -infection was unable to do this effect. Additionally, live P. chabaudi infection was accompanied with an increased level of proteinuria and increased rate of immune complexes deposition in kidney. Moreover, infection with live, but not gamma-irradiated P. chabaudi was accompanied with an increase in nitric oxide (NO), hydrogen peroxide (H2O2), and malondialdehyde (MDA) levels in plasma of lupus mice. The levels of both total cholesterol and triglycerides in plasma of lupus mice after live P. chabaudi infection were obviously decreased in comparison to the control group. On the other hand, gamma-irradiated P. chabaudi infection resembled the control group. Our data revealed that infection of lupus mice with live but not gamma-irradiated P. chabaudi has several histological and biochemical effects.

Increased total antioxidant capacity in renal tissue of female BWF1 mice infected with Plasmodium chabaudi

“…This is in agree with the results obtained by Al-Quraishy et al (2013) which clarified a partial improvement in the lupus-associated renal pathology after live P. chabaudi infection in BWF1 lupus mice. On the contrary, gamma irradiated P. chabaudi -infected group has shown a slight non-significant decreased level of glucose in urine in comparison to the control and this effect of gamma irradiation was elucidated before (Abdel-Maksoud et al, 2016).…”