Altered ratios and different subcellular distribution of type I and type II cAMP‐dependent protein kinases in several thyroidal pathological tissues

Inhibition of growth of PY815 mouse mastocytoma cells in vitro by N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) was accompanied by increases in intracellular cyclic AMP and histamine and minor changes in cytosolic cyclic AMP-dependent histone kinase activity. However, DEAE-cellulose chromatography revealed substantial changes in the relative proportions of the principal cyclic AMP-dependent protein kinases and in free cyclic AMP-binding protein after DB cyclic AMP treatment. The activity of cytosolic cyclic AMP-dependent protein kinase type I (PKI) decreased relative to cyclic AMP-dependent protein kinase type II (PKII) and there was an increase in a cytosol cyclic AMP-binding protein with little associated protein kinase activity. The relative changes in activity of PKI, PKII and cyclic AMP binding protein after DB cyclic AMP treatment may reflect events important in the regulation of growth and differentiation of mast cells.

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Changes in cyclic AMP-dependent protein kinases during inhibition of mastocytoma cell growth by dibutyryl cyclic AMP

Evans

Smart

Airey

et al. 1982

Mol Cell Biochem

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Properties of the cyclic AMP-dependent protein kinases in mouse mastocytoma cells

Smart

Ralph

1983

Mol Cell Biochem

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The properties of type I and type II protein kinases in PY815 mouse mastocytoma cells were shown to change following growth inhibition by prostaglandin E1 and 3-isobutyl-1-methylxanthine. These changes included a large reduction in type I protein kinase consistent with a role for this isoenzyme as a positive effector of growth, a decrease in free cyclic AMP binding protein and an increase in type II protein kinase. Some properties of the fully activated isoenzymes are presented that may be important in determining their activity in vivo.

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A fresh look at an old thyroid disease: euthyroid and hyperthyroid nodular goiter

Studer

1982

J Endocrinol Invest

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Altered ratios and different subcellular distribution of type I and type II cAMP‐dependent protein kinases in several thyroidal pathological tissues

Cited by 9 publications

References 31 publications

Changes in cyclic AMP-dependent protein kinases during inhibition of mastocytoma cell growth by dibutyryl cyclic AMP

Changes in cyclic AMP-dependent protein kinases during inhibition of mastocytoma cell growth by dibutyryl cyclic AMP

Properties of the cyclic AMP-dependent protein kinases in mouse mastocytoma cells

A fresh look at an old thyroid disease: euthyroid and hyperthyroid nodular goiter

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