Altered Proportion of T<sub>μ</sub> and T<sub>γ</sub>‐Cell Subpopulations in Patients with Hodgkin's Disease

Romagnani, Sergio; Maggi, Enrico; Biagiotti, R; Giudizi, Maria Grazia; Amadori, Alberto; Ricci, M

doi:10.1111/j.1365-3083.1978.tb00485.x

Cited by 38 publications

(12 citation statements)

References 11 publications

(10 reference statements)

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“…Our results would appear to be at variance with an earlier study (Romagnani et al, 1978) which showed an imbalance of subsets of peripheral-blood T-cells subsets in HD patients. Such cells identified as Er+ cells expressing receptors for either IgM(TIi) or IgG (Ty), have been described by others (Moretta et al, 1977) as subserving "helper"/"inducer" and "suppressor"/" cytotoxic" functions respectively.…”

Section: T Lymphocytescontrasting

confidence: 56%

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

Dorreen¹,

Habeshaw²,

Wrigley³

et al. 1982

Br J Cancer

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Summary.-Mononuclear-cell suspensions of lymph nodes, spleen and blood from 24 patients with active Hodgkin's disease (HD) were studied for possible imbalance of T and B lymphocytes, and T-lymphocyte subsets, using monospecific anti-T antibodies and other reagents. A profile showing T-cell predominance was demonstrated ln lymph nodes and blood, with total T-cells ranging from 50-70% of the cell count. As defined by monoclonal antibodies, 70-85% of the latter comprised the "inducer" subclass, the remainder being "suppressor" cells. There were no essential differences between histologically involved and uninvolved lymph nodes from HD patients, though total T-cell proportions were lower in "normal lymph node" controls. The profiles of spleens electively removed, as part of pre-treatment staging procedures, showed reduced total T-cell numbers, whether these were involved with HD or not. These differences are accounted for principally by fewer T "inducer" cells (24%, in spleen, v. 54% in involved lymph nodes and 47% in "normal" control nodes).Possible explanations for these findings are discussed. Our results demonstrate similar profiles in histologically diseased and normal tissue, rather than any clear imbalance of T-cell proportions which might explain the profound disturbances of T-cell function frequently demonstrated in vivo and in vitro.

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Section: T Lymphocytescontrasting

confidence: 56%

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

Dorreen¹,

Habeshaw²,

Wrigley³

et al. 1982

Br J Cancer

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“…2). The effect of B cells on the response to PPD observed in this study was, however, much less striking than that reported by Blomgren [6j and Romagnani et a1 [7], as we found them to be only minimally involved in the response to PPD. On the other hand, our results disagree with those reported previously by others…”

Section: Discussioncontrasting

confidence: 78%

Role of adherent T cells and of B cells in the immune response to purified protein derivative of tuberculin

et al. 1979

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The role of monocytes, B cells, and adherent and nonadherent T cells in the response of purified protein derivative of tuberculin (PPD) as measured by [3H]thymidine uptake in vitro has been explored. The response to PPD was found to be highly dependent on monocytes, to approximately the same extent as previously found for the responses to concanavalin A (Con A) and phytohemagglutinin. The response to PPD was also found to be highly dependent on a population of adherent T cells different from the adherent T cell population involved in the response to Con A. In the case of PPD, the effect was additive, as opposed to the potentiating effect seen for Con A. Further, the adherent T cells involved in the response to PPD were much more sensitive to hypotonic shock than those in the response to Con A. B cells were also found to be important in the response to PPD, although only to a slight extent.

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“…In addi tion, it was shown that this increase in EA-RFC was present in the T-cell population. Imbalances in the T-cell subsets in Hodg kin's disease have also been reported in other studies [25][26][27][28]. Beck et al [29] demonstrated imbalances in the T-cell subsets in patients with non-Hodgkin lym phoma, a finding that could have been present in our NHL patients with high percentages of EA-RFC.…”

Section: Discussionsupporting

confidence: 53%

Fc γ Receptors on Lymphocytes from Normal Donors and Patients with Lymphoproliferative Diseases

Smit¹,

Giessen

Halie³

1983

Acta Haematol

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The antibody-coated human erythrocyte and the antibody-coated ox eryth-rocyte rosette assays (EA_Hu and EA_Ox) were compared to detect Fc γ receptors on human peripheral blood lymphocytes. Two incubation conditions were examined: 1 h at room temperature and overnight at 4°C. In healthy persons, in patients with Hodgkin’s disease and in patients with non-Hodgkin lymphoma (NHL) the mean percentage of EA_Hu-rosette-forming cells (EA_Hu-RFC) increased significantly when the incubation was carried out overnight at 4°C instead of 1 h at room temperature. This increase was caused by Fc γ receptor-bearing T cells. In the case of EA_Ox-RFC only a slight increase was found. The percentage of EA_Hu-RFC and EA_Ox-RFC differed significantly in the healthy group after the overnight incubation and in the NHL group after the 1-hour incubation. When comparing the mean percentage of EA-RFC in the patient groups with that of the healthy persons significant increases were observed: EA_Hu-RFC in patients with Hodgkin’s disease in the overnight incubation and EA_Ox-RFC in patients with Hodgkin’s disease and NHL in both incubation conditions. In patients with chronic lymphocytic leukemia (CLL, B-cell type) the mean percentage of EA_Hu-RFC was very low, however that of EA_Ox-RFC was moderate to high. It is concluded that in the two rosette assays the antigen-antibody complexes may have different avidities to different lymphocyte subpopulations, and that incubation conditions may have an influence on this avidity.

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Altered Proportion of T_μ and T_γ‐Cell Subpopulations in Patients with Hodgkin's Disease

Cited by 38 publications

References 11 publications

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

Role of adherent T cells and of B cells in the immune response to purified protein derivative of tuberculin

Fc γ Receptors on Lymphocytes from Normal Donors and Patients with Lymphoproliferative Diseases

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Altered Proportion of Tμ and Tγ‐Cell Subpopulations in Patients with Hodgkin's Disease

Cited by 38 publications

References 11 publications

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

Distribution of T-lymphocyte subsets in Hodgkin's disease characterized by monoclonal antibodies

Role of adherent T cells and of B cells in the immune response to purified protein derivative of tuberculin

Fc γ Receptors on Lymphocytes from Normal Donors and Patients with Lymphoproliferative Diseases

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Product

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Altered Proportion of T_μ and T_γ‐Cell Subpopulations in Patients with Hodgkin's Disease