Altered plakoglobin expression at mRNA and protein levels correlates with clinical outcome in patients with oropharynx squamous carcinomas

Papagerakis, Silvana; Shabana, A.H.M.; Depondt, J; Pibouin, Laurence; Blin-Wakkach, Claudine; Berdal, Ariane

doi:10.1016/j.humpath.2003.08.018

Cited by 17 publications

(22 citation statements)

References 47 publications

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“…Electron microscopic studies suggested that a reduction in desmosomal adhesion may be associated with invasive behavior in different SCCs [19]. Immunohistochemistry has enabled a more extensive analysis of the expression of desmosomal components in normal and neoplastic tissues [reviewed in 20,21]. However, the sensitivity of immunohistochemistry may depend on various parameters, including tissue conservation and antibody specificity [20,22].…”

Section: Introductionmentioning

confidence: 99%

Altered desmoplakin expression at transcriptional and protein levels provides prognostic information in human oropharyngeal cancer

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Altered desmoplakin expression at transcriptional and protein levels provides prognostic information in human oropharyngeal cancer

et al. 2009

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“…Numerous studies report that altered expression of individual catenins is correlated to prognosis (Shimazui et al, 1996;Mialhe et al, 1997;Morita et al, 1999) with alterations in plakoglobin expression linked to clinical outcome in different tumour types (Pantel et al, 1998;Amitay et al, 2001;Papergerakis et al, 2004). In bladder cancer, loss or reduced plakoglobin expression has been correlated with poor survival (Shimazui et al, 1996;Syrigos et al, 1998).…”

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confidence: 99%

Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential

Rieger-Christ¹,

Ng²,

Hanley³

et al. 2005

Br J Cancer

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The reduction or loss of plakoglobin expression in late-stage bladder cancer has been correlated with poor survival where upregulation of this catenin member by histone deacetylase inhibitors has been shown to accompany tumour suppression in an in vivo model. In this study, we directly addressed the question of the role of plakoglobin in bladder tumorigenesis following restoration, or knockdown of expression in bladder carcinoma cell lines. Restoration of plakoglobin expression resulted in a reduction in migration and suppression of tumorigenic potential in vivo. Immunocytochemistry revealed cytoplasmic and membranous localisation of plakoglobin in transfectants with o1% of cells displaying detectable nuclear localisation of plakoglobin. siRNA knockdown experiments targeting plakoglobin, revealed enhanced migration in all cell lines in the presence and absence of E-cadherin expression. In bladder cell lines expressing low levels of plakoglobin and desmoglein-2, elevated levels of desmoglein-2 were detected following restoration of plakoglobin expression in transfected cell lines. Analysis of wnt signalling revealed no activation event associated with plakoglobin expression in the bladder model. These results show that plakoglobin acts as a tumour suppressor gene in bladder carcinoma cells and the silencing of plakoglobin gene expression in late-stage bladder cancer is a primary event in tumour progression.

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“…10 Reduced catenin expression has been introduced in various malignant neoplasms. [12][13][14][15][16]30 It has been supposed that immunoexpression of the cadherincatenin complex could be used as a marker to predict neoplastic behavior. Indeed, Ueda et al 17 showed that aberrant expression of ␣-and ␥-catenin was more common in poorly differentiated OSCC.…”

Section: Commentmentioning

confidence: 99%

“…11 Reduced expression of ␣-, ␤-, and ␥-catenins has been found to predict an unfavorable prognosis in various malignant neoplasms. [12][13][14] Reduced ␥-catenin expression has also been associated with poor survival in oropharyngeal SCC and OSCC [15][16][17] and in SCC of the floor of the mouth 18 ( Table 1). The aim of this study is to investigate whether reduced expression of catenins predicts poor survival in OSCC.…”

mentioning

confidence: 99%

Reduced γ-Catenin Expression and Poor Survival in Oral Squamous Cell Carcinoma

Närkiö-Mäkelä

Pukkila²,

Lagerstedt³

et al. 2009

Arch Otolaryngol Head Neck Surg

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Altered plakoglobin expression at mRNA and protein levels correlates with clinical outcome in patients with oropharynx squamous carcinomas

Cited by 17 publications

References 47 publications

Altered desmoplakin expression at transcriptional and protein levels provides prognostic information in human oropharyngeal cancer

Altered desmoplakin expression at transcriptional and protein levels provides prognostic information in human oropharyngeal cancer

Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential

Reduced γ-Catenin Expression and Poor Survival in Oral Squamous Cell Carcinoma

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