2005
DOI: 10.1038/sj.bjc.6602651
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Restoration of plakoglobin expression in bladder carcinoma cell lines suppresses cell migration and tumorigenic potential

Abstract: The reduction or loss of plakoglobin expression in late-stage bladder cancer has been correlated with poor survival where upregulation of this catenin member by histone deacetylase inhibitors has been shown to accompany tumour suppression in an in vivo model. In this study, we directly addressed the question of the role of plakoglobin in bladder tumorigenesis following restoration, or knockdown of expression in bladder carcinoma cell lines. Restoration of plakoglobin expression resulted in a reduction in migra… Show more

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Cited by 67 publications
(58 citation statements)
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“…Tumor invasion is represented by reduced cellular adhesion (ICAM1 and DSG2) and cytoskeletal reorganization through increased KRT18 and reduced ARHE expression. DSG2 is a cellular adhesion molecule whose loss reduces adhesion, increases invasion and speeds tumor progression [27]. ICAM1 is also an intercellular adhesion molecule and is frequently epigenetically silenced in UCC (>70%) [28].…”
Section: Discussionmentioning
confidence: 99%
“…Tumor invasion is represented by reduced cellular adhesion (ICAM1 and DSG2) and cytoskeletal reorganization through increased KRT18 and reduced ARHE expression. DSG2 is a cellular adhesion molecule whose loss reduces adhesion, increases invasion and speeds tumor progression [27]. ICAM1 is also an intercellular adhesion molecule and is frequently epigenetically silenced in UCC (>70%) [28].…”
Section: Discussionmentioning
confidence: 99%
“…Plakoglobin has often been associated with tumorsuppressor activity, although the mechanisms behind this activity remain unclear (Simcha et al, 1996;Pantel et al, 1998;Parker et al, 1998;Winn et al, 2002;Reiger-Christ et al, 2005). More recently, downregulation of plakoglobin was also shown to increase the risk of pulmonary metastasis in soft tissue sarcomas (Kanazawa et al, 2008) and was associated with poor differentiation of oral squamous cell carcinoma and with lymph node metastases (Narkio-Makela et al, 2009), further supporting the idea that plakoglobin functions to suppress metastasis in addition to tumor formation.…”
Section: Plakoglobin Interacts With and Regulates Nm23mentioning
confidence: 95%
“…In contrast, plakoglobin has typically been associated with tumor/metastasis-suppressor activity, although the mechanism behind this activity is not understood (Simcha et al, 1996;Pantel et al, 1998;Parker et al, 1998;Winn et al, 2002;Reiger-Christ et al, 2005;Kanazawa et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Tissues-As mentioned above, the armadillo motif-containing protein plakoglobin is known to negatively regulate the motility of epithelial cells (17)(18)(19)(20)(21)(22)(23). Because SLUG in the breast cancer cells regulates the motility of these cells, we hypothesized that SLUG represses plakoglobin gene in these cells to increase their motility.…”
Section: Intracellular Levels Of Slug and Motility Regulatory Proteinmentioning
confidence: 99%
“…Out of several epithelial cell molecules implicated in the direct or indirect regulation of cellular motility, the catenin molecule plakoglobin stands out as a major player in negatively regulating the motility of these cells (17)(18)(19)(20)(21)(22)(23). Plakoglobin (also known as junction plakoglobin (JUP)) is a member of the armadillo family of proteins and a close relative of ␀-catenin (24).…”
mentioning
confidence: 99%