Altered Phenotype and Function of Monocyte-Derived Dendritic Cells in Acute Hepatitis C and Chronic Hepatitis C

Hancharou, Andrei; Titov, Leonid; DuBuske, L.M.

doi:10.1016/j.jaci.2008.12.846

Cited by 3 publications

(3 citation statements)

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“…The MDC function, judged by cytokine production and allostimulatory activity, ranges from normal to impaired in patients who have acute HCV infection [3,[23][24][25]. In addition, patients with acute HCV infection who exhibit low frequency and impaired allostimulatory function of MDCs have a higher chance of developing viral persistence, while an increased numerical prevalence of PDCs in the blood circulation during acute HCV infection could be a predictor of successful viral clearance [24,25].…”

Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

“…In addition, patients with acute HCV infection who exhibit low frequency and impaired allostimulatory function of MDCs have a higher chance of developing viral persistence, while an increased numerical prevalence of PDCs in the blood circulation during acute HCV infection could be a predictor of successful viral clearance [24,25].…”

Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

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Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dolganiuc

Szabó

2011

J Gastroenterol

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Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in ~85% of infected patients and increases their risk for developing liver cirrhosis, hepatocellular carcinoma, and significant extrahepatic manifestations. The mechanisms of HCV persistence remain elusive and are largely related to inefficient clearance of the virus by the host immune system. Dendritic cells (DCs) are the most efficient inducers of immune responses; they are capable of triggering productive immunity and maintaining the state of tolerance to self- and non-self antigens. During the past decade, multiple research groups have focused on DCs, in hopes of unraveling an HCV-specific DC signature or DC-dependent mechanisms of antiviral immunity which would lead to a successful HCV elimination strategy. This review incorporates the latest update in the current status of knowledge on the role of DCs in anti-HCV immunity as it relates to several challenging questions: (a) the phenotype and function of diverse DC subsets in HCV-infected patients; (b) the characteristics of non-human HCV infection models from the DCs' point of view; (c) how can in vitro systems, ranging from HCV protein- or peptide-exposed DC to HCV protein-expressing DCs, and in vivo systems, ranging from HCV protein-expressing transgenic mice to HCV-infected non-human primates, be employed to dissect the role of DCs in triggering/maintaining a robust antiviral response; and (d) the prospect of DC-based strategy for managing and finding a cure for HCV infection.

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Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dolganiuc

Szabó

2011

J Gastroenterol

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“…Содержание mDC в крови пациентов с острым вирусным гепатитом С по данным разных авторов либо не изменено [67], либо снижено [66]. Сообщается также о нарушении дифференцировки и созревания mo-DC, что проявляется повышенной экспрессией CD14 и сниженной экспрессией CD1a, CD86 и CD83 на незрелых mo-DC и уменьшением экспрессии CD86 и HLA-DR на зрелых mo-DC [35]. При этом между количеством/функциями mDC и исходом заболевания выявляется взаимосвязь.…”

Section: презентация вирусных белков и запуск адаптивного ответаunclassified

Dendritic cells in the pathogenesis of viral hepatitis C

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Олейник

Леплина

et al. 2019

Russian Journal of Infection and Immunity

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Резюме. Инфекция, вызванная вирусом гепатита С (HCV), является серьезной проблемой здравоохранения, поскольку в большинстве случаев (до 85%) приобретает хроническое течение и повышает риск развития цирроза печени, гепатоцеллюлярной карциномы и выраженных внепеченочных осложнений. Причины хронизации инфекции во многом связаны с недостаточностью противовирусного иммунного ответа. Эффективная элиминация вируса требует ранней активации врожденного иммунитета, индукции сильного HCV-специфического мультиэпитопного Т-клеточного ответа и формирования продолжительной иммунологической памяти. Дендритные клетки (DC), которые представляют гетерогенную популяцию антигенпрезентирующих клеток, являются продуцентами интерферонов первого типа, способны активировать натуральные киллерные клетки и индуцировать адаптивный иммунный ответ, выполняя, таким образом, важную роль в противовирусной защите. При этом нарушение функций DC при HCV-инфекции рассматривается в качестве одного из механизмов, позволяющих вирусу избежать иммунного надзора. Настоящий обзор включает современные данные, характеризующие роль DC в иммунном ответе при HCV-инфекции и освещает ряд ключевых вопросов, касающихся изменений фенотипа и функций различных субпопуляций DC у пациентов с вирусным гепатитом С, механизмов нарушения функциональной активности DC и перспектив лечения хронического гепатита С на основе использования генерированных ex vivo DC.

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Immunity and Hepatitis C: A Review

Terilli

Cox

2012

Curr HIV/AIDS Rep

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Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma worldwide. Due to shared transmission routes, the prevalence of HCV is especially high among individuals infected with HIV. HIV uninfected individuals spontaneously clear HCV approximately 30% of the time, while the rate of control in HIV infected individuals who subsequently acquire HCV is substantially lower. In addition, complications of HCV are more frequent in those with HIV infection, making liver disease the leading cause of non-AIDS-related death in HIV infected individuals. This review summarizes recent advances in understanding the role of the innate and adaptive immune responses to HCV in those with and without HIV. Further defining the interaction between hepatitis C and the host immune system will potentially reveal insights into HCV pathogenesis and the host’s ability to prevent persistent infection, as well as direct the development of vaccines.

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Altered Phenotype and Function of Monocyte-Derived Dendritic Cells in Acute Hepatitis C and Chronic Hepatitis C

Cited by 3 publications

References 0 publications

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dendritic cells in the pathogenesis of viral hepatitis C

Immunity and Hepatitis C: A Review

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