Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease

Grasselli, Elena; Compalati, Andrea D.; Voci, Adriana; Vecchione, Giulia; Ragazzoni, Milena; Gallo, Gabriella; Borro, Paolo; Sumberaz, Alessandro; Testino, Gianni; Vergani, Laura

doi:10.1016/j.drugalcdep.2014.07.013

Cited by 36 publications

(35 citation statements)

References 48 publications

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“…SOD (a metalloenzyme) converts superoxide anion to hydrogen peroxide, and CAT catalyzes then hydrogen peroxide into molecular oxygen and water. The effects of alcohol exposure on the activity or content of SOD and CAT are rather controversial in the literature, as the activity or content of SOD and CAT might increase, not change, or decrease, depending on the model, diet, amount, and time of alcohol feeding [13,24,28,29]. In this study, the activity of SOD was stimulated in the model with respect to the control group, but CAT decreased.…”

Section: Resultsmentioning

confidence: 65%

“…Antioxidant enzymes and non-enzymatic antioxidants form the antioxidant defense system. The antioxidant enzymes in vivo include superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and hemeoxygenase, and the non-enzymatic antioxidants in vivo contain glutathione (GSH), metallothioneins (MTs), vitamins, ubiquinone, and uric acid [13]. Consumption of alcoholic beverages may lead to the depletion of endogenous antioxidants in the liver.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Zhang

Zhou

Wang

et al. 2016

IJMS

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Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm. Syzygium samarangense and Passiflora edulis normalized various biochemical parameters. Solanum muricatum increased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment with Syzygium samarangense and Passiflora edulis could protect liver from the injury of alcohol, while Solanum muricatum could aggravate the damage.

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Section: Resultsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Zhang

Zhou

Wang

et al. 2016

IJMS

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“…The serum GGT level may be elevated in hepatobiliary disease, with or without elevations in the levels of other liver enzymes. Many previous studies have demonstrated that both low and moderate levels of chronic alcohol consumption are associated with an increased BMI (Conigrave et al2003a) and that they cause varying degrees of liver damage, with elevated ALT (Conigrave et al2003b), AST (Conigrave et al2003c), ALP (Das and Vasudevan 2005) and GGT levels (Conigrave et al2003d;Hietala et al 2005;Das and Vasudevan 2005;Grasselli et al 2014) and even moderate/severe hepatic steatosis (Conigrave et al2003e). However, another study has reported conflicting results, showing that heavy drinkers have a significantly lower body weight, percent body fat, and BMI compared with non-heavy drinkers (Das and Vasudevan 2005).…”

Section: Discussionmentioning

confidence: 99%

Association between circulating inflammatory molecules and alcoholic liver disease in men

Jia³

et al. 2016

Cell Stress and Chaperones

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The association between alcoholic liver disease (ALD) and the inflammatory response remains controversial. The aim of this study was to explore this association between ALD and inflammation. We enrolled 214 male participants, who were divided into three age-matched groups: ALD (n = 135), chronic alcohol ingestion without ALD (non-ALD; n = 42), and control (n = 37). The BMI was significantly higher in the ALD group than in the non-ALD and control groups (all P = 0.000). Further, the constituent ratio of the liver inflammatory level was significantly higher in the ALD group than in the non-ALD and control groups (P = 0.002 and P = 0.000, respectively). In addition, the median serum ALT, AST, and GGT levels were significantly higher in the ALD group than in the control group (P = 0.023, P = 0.008, and P = 0.000, respectively); these levels were also significantly higher in the ALD group than in the non-ALD group (P = 0.013, P = 0.010, and P = 0.000, respectively). The median serum CRP level was significantly higher in the ALD group than in the non-ALD and control groups (P = 0.006 and P = 0.000, respectively). Further, the median serum TNF-α level was significantly lower in the ALD group than in the non-ALD and control groups (P = 0.004 and P = 0.000, respectively). The median serum sOX40L and HSP70 levels were significantly lower in the ALD group than in the control group (P = 0.008 and P = 0.018, respectively). In addition, the ALT, AST, and GGT levels were positively correlated with the CRP level (r = 0.211, P = 0.002; r = 0.220, P = 0.001 and r = 0.295, P = 0.000, respectively), and the GGT level was negatively correlated with the TNF-α (r = −0.225, P = 0.001), sOX40L (r = −0.165, P = 0.016), and HSP70 levels (r = −0.178, P = 0.009). Further, the Cr level was negatively correlated with the IL-10 level (r = −0.166, P = 0.015). Logistic regression analysis verified that the BMI (OR = 1.637, 95%CI: 1.374-1.951, P = 0.000) and GGT level were significantly higher (OR = 1.039, 95%CI: 1.020-1.059, P = 0.000) and that the TNF-α (OR = 0.998, 95%CI: 0.996-1.000, P = 0.030) and HSP70 levels were significantly lower (OR = 1.017, 95%CI: 1.003-1.031, P = 0.029) in the ALD group than in the non-ALD group. Further, the moderate-to-severe ALD patients had a significantly higher serum CRP level (Or = 1.349, 95%CI: 1.066-1.702, P = 0.013) and significantly lower HSP60 (OR = 0.965, 95%CI: 0.938-0.993, P = 0.014) and HSP70 levels (OR = 0.978, 95%CI: 0.962-0.995, P = 0.010) than the mild ALD patients. These results suggest that ALD patients may present with obesity, liver damage, and an imbalanced inflammatory immune response, mainly manifesting as decreased levels of immune inflammatory cytokines. In addition, they suggest that certain liver and kidney function parameters and ALD severity are either positively or negatively correlated with certain inflammatory cytokines. Hence, ALD patients may be at increased risks of obesity-and inflammation-related diseases. Accordingly, to control the inflammatory response, preventativ...

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“…[6]. Одна-ко, в отличие от полученных нами сведений, в данной работе было обнаружено, что у зло-употребляющих алкоголем лиц параллельно повышена относительная концентрация α 1 -и β 2 -глобулинов, что исследователи трактуют как сдвиги воспалительного генеза.…”

Section: теоретическая и клиническая медицинаunclassified

Clinical and biochemical aspects of coagulation control in patients with atrial fibrillation and excessive alcohol consumption

et al. 2015

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Aim. Reveal the influence of excessive alcohol consumption on blood coagulation system, levels of blood proteins in patients with atrial fibrillation treated with warfarin. Methods. The study included 80 patients with a diagnosis of atrial fibrillation, treated with vitamin K antagonists. The study group included 34 patients with excessive alcohol consumption (according to the questionnaire), the comparison group - 46 patients with no excessive alcohol consumption. Transferrin, hemopexin, aspartate transaminase, alanine transaminase, gamma-glutamyl transferase, carbohydrate-deficient transferrin levels were measured in venous blood serum, serum protein electrophoresis was performed. Parameters of plasma hemostasis tests and D-dimer level were also analyzed. Results. Gamma-glutamyl transferase activity in patients of study group was 1.5 times higher compared to the comparison group (p=0.021). There was no statically significant differences in aspartate transaminase and alanine transaminase activity, but their levels were increased in alcohol abusers with gamma-glutamyl transferase above normal values (55 U/l). None of the patients had increased level of carbohydrate-deficient transferrin. Absolute and relative serum β1-globulin concentrations were significantly reduced in study group patients, while hemopexin and transferrin levels were at the same level as in the control group. No differences of coagulation parameters were between the groups. In the study group, in patients with β1-globulin levels below the median values, international normalized ratio was significantly closer to the target values, but the same patients had higher D-dimer levels, which apparently indicates low effect of anticoagulants. Conclusion. The effect of anticoagulant was low in patients with excessive alcohol consumption and atrial fibrillation, as evidenced by elevated D-dimer levels at international normalized ratio close to the target values. Patients with atrial fibrillation and excessive alcohol consumption with elevated D-dimer levels had serum β1-globulin levels reduced compared to median values.

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Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease

Cited by 36 publications

References 48 publications

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Association between circulating inflammatory molecules and alcoholic liver disease in men

Clinical and biochemical aspects of coagulation control in patients with atrial fibrillation and excessive alcohol consumption

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