Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass

Zoon, H.F.A.; Bruijn, S.E.M. de; Jager, Gerry; Smeets, Paul A.M.; Graaf, C. de; Janssen, Ignace M. C.; Schijns, Wendy; Deden, Laura N.; Boesveldt, Sanne

doi:10.1016/j.biopsycho.2018.06.005

Cited by 29 publications

(26 citation statements)

References 58 publications

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“…PHIPP is also implicated in food craving, the physiologic state of hunger, when motivationally relevant food objects are shown [14], and when tasting a liquid meal. Several neuroimaging studies showed increased PHIPP activation to high-energy visual food cues and decreased PHIPP activation after weight loss surgery [31]. Our previous study also showed that WM densities were lower in PHIPP in obese relative to healthy weight individuals.…”

Section: Alterations In Regions Associated With Memorysupporting

confidence: 49%

Laparoscopic sleeve gastrectomy induces sustained changes in gray and white matter brain volumes and resting functional connectivity in obese patients

Wang

et al. 2020

Surgery for Obesity and Related Diseases

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Background: Obesity is associated with decreased brain gray-(GM) and white-matter (WM) volumes in regions. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery associated with neuroplastic changes in patients with obesity at 1 month postLSG. Objective: To investigate whether LSG can induce sustained neuroplastic recovery of brain structural abnormalities, and whether structural changes are accompanied by functional alterations. Setting: University hospital, longitudinal study. Methods: Structural magnetic resonance imaging and voxel-based morphometry analysis were employed to assess GM/WM volumes in 30 obese participants at preLSG and 1 and 3 months postLSG. One-way analysis of variance modeled time effects on GM/WM volumes, and then alterations in resting-state functional connectivity (RSFC) were assessed.

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Section: Alterations In Regions Associated With Memorysupporting

confidence: 49%

Laparoscopic sleeve gastrectomy induces sustained changes in gray and white matter brain volumes and resting functional connectivity in obese patients

Wang

et al. 2020

Surgery for Obesity and Related Diseases

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“…Similarly to the effects of GLP-1R agonism described above, RYGB surgery reduces insula and PFC BOLD signals in response to visual and auditory food cues in fasted obese women [45]. RYGB surgery also increases precuneus BOLD response to low fat/sugar food cues while decreasing response to high fat/sugar food cues [46]. Finally, weight loss and decreased appetite for sweet and fat foods after RYGB surgery coincides with reduced resting-state functional connectivity between the insula and the anterior cingulate as well as improved sensitivity of the default mode network to GLP-1R blockade [47].…”

Section: Human Studiesmentioning

confidence: 83%

Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward

Décarie-Spain

Kanoski

2021

Nutrients

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Eating behaviors are influenced by the reinforcing properties of foods that can favor decisions driven by reward incentives over metabolic needs. These food reward-motivated behaviors are modulated by gut-derived peptides such as ghrelin and glucagon-like peptide-1 (GLP-1) that are well-established to promote or reduce energy intake, respectively. In this review we highlight the antagonizing actions of ghrelin and GLP-1 on various behavioral constructs related to food reward/reinforcement, including reactivity to food cues, conditioned meal anticipation, effort-based food-motivated behaviors, and flavor-nutrient preference and aversion learning. We integrate physiological and behavioral neuroscience studies conducted in both rodents and human to illustrate translational findings of interest for the treatment of obesity or metabolic impairments. Collectively, the literature discussed herein highlights a model where ghrelin and GLP-1 regulate food reward-motivated behaviors via both competing and independent neurobiological and behavioral mechanisms.

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“…Using fMRI, obese subjects present attenuated hypothalamic signals in response to glucose [8,10], cold [11], overfeeding [24], and food image cues [25]. Available data also suggest that such obesity-associated abnormalities in hypothalamic responses can be ameliorated following body mass reduction obtained as a result of a RYGB [10,26].…”

Section: Discussionmentioning

confidence: 99%

Radiologic evidence that hypothalamic gliosis is improved after bariatric surgery in obese women with type 2 diabetes

et al. 2019

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Background/Objectives-Hypothalamic neurons play a major role in the control of body mass. Obese subjects present radiologic signs of gliosis in the hypothalamus, which may reflect the damage or loss of neurons involved in whole-body energy homeostasis. It is currently unknown if hypothalamic gliosis (1) differs between obese nondiabetic (ND) and obese diabetic subjects (T2D) or (2) is modified by extensive body mass reduction via Roux-n-Y gastric bypass (RYGB). Subjects/Methods-Fifty-five subjects (all female) including lean controls (CT; n = 13), ND (n = 28), and T2D (n = 14) completed at least one study visit. Subjects underwent anthropometrics and a multi-echo MRI sequence to measure mean bilateral T2 relaxation time in the mediobasal hypothalamus (MBH) and two reference regions (amygdala and putamen). The obese groups underwent RYGB and were re-evaluated 9 months later. Analyses were by linear mixed models. Results-Analyses of T2 relaxation time at baseline showed a group by region interaction only in the MBH (P < 0.0001). T2D had longer T2 relaxation times compared to either CT or ND groups. To examine the effects of RYGB on hypothalamic gliosis a three-way (group by region by time) mixed effects model adjusted for age was executed. Group by region (P < 0.0001) and region Licio A. Velloso,

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Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass

Cited by 29 publications

References 58 publications

Laparoscopic sleeve gastrectomy induces sustained changes in gray and white matter brain volumes and resting functional connectivity in obese patients

Laparoscopic sleeve gastrectomy induces sustained changes in gray and white matter brain volumes and resting functional connectivity in obese patients

Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward

Radiologic evidence that hypothalamic gliosis is improved after bariatric surgery in obese women with type 2 diabetes

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