Altered N-methyl-d-aspartate receptor function in reelin heterozygous mice: Male–female differences and comparison with dopaminergic activity

Buuse, Maarten van den; Halley, Paul; Hill, Rachel Anne; Labots, Maaike; Martin, Sally

doi:10.1016/j.pnpbp.2012.02.005

Cited by 35 publications

(34 citation statements)

References 46 publications

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“…Hence the potent inhibition of LTP by Aβ 1-42 in an ApoE ε4 background (Trommer et al, 2005) can be explained by Reelin being outcompeted by ApoE ε4 to activate its downstream signaling and antagonizes Aβ. This is in line with the impaired LTP and cognitive performance seen in Reelin heterozygous knock-out mice (Krueger et al, 2006, Qiu et al, 2006, likely representing a consequence of altered NMDA receptor function in these mice (van den Buuse et al, 2012). In agreement, both Reelin heterozygous knock-out (Ohkubo et al, 2003) and ApoE ε4 knock-in mice (Kobayashi et al, 2003, Harris et al, 2004 show increased levels of Tau phosphorylation.…”

Section: Dysfunctional Reelin Signaling and Its Role In Ad Etiologysupporting

confidence: 79%

Decisive role of Reelin signaling during early stages of Alzheimer’s disease

et al. 2013

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Alzheimer's disease (AD) is one of the largest unmet medical concerns of our society. Around 25 million patients worldwide together with their families are still waiting for an effective treatment. We have recently initiated a re-evaluation of our knowledge of the molecular and cellular mechanisms underlying sporadic AD. Based on the existing literature, we have proposed a mechanistic explanation of how the late-onset form of the disease may evolve on the cellular level. Here, we expand this hypothesis by addressing the pathophysiological changes underlying the early and almost invariant appearance of the neurofibrillary tangles, the only reliable correlate of the cognitive status, in distinct brain areas and their consistent "spread" along interconnected neurons as the disease advances. In this review we present and discuss novel evidence that the extracellular signaling protein Reelin, expressed along the olfactory and limbic pathways in the adult brain, might hold a key to understand the earliest steps of the disease, highlighting the olfactory pathway as the brain's Achilles heel involved in the initiation of the pathophysiological characteristic of late-onset AD. AbstractAlzheimer`s disease (AD) is one of the largest unmet medical needs of our society. Around 25 million patients worldwide together with their families are still waiting for an effective treatment. We have recently initiated a re-evaluation of our knowledge of the molecular and cellular mechanisms underlying sporadic AD. Based on the existing literature, we have proposed a mechanistic explanation of how the late-onset form of the disease may evolve on the cellular level. Here, we expand this hypothesis by addressing the pathophysiological changes underlying the early and almost invariant appearance of the neurofibrillary tangles (NFTs), the only reliable correlate of the cognitive status, in distinct brain areas and their consistent "spread" along interconnected neurons as the disease advances. In this review we present and discuss novel evidence that the extracellular signaling protein Reelin, expressed along the olfactory and limbic pathways in the adult brain, might hold a key to understand the earliest steps of the disease, highlighting the olfactory pathway as the brain's Achilles heel involved in the initiation of the pathophysiology characteristic of late-onset AD.3

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Section: Dysfunctional Reelin Signaling and Its Role In Ad Etiologysupporting

confidence: 79%

Decisive role of Reelin signaling during early stages of Alzheimer’s disease

et al. 2013

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“…One previous study showed that late adolescent female CFW mice had a greater response than males to 5 mg/kg AMPH (Goodrich and Lange 1986). Two studies in mice generated on C57BL/6N or C57BL/6J backgrounds showed increased responses in adult female mice compared to males after 3.5 and 5 mg/kg AMPH (Siuciak et al 2007; van den Buuse et al 2012). In contrast, one study in adult CD1 mice did not report an effect of sex after 2 or 10 mg/kg AMPH (Adriani and Laviola 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Studies of behavioral and neurochemical differences in genetically altered mice have shown that such effects can be sex-specific, so sexual dimorphisms must be carefully considered (Kuppers et al 2008; Siuciak et al 2007; van den Buuse et al 2012). Previous studies have reported psychostimulant-induced stereotyped behavior in mice using behavioral scales developed in rats, but the topography of psychostimulant-induced behavior in mice has not been carefully characterized.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice

2012

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Rationale Women are more sensitive than men to psychostimulants and progress from initial use to drug addiction more quickly. The mouse has been an under-utilized model to study sex differences in psychostimulant action. Mice could serve as an ideal genetically-tractable model for mechanistic studies into sex and hormone effects on psychostimulant behavior. Objectives To characterize psychostimulant effects in male and female mice with a combination of automated data collection and behavioral observation. Methods Male and female C57BL/6 mice (Charles River) were given a single dose or sequential ascending binge doses of d-amphetamine (AMPH) or cocaine (COC). Behavior was assessed in open field chambers using both automated photobeam interruptions and behavioral observations. Brain psychostimulant concentrations were determined at the time of maximum behavioral stimulation. Results Psychostimulants induced behavioral activation in mice including both increased locomotion as detected with an automated system and a sequence of behaviors progressing from stereotyped sniffing at low doses to patterned locomotion and rearing at high doses. Females exhibited more patterned locomotion and a shift towards higher behavior scores after either psychostimulant despite having lower AMPH and equivalent COC brain levels as males. Conclusions Female C57BL/6 mice exhibit enhanced psychostimulant-induced behavior compared to males, similar to reports in rats. The combination of automated behavioral measures and behavioral observation was essential for verifying the existence of these differences. These results indicate the importance of testing both sexes when characterizing genetically manipulated mice to control for potential sex-specific effects.

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“…However, this manipulation demonstrated no change in prepulse inhibition and a reduction in the effect of the hallucinogen 5-MeO-DMT, making it less fitting as a model psychosis [197]. …”

Section: Manipulations To Neurotransmitter Systemsmentioning

confidence: 99%

Animal Models of Psychosis: Current State and Future Directions

Forrest

Coto

Siegel

2014

Curr Behav Neurosci Rep

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Psychosis is an abnormal mental state characterized by disorganization, delusions and hallucinations. Animal models have become an increasingly important research tool in the effort to understand both the underlying pathophysiology and treatment of psychosis. There are multiple animal models for psychosis, with each formed by the coupling of a manipulation and a measurement. In this manuscript we do not address the diseases of which psychosis is a prominent comorbidity. Instead, we summarize the current state of affairs and future directions for animal models of psychosis. To accomplish this, our manuscript will first discuss relevant behavioral and electrophysiological measurements. We then provide an overview of the different manipulations that are combined with these measurements to produce animal models. The strengths and limitations of each model will be addressed in order to evaluate its cross-species comparability.

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Altered N-methyl-d-aspartate receptor function in reelin heterozygous mice: Male–female differences and comparison with dopaminergic activity

Cited by 35 publications

References 46 publications

Decisive role of Reelin signaling during early stages of Alzheimer’s disease

Decisive role of Reelin signaling during early stages of Alzheimer’s disease

Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice

Animal Models of Psychosis: Current State and Future Directions

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