Altered motivation of effortful decision‐making for self and others in subthreshold depression

Rong, Bi; Dong, Wanxin; Zheng, Zixin; Li, Sijin; Zhang, Dandan

doi:10.1002/da.23267

Cited by 9 publications

(2 citation statements)

References 79 publications

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“…Nevertheless, women were much more often emphasised the problem of “lack of motivation”. Due to the lack of evidence of a relationship between sex and other obstacles declared by patients, the role of undiagnosed depression, which more often affects women, 39 40 is associated with excessive body weight, 41 and for which lack of motivation is a common feature, 42 cannot be underestimated.…”

Section: Discussionmentioning

confidence: 99%

Level and limitations of physical activity in patients with excess body weight or diabetes

Sutkowska,

Biernat,

Mazurek

et al. 2024

BMJ Open Sport Exerc Med

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Physical activity (PA) is recommended to prevent or treat many diseases, but various factors may limit it. We analyse the level of PA and the barriers to undertaking it. Patients aged 18–64 with diabetes or at least overweight completed the following questionnaires: International Physical Activity Questionnaire (IPAQ) and Accompanying Survey (AS). For statistical analysis, non-parametric Mann-Whitney U, χ2—Pearson, correspondence analysis and meta-analysis (OR with ±95% CI) were used, and α=0.05 was assumed. Of 191 sets of questionnaires were analysed (67% from women). The median (MD) age for the group was 50.5 years, MD for metabolic equivalents (METs): 2079 (MET-min/week); 16.23% of subjects scored insufficient, 46.07% sufficient and 37.7% high PA according to the IPAQ scale. A relationship between the IPAQ and PA level results from the AS was confirmed (χ2; p=0.00047). The most common reasons indicated for not taking up PA were lack of time due to professional work (49%) and additional duties (32%) as well as fatigue from daily duties (44%). Participants <45 years were more likely to indicate additional duties (p=0.013), participants >45 years illnesses (p=0.04) and people with BMI (body mass index) ≥30 kg/m2, ‘fatigue from daily duties’ (p=0.019) as an obstacle to undertaking PA. ‘Lack of suitable conditions to undertake PA’ was indicated more often by patients with primary education (p<0.01), diabetes (p=0.037), after myocardial infarction (p=0.039) and those under psychiatric treatment (p=0.039). Women more often declared a lack of motivation (p=0.018). Residents of big cities and those with BMI ≥30 were more likely to assess their PA as ‘insufficient’ (p=0.0260 and p=0.0081, respectively). The overwhelming number of respondents who were in the age of professional activity had a sufficient level of PA. The most common barriers to undertaking PA were lack of time and fatigue, related to both work and non-work activities, but specific barriers were also found for women and patients with various diseases.

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Section: Discussionmentioning

confidence: 99%

Level and limitations of physical activity in patients with excess body weight or diabetes

Sutkowska,

Biernat,

Mazurek

et al. 2024

BMJ Open Sport Exerc Med

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“…In common with impaired motivational effort decision‐making and self‐relevant processing in depressive individuals (Hobbs et al, 2021; Horne et al, 2021), StD displayed blunted activity in the bilateral anterior insula and right putamen‐left dorsolateral prefrontal cortex functional connectivity when choosing to exert effort for themselves, while greater activation in the bilateral anterior insula when choosing to exert effort for others (Bi et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

Li,

Kuang,

Liu

et al. 2024

Human Brain Mapping

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Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta‐analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate‐based meta‐analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future.

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Altered motivation of effortful decision‐making for self and others in subthreshold depression

Rong

Dong

Zheng

et al. 2022

Depression and Anxiety

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Background: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards.However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear.Methods: We conducted a functional magnetic resonance imaging study and employed an adapted Effort-Expenditure for Rewards Task in subthreshold depressive (SD) participants (n = 33) and healthy controls (HC) (n = 32). This required participants to choose between a fixed low-effort/low-reward and a variable higheffort/high-reward option, and then immediately exert effort to obtain corresponding rewards for themselves or for unfamiliar people.Results: Compared with the HC group, the SD group showed blunted activity in the left dorsal anterior cingulate cortex/dorsomedial prefrontal cortex, bilateral anterior insula (AI), and right putamen-left dorsolateral prefrontal cortex functional connectivity when choosing to exert effort for themselves. Additionally, the SD group exhibited increased willingness and greater activation in the bilateral AI when choosing to exert effort for others. Furthermore, these brain activations and functional connectivity were positively related to self-reported motivation.Conclusions: These findings show altered motivation during effort-based decisionmaking in individuals with the mild depressive state, particularly with higher motivation for others. Thus, this suggests that motivational behaviors and prefrontal-striatal circuitry are altered in individuals with SD, which can be utilized to discover treatment targets and develop strategies to address mental illness caused by motivation disorders.

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Altered motivation of effortful decision‐making for self and others in subthreshold depression

Cited by 9 publications

References 79 publications

Level and limitations of physical activity in patients with excess body weight or diabetes

Level and limitations of physical activity in patients with excess body weight or diabetes

Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

Altered motivation of effortful decision‐making for self and others in subthreshold depression

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