Altered Modulation of Prefrontal and Subcortical Brain Activity in Newly Diagnosed Schizophrenia and Schizophreniform Disorder

Assessment of cognitive development in adolescents by means of neuropsychological tasks

“…Examination of regional cerebral blood flow by single photon emission computed tomography and PET shows activation of the frontal cortex region during performance of theWCST Daniel et al, 1991;Marenco, Coppola, Daniel, Zigun, & Weinberger, 1993;Rezai et al, 1993;Rubin et al, 1991) and the Stroop test (Bench et al, 1993). These studies provide independent confirmation that the tasks selected for assessment of frontal lobe function in this study do depend on the function of the frontal lobes.…”

Abnormalities in the Distributed Network of Sustained Attention Predict Neuroleptic Treatment Response in Schizophrenia

“…In summary, our findings that treatment-resistant schizophrenics demonstrate frontal hypometabolism in the presence of striatal hyperactivity is very similar to the data reported by two other groups working with schizophrenic patients who had never received neuroleptics before (Biver et al 1995;Rubin et al 1991). Rubin et al (1991) interpreted their results, obtained while patients performed the Wisconsin Card Sort, as suggestive of impaired striatal suppression on the left side.…”

“…Rubin et al (1991) interpreted their results, obtained while patients performed the Wisconsin Card Sort, as suggestive of impaired striatal suppression on the left side. The requirements of CPT are also associated with suppression of "quieting" of a number of brain regions including the basal ganglia and mid-cingulate.…”

Functional Magnetic Resonance Imaging Brain Mapping in Psychiatry: Methodological Issues Illustrated in a Study of Working Memory in Schizophrenia

“…It is also important to note that the never-medicated patients in this study were similar to patients on medication, consistent with earlier studies. (Andreasen et al 1992;Rubin et al 1991;Catafau et al 1994). Clearly, these issues warrant further study in larger patient samples.…”