Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease

Jiang, Hong; Wei, Yantao; Shi, Yingying; Wright, Clinton B.; Sun, Xiaoyan; Gregori, Giovanni; Zheng, Fang; Vanner, Elizabeth A.; Lam, Byron L.; Rundek, Tatjana; Wang, Jianhua

doi:10.1097/wno.0000000000000580

Cited by 155 publications

(233 citation statements)

References 34 publications

(55 reference statements)

Supporting

Mentioning

207

Contrasting

Unclassified

Order By: Relevance

“…In those with mild cognitive impairment, only the density of the superior deep vascular plexus is decreased. This suggests a compromise, possibly at the level of the ganglion cell layers, which supports the argument that loss of ganglion cells, because of compromised vascular networks, may contribute to a thinner macula. OCT‐angiography is superior to fluorescein angiography in that it is non‐invasive, with no side effects, and provides detailed information about the superficial, deep and the middle capillary plexus …”

Section: Alzheimer's Diseasesupporting

confidence: 73%

Optical coherence tomography in the investigation of systemic neurologic disease

Srinivasan

Efron

2019

Clinical and Experimental Optometry

View full text Add to dashboard Cite

Optical coherence tomography (OCT) is a well-established technique for the clinical examination, diagnosis, severity staging and monitoring of ophthalmic disorders. The application of this technology has more recently been extended beyond ophthalmic disease, whereby it has been demonstrated that OCT can serve as an ophthalmic marker for a range of systemic neurodegenerative disorders, such as Parkinson's disease, multiple sclerosis, Alzheimer's disease and diabetic peripheral neuropathy. This review will focus on the clinical utility of OCT-derived retinal measures for the investigation of these conditions.

show abstract

Section: Alzheimer's Diseasesupporting

confidence: 73%

Optical coherence tomography in the investigation of systemic neurologic disease

Srinivasan

Efron

2019

Clinical and Experimental Optometry

View full text Add to dashboard Cite

show abstract

“…Three of these focused on CI, and even with differences in ROI, imaging device, vessel segmentation software, FD calculation method and software, all three confirmed a significant decrease of FD measures in CI (including dementia) (Cabrera DeBuc et al, 2018), mild CI (Jiang et al, 2018) and AD (Csincsik et al, 2018). After a follow-up period of 2 years, Csincsik et al reported that the significant difference in FD between AD and controls at baseline had become a trend (Csincsik et al, 2018), whereas Jiang et al described a trend of vascular density loss from controls over MCI to AD cases (Jiang et al, 2018). A significant association between fractal dimension and Montreal Cognitive Assessment (MoCA) could not be confirmed (Cabrera DeBuc et al, 2018).…”

Section: Outcomes Of Fractal Analysis In Studies On Neurodegenerativementioning

confidence: 89%

Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker

et al. 2020

View full text Add to dashboard Cite

Introduction: Ocular manifestations in several neurological pathologies accentuate the strong relationship between the eye and the brain. Retinal alterations in particular can serve as surrogates for cerebral changes. Offering a "window to the brain," the transparent eye enables non-invasive imaging of these changes in retinal structure and vasculature. Fractal dimension (FD) reflects the overall complexity of the retinal vasculature. Changes in FD could reflect subtle changes in the cerebral vasculature that correspond to preclinical stages of neurodegenerative diseases. In this review, the potential of this retinal vessel metric to serve as a biomarker in neurodegeneration and stroke will be explored.Methods: A literature search was conducted, following the PRISMA Statement 2009 criteria, in four large bibliographic databases (Pubmed, Embase, Web Of Science and Cochrane Library) up to 12 October 2019. Articles have been included based upon their relevance. Wherever possible, level of evidence (LOE) has been assessed by means of the Oxford Centre for Evidence-based Medicine Level of Evidence classification.Results: Twenty-one studies were included for qualitative synthesis. We performed a narrative synthesis and produced summary tables of findings of included papers because methodological heterogeneity precluded a meta-analysis. A significant association was found between decreased FD and neurodegenerative disease, mainly addressing cognitive impairment (CI) and dementia. In acute, subacute as well as chronic settings, decreased FD seems to be associated with stroke. Differences in FD between subtypes of ischemic stroke remain unclear. Conclusions:This review provides a summary of the scientific literature regarding the association between retinal FD and neurodegenerative disease and stroke. Central pathology is associated with a decreased FD, as a measure of microvascular network complexity. As retinal FD reflects the global integrity of the cerebral microvasculature, it is an attractive parameter to explore. Despite obvious concerns, mainly due to a lack of methodological standardization, retinal FD Lemmens et al.Retinal Fractals: Neurodegeneration and Stroke remains a promising non-invasive and low-cost diagnostic biomarker for neurodegenerative and cerebrovascular disease. Before FD can be implemented in clinic as a diagnostic biomarker, the research community should strive for uniformization and standardization.

show abstract

“…Jiang et al have reported differences using fractal analysis on OCTA superficial and deep capillary plexus between patients with AD and control subjects. 25…”

Section: Practical Retinamentioning

confidence: 99%

Is OCT Angiography Useful in Neurodegenerative Diseases?

Grewal¹,

Fine²,

Fekrat³

2019

Ophthalmic Surg Lasers Imaging Retina

View full text Add to dashboard Cite

Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease

Abstract: Patients with AD had less density of retinal microvascular networks than controls. Our findings suggest the presence of retinal microvascular dysfunction in AD.

Cited by 155 publications

References 34 publications

Optical coherence tomography in the investigation of systemic neurologic disease

Optical coherence tomography in the investigation of systemic neurologic disease

Systematic Review on Fractal Dimension of the Retinal Vasculature in Neurodegeneration and Stroke: Assessment of a Potential Biomarker

Is OCT Angiography Useful in Neurodegenerative Diseases?

Contact Info

Product

Resources

About