Altered immune response during cadmium administration in mice

Malavé, Inés; Ruffino, Donatella T. de

doi:10.1016/0041-008x(84)90268-0

Cited by 39 publications

(12 citation statements)

References 16 publications

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“…Airborne pollutants enter the respiratory system via the extensive surface of the lungs (12). The toxic effects of the metals induded in this research are of serious concern (13)(14)(15)(16)(17). The toxicity of lead on the central nervous system and on organs such as the (23,24).…”

Section: Discussionmentioning

confidence: 99%

Metals in lung tissue from autopsy cases in Mexico City residents: comparison of cases from the 1950s and the 1980s.

Fortoul¹,

Osorio²,

Tovar³

et al. 1996

Environ Health Perspect

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In autopsies performed on residents of Mexico City during the 1950s and 1980s (45 males and 24 females and 42 males and 42 females, respectively), concentrations of cadmium, copper, cobalt, nickel, and lead in the lungs were studied by atomic absorption spectrometry. Sharp increases were noted in samples taken in the 1980s compared to those from the 1950s. In samples from both time periods, the concentrations were influenced by gender. Smoking was not associated with higher levels of the metals. Only lead seemed to have a relation with age. The enormous differences by gender in the 1950s could be due to different patterns of exposure. The differences among samples from both periods appear to be associated with the increase of air pollutants in the metropolitan areas of Mexico City during the years under study. These results reinforce the importance of studying lung tissue to monitor air pollution by metals.

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Section: Discussionmentioning

confidence: 99%

Metals in lung tissue from autopsy cases in Mexico City residents: comparison of cases from the 1950s and the 1980s.

Fortoul¹,

Osorio²,

Tovar³

et al. 1996

Environ Health Perspect

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“…These bacteria are ubiquitous in fresh water, present on the skin and in the digestive tracts of healthy organisms, and apparently, successfully attack immunosuppressed individuals (11). Laboratory studies indicate that immunosuppression can be induced by injection of corticosterone (one of the hormones associated with responses to stress) or exposure to heavy metals, certain pesticides or industrial chemicals, and cold (12)(13)(14) (2) or mortality of both adults and larvae (10), a few observations raise the possibility that larvae or particular size classes of newly metamorphosed individuals might be more susceptible to disease than adults. For instance, infection of Aeromonas hydrophila was more prevalent in larval than adult leopard frogs (Rana pipiens) in a population in Minnesota (15).…”

Section: Introductionmentioning

confidence: 99%

Possible Interrelations among Environmental Toxicants, Amphibian Development, and Decline of Amphibian Populations

Carey¹,

Bryant²

1995

Environmental Health Perspectives

195

120

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Many amphibian populations are declining in a number of geographical locations throughout the world. In most cases, the cause or causes are unknown, but are assumed to result from man-made alterations in the environment. We review existing evidence concerning how environmental xenobiotics could contribute to declines of amphibian populations by impacting growth and development of the young. This paper examines the potential roles of toxicants in: a) affecting the susceptibility of young to disease; b) retarding growth and development of amphibian young; c) affecting the ability of larvae to avoid predation; d) affecting the development of physiological, morphological, or behavioral processes in a manner that subsequently impairs the ability of the young for future reproduction; and e) directly causing mortality of young. These issues are not well studied, and more studies are needed before the roles of environmental xenobiotics in amphibian declines are fully understood. Environ Health Perspect 103(Suppl 4): 13-17 (1995)

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“…However, the same dose administered ip (127) or single doses of 1.48, 2.96, 5.91, or 1.81 mg/kg bw administered im had no effect (128). Similarly, the studies by Malave and De Ruffino (129) indicated that a dose of 50 ppm of CdCl2 administered orally to CD-I mice for 3 to 9 weeks resulted in an increase of the PFC numbers. Doses of 10, 50, or 250 ppm administered to B6C3F, mice for 90 days had no detectable effect on the PFC numbers (122).…”

Section: Experimenal Studies Ofcd In Vivomentioning

confidence: 89%

Immunotoxicity of heavy metals in relation to Great Lakes.

Bernier

Brousseau

Krzystyniak

et al. 1995

Environ Health Perspect

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Heavy metals including mercury, lead, and cadmium are present throughout the ecosystem and are detectable in small amounts in the Great Lakes water and fish. The main route of exposure of humans to these metals is via the ingestion of contaminated food, especially fish. Extensive experimental investigations indicated that heavy metals alter a number of parameters of the host's immune system and lead to increased susceptibility to infections, autoimmune diseases, and allergic manifestations. The existing limited epidemiologic data and data derived from in vitro systems in which human peripheral blood leukocytes were used suggested that the human immune system may also be at increased risk following exposure to these metals. The magnitude of the risk that the presence of such metals in the Great Lakes may pose to the human immune system, and consequently to their health, is not known. In this review, the available data with respect to potential adverse effects of heavy metals on the immune system of humans and experimental animals are discussed, and additional data requirements are suggested. Environ Health Perspect 103(Suppl 9): 23-34 (1995)

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Altered immune response during cadmium administration in mice

Cited by 39 publications

References 16 publications

Metals in lung tissue from autopsy cases in Mexico City residents: comparison of cases from the 1950s and the 1980s.

Metals in lung tissue from autopsy cases in Mexico City residents: comparison of cases from the 1950s and the 1980s.

Possible Interrelations among Environmental Toxicants, Amphibian Development, and Decline of Amphibian Populations

Immunotoxicity of heavy metals in relation to Great Lakes.

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